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  • Procell-IL-4/ BSF-1 (C-6His), Mouse, Recombinant
  • Procell-IL-4/ BSF-1 (C-6His), Mouse, Recombinant

IL-4/ BSF-1 (C-6His), Mouse, Recombinant

货号:PCK034

价格:¥1380¥3680¥17480¥25680

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Interleukin-4; IL-4; IL4; B-cell IgG differentiation factor; B-cell Growth Factor 1; B-cell stimulatory factor 1; BSF-1; IGG1 induction factor; Lymphocyte stimulatory factor 1
物种 Mouse
表达宿主 Human Cells
序列信息 His21-Ser140
检索号 P07750
分子量 14.6 kDa
表观分子量 15-19 kDa
标签 C-6His
生物活性 Measured in a cell proliferation assay using M-NFS-60 mouse lymphoblast cells. The ED50 for this effect is 0.035 ng/mL.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 <1.0 EU per µg as determined by LAL test.
保存 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2~8℃ for 2~7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输 Ambient temperature or ice pack.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Interleukin-4 (IL-4) is a pleiotropic Cytokine that regulates diverse T and B cell responses including cell proliferation, survival and gene expression. IL-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of naive CD4+ T cells into helper Th2 cells, characterized by their Cytokine-secretion profile that includes secretion of IL-4, IL-5, IL-6, IL-10, and IL-13, which favor a humoral immune response. Another dominant function of IL-4 is the regulation of immunoglobulin class switching to the IgG1 and IgE isotypes. Excessive IL-4 production by Th2 cells has been associated with elevated IgE production and allergic response.
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