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产品概述
产品信息
| 别名 | Interleukin-3 Receptor subunit alpha; IL-3 Receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Thr19-Arg305 |
| 检索号 | P26951 |
| 分子量 | 60 kDa |
| 表观分子量 | 80-100kDa |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
CD123, also known as Interleukin-3 Receptor subunit alpha, belongs to the type I Cytokine Receptor family. In mouse, there are two classes of high-affinity IL3 Receptors. One contains an IL3-specific beta subunit and the other contains the beta subunit also shared by high-affinity IL5 and GM-CSF Receptors. CD123 stimulates the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as various lineage-committed cells. CD123 is a heterodimer consisting of an alpha and a beta subunit. The alpha subunit alone binds IL-3 with low affinity. The beta subunit does not bind IL-3 by itself but is required for the high-affinity binding of IL-3 to the heterodimeric Receptor complex.
