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当前位置:首页 >> 产品中心 >> 辅助试剂 >> 细胞因子 >> Human

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  • Procell-GITR/ TNFRSF18/ CD357 (C-6His), Human, Recombinant

GITR/ TNFRSF18/ CD357 (C-6His), Human, Recombinant

货号:PCK141

价格:¥1380¥3680¥17480¥25680

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Tumor necrosis factor Ligand superfamily member 18; TNFSF18; Activation-inducible TNF-related Ligand; Glucocorticoid-induced TNF-related Ligand; AITRL; GITRL; TL6
物种 Human
表达宿主 Human Cells
序列信息 Glu74-Ser199
检索号 Q9UNG2
分子量 15.3 kDa
表观分子量 16 &18 kDa
标签 C-6His
生物活性 Testing in progress

产品特性

纯度 >90% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

TNFSF18 is a single-pass type II membrane Protein. It is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 Cytokine binds to TNFRSF18/ AITR/ GITR. It regulates T-cell responses, and functions as costimulator and lower the threshold for T-cell activation and T-cell proliferation. It is Important for interactions between activated T-lymphocytes and endothelial cells and Promotes leukocyte adhesion to endothelial cells. TNFSF18 mediates activation of NF-kappa-B. As Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. It also regulates migration of monocytes from the splenic reservoir to sites of inflammation.
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