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产品概述
| 名称 | NIH:OVCAR-3 [OVCAR3] (人卵巢癌细胞) (STR鉴定正确) |
| 别称 | Ovcar-3; NIH:OVCAR-3; NIH:Ovcar-3; NIH:OVCAR3; NIH-OVCAR-3; NIHOVCAR3; OVCAR.3; OVCAR3; Ovcar3 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 生长培养基 | RPMI-1640＋20% FBS＋0.01mg/ml Insulin＋1% P/S |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2~3次/周 |
| 背景描述 | NIH:OVCAR-3 [OVCAR3]细胞是由T·C·Hamilton在1982年建系，NIH:OVCAR-3 [OVCAR3]细胞取材于患进行性卵巢腺癌病人的恶性腹水。NIH:OVCAR-3 [OVCAR3]细胞与107细胞联合皮下接种5只裸鼠21天后全部成瘤。NIH:OVCAR-3 [OVCAR3]细胞是研究卵巢癌药物抗性的一个合适的模型系统且由于存在激素受体，这对于激素治疗的评估或许是有用的。 |
| 年龄（性别） | 女；60岁 |
| 组织来源 | 卵巢腺癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 卵巢癌细胞 |
| 生物安全等级 | 1 |
| 倍增时间 | ~35-64 hours |
| 致瘤性 | Yes, Forms colonies in soft agar.Yes, in nude mice inoculated subcutaneously with 1×10^7 cells (Tumors developed within 21 days at 100% frequency (5/5)). |
| 受体表达情况 | Androgen receptor, positive;estrogen receptor, positive;progesterone receptor, positive |
| 保藏机构 | ATCC; HTB-161 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11,12 D2S1338 17,21 D3S1358 17,18 D5S818 11,12 D7S820 10 D8S1179 10,15 D13S317 12 D16S539 12 D18S51 13 D19S433 16.2 D21S11 29,31.2 FGA 21 PentaD 12,13 PentaE 7,13 TH01 9 TPOX 8 vWA 17 D6S1043 10,11 D12S391 19,22 D2S441 11,14 -
STR鉴定图
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参考文献
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circ_0025033 promotes ovarian cancer development via regulating the hsa_miR-370-3p/SLC1A5 axis(2022/10/22)
作者：Huiping Ma, Shuyun Qu, Yao Zhai
期刊：CELLULAR & MOLECULAR BIOLOGY LETTERS
DOI：10.1186/s11658-022-00364-2
影响因子 ：8.7020
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A 19F NMR probe for the detection of β-galactosidase: simple structure with low molecular weight of 274.2, “turn-on” signal without the background, and good performance applicable in cancer cell line(2017/06/28)
作者：Jie Hu, Qiong Wu, Kai Cheng
期刊：J Mater Chem B
影响因子 ：7.571
引用产品：CL-0178
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Isothiocyanate Iberin inhibits cell proliferation and induces cell apoptosis in the progression of ovarian cancer by mediating ROS accumulation and GPX1 expression(2021/06/17)
作者：Tingting Gong, Qian Guo, Xiao Li
期刊：Biomedicine & Pharmacotherapy
DOI：10.1016/j.biopha.2021.111533
影响因子 ：7.419
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PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib(2022/09/05)
作者：Xiaocui Zhang, Meige Sun, Yisheng Jiao
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：7.3100
引用产品：164210 164210-50 CL-0013 CL-0079 CL-0178 P-CA-161 PM150110 PM150710
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CircLNPEP promotes the progression of ovarian cancer through regulating miR-876-3p/ WNT5A axis(2021/08/31)
作者：Wenwen Wang, Weiwei Zhang, Hongjun Guo
期刊：Cell Cycle
DOI：10.1080/15384101.2021.1965723
影响因子 ：5.173
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P76RBE silencing inhibits ovarian cancer cell proliferation, migration, and invasion via suppressing the integrin β1/NF-κB pathway(2021/08/12)
作者：Limei Yan, Zeping He, Wei Li
期刊：Cell Cycle
DOI：10.1080/15384101.2021.1963910
影响因子 ：5.1730
引用产品：CL-0013 CL-0178 CL-0215 CL-0626 CM-0178 CM-0626 CM-H055 CP-H055
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Norcantharidin induces ferroptosis via the suppression of NRF2/HO‑1 signaling in ovarian cancer cells(2022/08/25)
作者：Xiaoyan Zhu, Xiaohong Chen, Longshan Qiu
期刊：Oncology Letters
影响因子 ：3.1110
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miR‑638 suppresses proliferation by negatively regulating high mobility group A1 in ovarian cancer cells(2021/9/20)
作者：Li Ma, Wei Zhang, Yaofeng Jin
期刊：Experimental and Therapeutic Medicine
影响因子 ：2.7510
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Circ_0021573 acts as a competing endogenous RNA to promote the malignant phenotypes of human ovarian cancer cells(2022/12/05)
作者：Lifang Liu, Bingkai Han, Lixia Liu
期刊：Reproductive Biology
DOI：10.1016/j.repbio.2022.100704
影响因子 ：2.0890
引用产品：164210 164210-50 CL-0005 CL-0013 CL-0079 CL-0178 CL-0215 PB180120 PM150110
