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  • Procell-β-NGF/ NGF/ NGFB (Ser122-Arg239, Cells), Human, Recombinant

β-NGF/ NGF/ NGFB (Ser122-Arg239, Cells), Human, Recombinant

货号:PCK071

价格:¥500¥1180¥6880¥11180

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB
物种 Human
表达宿主 Human Cells
序列信息 Ser122-Arg239
检索号 P01138
分子量 13.5 kDa
表观分子量 15 kDa
生物活性 Measured in a cell proliferation assay using TF‑1 human erythroleukemic cellsThe ED50 for this effect is less than 2 ng/ ml.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB, 250mM NaCl, pH 7.0.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Human β-Nerve Growth Factor (β-NGF) was initially isolated in the mouse submandibular gland. It is composed of three non-covalently linked subunits α, β, and γ; it exhibits all the biological activities ascribed to NGF. It is structurally related to BDNF, NT-3 and NT-4 and belongs to the cysteine-knot family of Growth Factors that assume stable dimeric structures. Β-NGF is a neurotrophic factor that signals through its Receptor β-NGF, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. These results suggest that β-NGF is a pleiotropic Cytokine, which in addition to its neurotropic activities may have an important role in the regulation of the immune system. Human β-NGF shares 90% sequence similarity with mouse Protein and shows cross-species reactivity.
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