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当前位置:首页 >> 产品中心 >> 辅助试剂 >> 细胞因子 >> Human

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  • Procell-IL-7 (C-6His), Human, Recombinant

IL-7 (C-6His), Human, Recombinant

货号:PCK080

价格:¥1780¥4980¥18980¥27980

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Interleukin-7; IL-7; IL7
物种 Human
表达宿主 Human Cells
序列信息 Asp26-His177
检索号 P13232
分子量 18.4 kDa
表观分子量 25 kDa
标签 C-6His
生物活性 Measured in a cell proliferation assay using PHA-activated human peripheral blood lymphocytes (PBL)The ED50 for this effect is less than 5 ng/ ml.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH 7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Human Interleukin 7 (IL-7) is a potent lymphoid cell Growth Factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte Growth Factor (HGF) to form a hybrid Cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor Protein containing a 25 amino acid signal peptide and a 152 amino acid mature Protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-species activity. IL-7 signals via IL-7 Receptor (IL7R) activating multiple pathways including JaK/ STAT and PI3K/ AKT, which regulate lymphocyte survival, glucose uptake, proliferation, and differentiation. IL-7 is also associated with cytoplasmic IL2-R gamma for signal transduction.
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