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  • Procell-β-NGF/ NGF/ NGFB (Met130-Arg239), Mouse, Recombinant

β-NGF/ NGF/ NGFB (Met130-Arg239), Mouse, Recombinant

货号:PCK072

价格:¥780¥1380¥7880¥12380

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Beta-Nerve Growth Factor; Beta-NGF; NGF; NGFB
物种 Mouse
表达宿主 E.coli
序列信息 Met130-Arg239
检索号 P01139
分子量 12.4 kDa
表观分子量 12 kDa
生物活性 Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells.The ED50 for this effect is 68.52 ng/ml.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 0.1 ng/ug (1 EU/ug) as determined by LAL test.
保存 Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB,200mM NaCl,pH 8.0.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

NGF is the first member discovered in the Neurotrophin family, which includes brain-Derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4). These Proteins belong to the cysteine-knot family of Growth Factors that assume stable dimeric structures. Mouse beta -NGF is a homodimer of two 120 amino acid polypeptides. It shares approximately 90% homology at the amino acid level with human beta -NGF and 95.8% with rat beta -NGF. NGF signaling has been shown to play an important role in neuroprotection and repair. β-NGF acts as a growth and differentiation factor for B lymphocytes, and enhances B-cell survival. It is a potent neurotrophic factor that signals through its Receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems.
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