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当前位置:首页 >> 产品中心 >> 辅助试剂 >> 细胞因子 >> Human

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  • Procell-IL-1R-1/ CD121a (C-Fc), Human, Recombinant

IL-1R-1/ CD121a (C-Fc), Human, Recombinant

货号:PCK145

价格:¥1280¥2980¥17480¥25680

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Interleukin-1 Receptor type 1; IL-1R-1; IL-1RT-1; IL-1RT1; CD121 antigen-like family member A; Interleukin-1 Receptor alpha; IL-1R-alpha; p80; CD121a
物种 Human
表达宿主 Human Cells
序列信息 Leu18-Thr332
检索号 P14778
分子量 62.9 kDa
表观分子量 80-105 kDa
标签 C-Fc
生物活性 Testing in progress

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Interleukin 1 Receptor, type I (IL-1R1) is an Interleukin Receptor that belongs to the Interleukin-1 Receptor family. IL-1R1 is an 80 kDa transmembrane Protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. This gene along with IL1R2, IL1RL2, and IL1RL1 form a Cytokine Receptor gene cluster in a region mapped to chromosome 2q12. IL-1R1 is an important mediator involved in many Cytokine induced immune and inflammatory responses. It binds to Interleukin-1 associates with the corecptor IL1RAP to form the high affinity Interleukin-1 Receptor complex which mediates Interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. The signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the Receptor/ coReceptor subunits. It also binds Ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. An IL1 Receptor accessory Protein that can heterodimerize with the Type I Receptor in the presence of IL1α or IL1β but not IL1ra, was identified. Recombinant IL1 soluble Receptor Type I is a potent antagonist of IL1 action.
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