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产品概述
| 名称 | MDA-MB-231 (人乳腺癌细胞) (L15) (STR鉴定正确) |
| 别称 | MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA231; MB231; MD Anderson-Metastatic Breast-231 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 生长培养基 | Leibovitz's L-15＋10% FBS＋1% P/S |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，100% 温度：37℃ |
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2~3次/周 |
| 注意事项 | 1、该细胞推荐使用Leibovitz's L-15培养基进行培养，Leibovitz's L-15不可以通入二氧化碳，会产生细胞毒性； 2、如您没有无二氧化碳的培养箱，可使用DMEM替代Leibovitz's L-15，使用DMEM培养基时即可正常通入5%二氧化碳； 3、配套专用培养基默认Leibovitz's L-15配置，如需DMEM配方，请联系销售下单备注更改。 |
| 背景描述 | MDA-MB-231来自患有转移乳腺腺癌的51岁女病人的胸水。 在裸鼠和ALS处理的BALB/c小鼠中，它能形成低分化腺癌（III级）。细胞表达WNT7B癌基因。 |
| 年龄（性别） | 女性，51岁 |
| 组织来源 | 乳腺腺癌，转移性胸膜渗出液 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 乳腺癌细胞 |
| 生物安全等级 | 1 |
| 倍增时间 | ~32-42小时 |
| 致瘤性 | Yes, in ALS treated BALB/c mice, forms poorly differentiated adenocarcinoma (grade III).Yes, in nude mice, forms poorly differentiated adenocarcinoma (grade III). |
| 受体表达情况 | epidermal growth factor (EGF), expressed;transforming growth factor alpha (TGF alpha), expressed |
| 保藏机构 | ATCC; CRL-12532ATCC; HTB-26 ATCC; CRM-HTB-26 BCRC; 60425 BCRJ; 0164 DSMZ; ACC-732 ECACC; 92020424 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12,13 D2S1338 20,21 D3S1358 16 D5S818 12 D7S820 8,9 D8S1179 13 D13S317 13 D16S539 12 D18S51 11,16 D19S433 11,14 D21S11 30,33.2 FGA 22,23 PentaD 11,14 PentaE 11 TH01 7,9.3 TPOX 8,9 vWA 15,18 D6S1043 18 D12S391 17,18 D2S441 14,15 -
STR鉴定图
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参考文献
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Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase(2021/08/05)
作者：Ximing Shao, Zhihao Ding, Wenhua Zhou
期刊：Nature Nanotechnology
DOI：10.1038/s41565-021-00952-x
影响因子 ：38.300
引用产品：CL-0016 CL-0101 CL-0103 CL-0150A CL-0150B CL-0236 CL-0238
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Mitochondria-targeted magnetic gold nanoheterostructure for multi-modal imaging guided photothermal and photodynamic therapy of triple-negative breast cancer(2020/07/24)
作者：Bo Li, Qian Zhou, Haiyang Wang
期刊：Chemical Engineering Journal
影响因子 ：15.100
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Zebrafish xenograft model for studying mechanism and treatment of non-small cell lung cancer brain metastasis(2021/11/20)
作者：Ruoyue Fan, Jiaqi Wu, Yuyang Liu
期刊：Journal Of Experimental & Clinical Cancer Research
DOI：10.1186/s13046-021-02173-5
影响因子 ：11.300
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Up-regulated circBACH2 contributes to cell proliferation, invasion, and migration of triple-negative breast cancer(2021/4/19)
作者：Xinxing Wang, Bingjian Xue, Yujie Zhang
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-03684-x
影响因子 ：9.000
引用产品：CL-0040 CL-0041 CL-0149 CL-0150A CL-0150B CL-0152A CL-0152B CL-0290A CL-0290B CL-0525
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MCPIP1-mediated NFIC alternative splicing inhibits proliferation of triple-negative breast cancer via cyclin D1-Rb-E2F1 axis(2021/04/06)
作者：Fengxia Chen, Qingqing Wang, Xiaoyan Yu
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-03661-4
影响因子 ：9.000
引用产品：CL-0005 CL-0041 CL-0114 CL-0150A CL-0150B CL-0380 CL-0525 PM150312B
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Phenotype-related drug sensitivity analysis of single CTCs for medicine evaluation(2020/08/10)
作者：Haimeng Pei, Mei Yu, Defang Dong
期刊：Chemical Science
影响因子 ：8.400
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A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy(2021/03/23)
作者：Hairong Wang, Yawen Zhang, Xiangle Zeng
期刊：International Journal of Nanomedicine
影响因子 ：8.000
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Therapeutic Effect of Doxorubicin-Chlorin E6-Loaded Mesoporous Silica Nanoparticles Combined with Ultrasound on Triple-Negative Breast Cancer(2020/04/21)
作者：Peng Xu, Jia Yao, Zhen Li
期刊：International Journal of Nanomedicine
影响因子 ：8.000
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Oxypalmatin regulates proliferation and apoptosis of breast cancer cells by inhibiting PI3K/AKT signaling and its efficacy against breast cancer organoids(2023/03/10)
作者：Xian Lin, Dong Chen, Xinyu Chu
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2023.154752
影响因子 ：7.900
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A self-assembled RNA-triple helix hydrogel drug delivery system targeting triple-negative breast cancer(2019/11/08)
作者：Lairong Ding, Junwei Li, Changrong Wu
期刊：Journal of Materials Chemistry B
影响因子 ：7.571
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Simultaneous Fluorescence Visualization of Epithelial-Mesenchymal Transition and Apoptosis Processes in Tumor Cells for Evaluating the Impact of Epithelial-Mesenchymal Transition on Drug Efficacy(2018/09/18)
作者：Mingming Luan, Jinjie Chang, Wei Pan
期刊：Analytical Chemistry
DOI：10.1021/acs.analchem.8b02494
影响因子 ：7.400
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Assessment of 2-allyl-4,5-dimethoxyphenol safety and attractiveness to mature males of Bactrocera dorsalis (Hendel)(2021/08/04)
作者：Shuzhen Deng, Xinyang Li, Ziming Wang
期刊：Ecotoxicology And Environmental Safety
DOI：10.1016/j.ecoenv.2021.112567
影响因子 ：6.800
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Small nucleolar RNA SNORA71A promotes epithelial-mesenchymal transition by maintaining ROCK2 mRNA stability in breast cancer(2022/03/30)
作者：Ting Hu, Chong Lu, Yun Xia
期刊：Molecular Oncology
影响因子 ：6.600
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UBE2C affects breast cancer proliferation through the AKT/mTOR signaling pathway(2021/10/20)
作者：Zinan Lu, Jia Song, Tonghui Sun
期刊：Chinese Medical Journal
DOI：10.1097/CM9.0000000000001708
影响因子 ：6.100
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CXCL9 influences the tumor immune microenvironment by stimulating JAK/STAT pathway in triple-negative breast cancer(2022/12/06)
作者：Lei Wu, Shengnan Sun, Fei Qu
期刊：CANCER IMMUNOLOGY IMMUNOTHERAPY
DOI：10.1007/s00262-022-03343-w
影响因子 ：5.800
引用产品：CL-0150A
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Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway(2019/10/07)
作者：Tianqi Li, Yudi Xiong, Qingqing Wang
期刊：Artificial Cells Nanomedicine and Biotechnology
DOI：10.1080/21691401.2019.1670670
影响因子 ：5.800
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Co-delivery of epirubicin and paclitaxel using an estrone-targeted PEGylated liposomal nanoparticle for breast cancer(2020/01/05)
作者：Huan Tang, Jinglin Chen, Lin Wang
期刊：International Journal of Pharmaceutics
DOI：10.1016/j.ijpharm.2019.118806
影响因子 ：5.800
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Dysfunction of the ST7-AS1/miR-301b-3p/BTG1 ceRNA network promotes immune escape of triple-negative breast cancer(2023/02/14)
作者：Yong Li, Wenge Xin, Fang Liu
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.109805
影响因子 ：5.600
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Weighted gene correlation network analysis identifies RSAD2, HERC5, and CCL8 as prognostic candidates for breast cancer(2019/06/21)
作者：Jianing Tang, Qian Yang, Qiuxia Cui
期刊：Journal Of Cellular Physiology
影响因子 ：5.600
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Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis | Molecular and Cellular Biology(2021/9/24)
作者：Yihong Huang, Shuo Zheng, Ying Lin, Liming Kea
期刊：Molecular And Cellular Biology
影响因子 ：5.300
引用产品：164210 CL-0041 CL-0150A CL-0152A CL-0290A CL-0525 PB180120 PM150110 PM151010
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The curcumin analog EF24 inhibits proliferation and invasion of triple-negative breast cancer cells by targeting the lncRNA HCG11/Sp1 axis | Molecular and Cellular Biology(2021/11/15)
作者：Yin Duan, Huiling Chen, Min Ling
期刊：Molecular And Cellular Biology
影响因子 ：5.300
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Enzymatic rhamnosylation of anticancer drugs by an α-l-rhamnosidase from Alternaria sp. L1 for cancer-targeting and enzyme-activated prodrug therapy(2019/08/08)
作者：Li Xu , Xiaohong Liu , Yinping Li
期刊：Applied Microbiology And Biotechnology
DOI：10.1007/s00253-019-10011-0
影响因子 ：5.000
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Fat mass and obesity-associated protein (FTO) mediates signal transducer and activator of transcription 3 (STAT3)-drived resistance of breast cancer to doxorubicin(2021/6/2)
作者：Yan Wang, Zhiqiang Cheng, Jing Xu
期刊：Bioengineered
DOI：10.1080/21655979.2021.1924544
影响因子 ：4.900
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Possible involvement of TGF‑β‑SMAD‑mediated epithelial‑mesenchymal transition in pro‑metastatic property of PAX6(2020/06/11)
作者：Meng Jin, Daili Gao, Rongchun Wang
期刊：Oncology Reports
影响因子 ：4.200
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Mesothelin-targeted CAR-NK Cells Derived From Induced Pluripotent Stem Cells Have a High Efficacy in Killing Triple-negative Breast Cancer Cells as Shown in Several Preclinical Models(2023/08/15)
作者：Mei Yang, Tian Guan, Chunfa Chen
期刊：JOURNAL OF IMMUNOTHERAPY
DOI：10.1097/CJI.0000000000000483
影响因子 ：3.900
引用产品：CL-0150A
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Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell(2019/08/14)
作者：Mingjiang Yao, Xiaodi Fan, Bo Yuan
期刊：BMC Complementary and Alternative Medicine volume
影响因子 ：3.900
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Ferroptosis regulators, especially SQLE, play an important role in prognosis, progression and immune environment of breast cancer(2021/10/29)
作者：Wenqing Tang, Fangshi Xu, Meng Zhao
期刊：Bmc Cancer
DOI：10.1186/s12885-021-08892-4
影响因子 ：3.800
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The Antitumor Potential of Extract of the Oak Bracket Medicinal Mushroom Inonotus baumii in SMMC-7721 Tumor Cells(2019/09/22)
作者：Yue Yang, Pingya He
期刊：Evidence-Based Complementary and Alternative Medicine
影响因子 ：2.650
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Hsa_circ_0069094 positively regulates the expression of oncogenic ZNF217 by competitively targeting miR-758–3p to promote the development of breast cancer(2022/11/08)
作者：Huaqing Ou, Jialing Li, Qinhua Lv, Decai Feng
期刊：Reproductive Biology
DOI：10.1016/j.repbio.2022.100708
影响因子 ：2.100
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Lidocaine prevents breast cancer growth by targeting neuronatin to inhibit nerve fibers formation(2021/7/1)
作者：Bingda Li, Hao Xu, Chongwu He
期刊：Journal Of Toxicological Sciences
影响因子 ：2.000
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DNAJB4 identified as a potential breast cancer marker: evidence from bioinformatics analysis and basic experiments(2020/12/1)
作者：Linlong Mo, Jiayou Liu, Ziquan Yang
期刊：Gland Surgery
影响因子 ：1.800
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CircRNA DNA methyltransferase 1 silence inhibits breast cancer development by regulating micoRNA-485-3p/zinc finger E-box binding homeobox 1 axis(2021/01/05)
作者：Chen Xie, Junyu Li, Chen Xu
期刊：Journal Of Obstetrics And Gynaecology Research
影响因子 ：1.600
