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当前位置:首页 >> 产品中心 >> 辅助试剂 >> 细胞因子 >> Human

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  • Procell-FGFR-3/ CD333/ FGFR3 (C-Fc), Human, Recombinant

FGFR-3/ CD333/ FGFR3 (C-Fc), Human, Recombinant

货号:PCK140

价格:¥980¥1880¥11980¥17280

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Fibroblast Growth Factor Receptor 3; FGFR-3; CD333; FGFR3; JTK4; IIIc
物种 Human
表达宿主 Human Cells
序列信息 Glu23-Gly375
检索号 P22607
分子量 64.8 kDa
表观分子量 95-110 kDa
生物活性 Measured by its ability to inhibit FGF acidic-dependent proliferation of BALB/ c 3T3 cells.The ED50爁or this effect is less than 100 ng/ ml.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Fibroblast Growth Factors (FGFs) are involved in a multitude of physiological and pathological cellular processes. The biological activities of the FGFs are mediated by a family of type I transmembrane tyrosine kinases which undergo dimerization and autophosphorylation after Ligand binding. Four distinct genes encoding closely related FGF Receptors, FGF R1-4, are known. All four genes for FGF Rs encode Proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid-box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain. Multiple forms of FGF R1-3 are generated by alternative splicing of the mRNAs. A frequent splicing event involving FGF R1 and 2 results in Receptors containing all three Ig domains, referred to as the α isoform, or only IgII and IgIII, referred to as the β isoform. Only the α isoform has been identified for FGF R3 and FGF R4. Additional splicing events for FGF R1-3, involving the C-terminal half of the IgIII domain encoded by two mutually exclusive alternative exons, generate FGF Receptors with alternative IgIII domains (IIIb and IIIc). The complex patterns of expression of these Receptors as well as the specificity of their interactions with the various FGF Ligand family members are under investigation.
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