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产品概述
产品信息
| 别名 | Tumor necrosis factor Receptor superfamily member 17; TNFRSF17; B-cell maturation Protein; CD269 |
| 物种 | Human |
| 表达宿主 | Human Cells |
| 序列信息 | Met1-Ala54 |
| 检索号 | Q02223 |
| 分子量 | 32.8kDa |
| 表观分子量 | 38-40kDa |
| 生物活性 | Loaded Mouse BAFF-mFc on AMC Biosensor, can bind Human BCMA-Fc with an affinity constant of 0.44 nM as determined in BLI assay. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized protein should be stored at -5~-20℃, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at -5~-20℃ for 3 months. |
| 运输 | Ambient temperature or ice pack. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of PBS,pH 7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting.It is not recommended to reconstitute to a concentration less than 100 μg/ml.Dissolve the lyophilized protein in distilled water.Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
B cell maturation Protein (BCMA) is a type III membrane Protein which belongs to the TNF Receptor superfamily (TNFRSF17). BCMA contains one extracellular cysteine rich domain, as well as TACI. Human BCMA is a 184 amino acid (aa) Protein consisting of a 54 aa extracellular domain, a 23 aa transmembrane domain, and a 107 aa intracellular domain. Mouse and human BCMA share 62% amino acid identity. BCMA is mainly expressed in immune organs and mature B cell lines. BCMA appears to be localized to the Golgi compartment. BCMA may play an important role in B cell development, function and regulation.
