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当前位置:首页 >> 产品中心 >> 辅助试剂 >> 细胞因子 >> Human

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  • Procell-IL-23R (C-Fc), Human, Recombinant

IL-23R (C-Fc), Human, Recombinant

货号:PCK153

价格:¥1280¥2980¥17480¥25680

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Interleukin-23 Receptor; IL23R; IL-23 Receptor; IL-23R
物种 Human
表达宿主 Human Cells
序列信息 Gly24-Asp353
检索号 Q5VWK5
分子量 65.0 kDa
表观分子量 90-120 kDa
标签 C-Fc
生物活性 Measured by its ability to binding recombinant human IL-23A&IL12B used funtional ELISA. The ED50 for this effect is less than 5 ug/ ml.

产品特性

纯度 >90% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Interleukin 23 Receptor (IL23R) is a type I Cytokine Receptor for IL23. IL23 Receptor complex is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several Cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the IL23R gene were reported to be associated with susceptibility to inflammatory diseases and autoimmune diseases such as psoriasis, multiple sclerosis, Graves' s ophtalmopathy and inflammatory bowel diseases. The IL23R is known to be critically involved in the carcinogenesis of different malignant tumor.
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