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产品概述
产品信息
| 别名 | Activin Receptor Type-2A; Activin Receptor Type IIA; ACTR-IIA; ACTRIIA; ACVR2A; ACVR2 |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Ala20-Pro134 |
| 检索号 | P27037 |
| 分子量 | 14.35 kDa |
| 表观分子量 | 32 kDa |
| 生物活性 | Testing in progress |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4. |
| 复融 | Dissolve the lyophilized protein in distilled water. |
背景介绍
Activin Receptor Type-2A is a Protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activintype 2 Receptor. This gene encodes activin A type II Receptor. Activins are dimeric growth anddifferentiation factors which belong to the transforming Growth Factor-beta (TGF-beta) superfamily ofstructurally related signaling Proteins. Activins signal through a heteromeric complex of Receptor serinekinases which include at least two type I (I and IB) and two type II (II and IIB) Receptors. These Receptors areall transmembrane Proteins, composed of a Ligand-binding extracellular domain with cysteine-rich region, atransmembrane domain, and a cytoplasmic domain with predicted serine/ threonine specificity. Type IReceptors are essential for signaling; and type II Receptors are required for binding Ligands and forexpression of type I Receptors. Type I and II Receptors form a stable complex after Ligand binding, resultingin phosphorylation of type I Receptors by type II Receptors. Type II Receptors are considered to beconstitutively active kinases.
