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  • Procell-IL-1RAcP/ IL-1R3/ IL-1F6 (C-Fc-6His), Human, Recombinant

IL-1RAcP/ IL-1R3/ IL-1F6 (C-Fc-6His), Human, Recombinant

货号:PCK143

价格:¥780¥1380¥7880¥12380

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Interleukin-1 Receptor Accessory Protein; IL-1 Receptor Accessory Protein; IL-1RAcP; Interleukin-1 Receptor 3; IL-1R-3; IL-1R3; IL1RAP; C3orf13; IL1R3
物种 Human
表达宿主 Human Cells
序列信息 Ser21-Gln356
检索号 Q9NPH3
分子量 39.7 kDa
表观分子量 82 kDa
标签 C-Fc-6His
生物活性 Testing in progress

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Interleukin-1 Receptor Accessory Protein (IL-1RAcP) is a member of the Interleukin-1 Receptor family. It contains three Ig-like C2-type domains in the extracellular region and a long cytoplasmic domain implicated in signal transduction. IL-1RAcP acts as a non-Ligand binding accessory component of the Receptors for IL1α, IL1βand IL33. IL-1RAcP mediates Interleukin-1-dependent activation of NF-kappa-B. It is part of the membrane-bound form of the IL-1 Receptor. IL-1 RAcP takes part in the Signaling ways by the formation of a ternary complex containing IL1R1, TOLLIP, MYD88, and IRAK1 or IRAK2. In addition, IL-1RAcP modulates the response to Interleukins by associating with soluble IL1R1 and enhancing Interleukin-binding to the decoy Receptor.
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