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当前位置:首页 >> 产品中心 >> 辅助试剂 >> 细胞因子 >> Human

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  • Procell-MCP-1/ CCL2, Human, Recombinant

MCP-1/ CCL2, Human, Recombinant

货号:PCK111

价格:¥1780¥4980¥18980¥27980

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 C-C Motif Chemokine 2; HC11; Monocyte chemoattractant Protein 1; Monocyte chemotactic and activating factor; MCAF; Monocyte chemotactic Protein 1; MCP-1; Monocyte secretory Protein JE; Small-inducible Cytokine A2; CCL2
物种 Human
表达宿主 E.coli
序列信息 Gln24-Thr99
检索号 P13500
分子量 8.7 kDa
表观分子量 13 kDa
生物活性 Testing in progress

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

The Chemokine (C-C Motif) Ligand 2 (CCL2), also known as monocyte chemoattractant Protein (MCP)-1 and small inducible Cytokine A2 (SCYA2)), is a small Cytokine that belongs to the CC Chemokine family responsible for monocyte attraction. Its cognate Receptor, CCR2, play a critical role in regulating nociceptive processes during neuropathic pain. Both CCL2 and CCR2 are implicated in induction of autoimmunity. CCL2 recruits monocytes, memory T cells, and dendritic cells to the sites of inflammation produced by either tissue injury or infection. Recently research also showed that CCL2 might be useful as a biomarker of fibrosis as well as a target for therapeutic intervention.
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