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  • Procell-Interferon γ/ IFN-γ/ IFNG, Mouse, Recombinant

Interferon γ/ IFN-γ/ IFNG, Mouse, Recombinant

货号:PCK064

价格:¥1280¥2980¥7880¥12380

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Ifng; Interferon gamma; IFN-gamma
物种 Mouse
表达宿主 E.coli
序列信息 His23-Cys155
检索号 P01580
分子量 15.7 kDa
表观分子量 14 kDa
生物活性 Determined by its ability to inhibit the proliferation of murine WEHI-279 cells. The ED50 for this effect is 1 ng/mL.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 4mM HCl.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in 4mM HCl. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Mouse Ifng is a secreted Protein which belongs to the type I I (or gamma) interferon family. IFNG is produced by lymphocytes and activated by specific antigens or mitogens. In addition to having antiviral activity, IFNG also has important immunoregulatory functions. It is a potent activator of macrophages and has antiproliferative effects on transformed cells. It can potentiate the antiviral and antitumor effects of the type I interferons. Genetic variation in IFNG is associated with the risk of aplastic anemia (AA) which is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete Cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
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