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产品概述
名称 | SK-Hep-1 (人肝癌细胞) (STR鉴定正确) |
别称 | SK-Hep-1; SK HEP-1; SK HEP 01; SK-Hep1; Sk-Hep1; SK Hep1; SKHEP-1; SKHEP1; SKHep1; SK_HEP1 |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
生长培养基 | MEM(含NEAA)+10% FBS+1% P/S |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养条件 | 气相:空气,95%;CO2,5% 温度:37℃ |
推荐传代比例 | 1:2-1:4 |
推荐换液频率 | 2~3次/周 |
背景描述 | SK-HEP-1细胞已被鉴定为内皮来源。SK-HEP-1细胞来源于52岁男性,染色体在亚三倍体范围内。在裸鼠中,SK-HEP-1细胞能形成与肝癌相一致的大细胞癌。 |
年龄(性别) | 男;52岁 |
组织来源 | 腺癌,肝,腹水 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 肝胆癌细胞 |
生物安全等级 | 1 |
倍增时间 | ~30 hours |
致瘤性 | Yes, in nude mice; forms large cell carcinoma consistent with hepatoma. |
保藏机构 | ATCC; HTB-52 DSMZ; ACC-141 ECACC; 91091816 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11,12 D2S1338 20,23 D3S1358 16 D5S818 10,13 D7S820 8,11 D8S1179 13,14 D13S317 8,12 D16S539 12 D18S51 13,15 D19S433 12,15.2 D21S11 29,31 FGA 17 PentaD 13,14 PentaE 13,21 TH01 7,9 TPOX 9 vWA 14,17 D6S1043 11 D12S391 18,19 D2S441 12.3,14 -
STR鉴定图
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参考文献
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SGOL2 is a novel prognostic marker and fosters disease progression via a MAD2-mediated pathway in hepatocellular carcinoma(2022/11/15)
作者:Hu, Qingqing, Liu, Qiuhong, Zhao, Yalei, Zhang, Lingjian, Li, Lanjuan
期刊:Biomarker Research
DOI:10.1186/s40364-022-00422-z
影响因子 :11.100
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Neuropilin-1 aggravates liver cirrhosis by promoting angiogenesis via VEGFR2-dependent PI3K/Akt pathway in hepatic sinusoidal endothelial cells(2019/05/03)
作者:Le Wang, Yuemin Feng, Xiaoyu Xie
期刊:EBioMedicine
DOI:10.1016/j.ebiom.2019.04.050
影响因子 :11.100
引用产品:CL-0212
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Nanoparticle-Stabilized Emulsion Bioink for Digital Light Processing Based 3D Bioprinting of Porous Tissue Constructs(2022/03/04)
作者:Jie Tao, Shunyao Zhu, Nazi Zhou
期刊:Advanced Healthcare Materials
影响因子 :11.092
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ncRNAs-mediated high expression of TICRR promotes tumor cell proliferation and migration and is correlated with poor prognosis and tumor immune infiltration of hepatocellular carcinoma(2022/09/19)
作者:Kejie He, Yangfan Zhang, Laiying Liang
期刊:Molecular Therapy-Nucleic Acids
DOI:10.1016/j.omtn.2022.09.007
影响因子 :8.800
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Comprehensive analysis of ubiquitin‐specific protease 1 reveals its importance in hepatocellular carcinoma(2020/09/19)
作者:Yalei Zhao, Chen Xue, Zhongyang Xie
期刊:Cell Proliferation
影响因子 :8.500
引用产品:CL-0212
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LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway(2021/11/27)
作者:Ying Xing,Yang Liu,Zhong Qi
期刊:Cellular & Molecular Biology Letters
DOI:10.1186/s11658-021-00295-4
影响因子 :8.300
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5′-tiRNA-Gln inhibits hepatocellular carcinoma progression by repressing translation through the interaction with eukaryotic initiation factor 4A-I(2023/03/28)
作者:Chengdong Wu, Dekai Liu, Lufei Zhang
期刊:Frontiers of Medicine
影响因子 :8.100
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Identification and analysis of C17orf53 as a prognostic signature for hepatocellular carcinoma(2022/11/28)
作者:Yalei Zhao, Lingjian Zhang, Qingqing Hu, Danhua Zhu, Zhongyang Xie
期刊:COMPUTERS IN BIOLOGY AND MEDICINE
DOI:10.1016/j.compbiomed.2022.106348
影响因子 :7.700
引用产品:CL-0212
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Dual role of PID1 in regulating apoptosis induced by distinct anticancer-agents through AKT/Raf-1-dependent pathway in hepatocellular carcinoma(2023/04/28)
作者:Jian Yang, Senlin Li, Jialuo He
期刊:Cell Death Discovery
DOI:10.1038/s41420-023-01405-1
影响因子 :7.000
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VEZF1, destabilized by STUB1, affects cellular growth and metastasis of hepatocellular carcinoma by transcriptionally regulating PAQR4(2022/10/14)
作者:Xiaobao Shi, Pengfei Zhao, Gang Zhao
期刊:Cancer Gene Therapy
DOI:10.1038/s41417-022-00540-8
影响因子 :6.400
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CRHBP is degraded via autophagy and exerts anti-hepatocellular carcinoma effects by reducing cyclin B2 expression and dissociating cyclin B2-CDK1 complex(2022/01/27)
作者:Zhiwei Wang, Mingxing Li, Yuanfeng Liu
期刊:Cancer Gene Therapy
DOI:10.1038/s41417-021-00423-4
影响因子 :5.854
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Bufalin enhances the killing efficacy of NK cells against hepatocellular carcinoma by inhibiting MICA shedding(2021/10/19)
作者:Rao Fu, Fangjing Yu, Weiqi Wu
期刊:International Immunopharmacology
DOI:10.1016/j.intimp.2021.108195
影响因子 :5.714
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Celecoxib reduces hepatic vascular resistance in portal hypertension by amelioration of endothelial oxidative stress(2021/10/05)
作者:Yang Tai, Chong Zhao, Linhao Zhang
期刊:Journal Of Cellular And Molecular Medicine
影响因子 :5.300
引用产品:CL-0212
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PI3K δ inhibitor PI-3065 induces apoptosis in hepatocellular carcinoma cells by targeting survivin(2023/01/06)
作者:Yuze Wei, Weiwei Ke, Zaiming Lu
期刊:CHEMICO-BIOLOGICAL INTERACTIONS
影响因子 :5.100
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Daphnetin inhibits the survival of hepatocellular carcinoma cells through regulating Wnt/β-catenin signaling pathway(2022/02/07)
作者:Chaohui Liu, Jiansheng Pan, Hongyu Liu
期刊:Drug Development Research
影响因子 :5.004
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Improving the antitumor efficiency against hepatocellular carcinoma by harmine-loaded liposomes with mitochondria targeting and legumain response(2022/08/01)
作者:Ipargul Hafiz, Zhezhe Li, Zhaozhi Wang
期刊:JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
DOI:10.1016/j.jddst.2022.103623
影响因子 :5.000
引用产品:CL-0212
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Tumor purity–associated genes influence hepatocellular carcinoma prognosis and tumor microenvironment(2023/06/26)
作者:Yan Zhao, Xu Xu, Yue Wang
期刊:Frontiers in Oncology
影响因子 :4.700
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Circ_0007429/miR-637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC(2023/03/15)
作者:Lilan Fan, Panpan Xia, Jing Wang
期刊:MOLECULAR CARCINOGENESIS
DOI:10.1002/mc.23526
影响因子 :4.600
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LncRNA KCNQ1OT1 inhibits the radiosensitivity and promotes the tumorigenesis of hepatocellular carcinoma via the miR-146a-5p/ACER3 axis(2020/09/16)
作者:Ganghua Yang, Lijing Zhou, Qinhong Xu
期刊:Cell Cycle
DOI:10.1080/15384101.2020.1809259
影响因子 :4.300
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Antipsychotic agent pimozide promotes reversible proliferative suppression by inducing cellular quiescence in liver cancer(2019/07/11)
作者:Jiajie Chen, Lina Zhang, Nan Cai
期刊:Oncology Reports
影响因子 :4.200
引用产品:CL-0212
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PAQR4 promotes the development of hepatocellular carcinoma by activating PI3K/AKT pathway(2021/10/30)
作者:Gang Zhao, Xiaobao Shi, Zhanbo Sun
期刊:Acta Biochimica Et Biophysica Sinica
影响因子 :3.511
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Long noncoding RNA HAND2-AS1 reduced the viability of hepatocellular carcinoma via targeting microRNA-300/SOCS5 axis(202/3/12)
作者:Huaqiang Bi, Zhonghui Li, Hui Zhang
期刊:Hepatobiliary & Pancreatic Diseases International
DOI:10.1016/j.hbpd.2020.02.011.
影响因子 :3.300
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Lysine demethylase 5C epigenetically reduces transcription of ITIH1 that results in augmented progression of liver hepatocellular carcinoma(2022/01/25)
作者:Xu Qian, Zhongming Bao, Dan Yao
期刊:Kaohsiung Journal of Medical Sciences
影响因子 :3.300
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Long non-coding RNA AK058003, as a precursor of miR-15a, interacts with HuR to inhibit the expression of Υ-synuclein in hepatocellular carcinoma cells(2016/12/27)
作者:Xiaoqin He, Yongfa Zheng, Yuefeng Zhang
期刊:Oncotarget
影响因子 :0.000