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当前位置:首页 >> 产品中心 >> 辅助试剂 >> 细胞因子 >> Human

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  • Procell-HGF R/ c-Met/ HGFR, Human, Recombinant

HGF R/ c-Met/ HGFR, Human, Recombinant

货号:PCK027

价格:¥1280¥2980¥17480¥25680

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Hepatocyte Growth Factor Receptor; HGF Receptor; HGF/ SF Receptor; Proto-oncogene c-Met; Scatter factor Receptor; SF Receptor; Tyrosine- Protein kinase Met; MET
物种 Human
表达宿主 Human Cells
序列信息 Glu25-Gly519
检索号 P08581
分子量 56.9 kDa
表观分子量 32&35-57 kDa
标签 C-6His

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2~8℃ for 2~7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输 Ambient temperature or ice pack.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled waterPlease aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Hepatocyte Growth Factor Receptor (HGF R) is a glycosylated Receptor tyrosine kinase that plays a central role in epithelial morphogenesis and cancer development. HGF R is synthesized as a single chain precursor which undergoes cotranslational proteolytic cleavage. Mature HGF R is a disulfide-linked dimer composed of a 50 kDa extracellular α chain and a 145 kDa transmembrane β chain. Proteolysis and alternate splicing generate additional forms of human HGF R which either lack of the kinase domain, consist of secreted extracellular domains, or are deficient in proteolytic separation of the α and β chains. The sema domain, which is formed by both α and β chains of HGF R, mediates both Ligand binding and Receptor dimerization. HGF stimulation induces HGF R downregulation via internalization and proteasomedependent degradation. Paracrine induction of epithelial cell scattering and branching tubulogenesis results from the stimulation of HGF R on undifferentiated epithelium by HGF released from neighboring mesenchymal cells.
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