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当前位置:首页 >> 产品中心 >> 辅助试剂 >> 细胞因子 >> Mouse

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  • Procell-TPO/ THPO (N-6His), Mouse, Recombinant

TPO/ THPO (N-6His), Mouse, Recombinant

货号:PCK098

价格:¥1780¥4980¥18980¥27980

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Thrombopoietin; C-mpl Ligand; Megakaryocyte colony-stimulating factor; Megakaryocyte growth and development factor; Myeloproliferative leukemia virus oncogene Ligand; THPO
物种 Mouse
表达宿主 Human Cells
序列信息 Ser22-Thr356
检索号 P40226
分子量 36.4 kDa
表观分子量 65-105 kDa
标签 N-6His

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months.
运输 Ambient temperature or ice pack.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, 2mM EDTA, pH 7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Thrombopoietin (TPO) is a glyco Protein hormone which belongs to the EPO/ TPO family. It produced by the liver and kidney which regulates the production of platelets.Mature mouse Tpo shares 71% and 81% aa sequence homology with human and rat Tpo, respectively. It is an 80-85 kDa Protein that consists of an N-terminal domain with homology to Erythropoietin (Epo) and a C-terminal domain that contains multiple N-linked and O-linked glycosylation sites. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific Cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
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