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产品概述
产品信息
| 别名 | Insulin-Like Growth Factor II; IGF-II; Somatomedin-A; IGF2; PP1446 |
| 物种 | Human |
| 表达宿主 | E.coli |
| 序列信息 | Ala25-Glu91 |
| 检索号 | P01344 |
| 分子量 | 8.9 kDa |
| 表观分子量 | 15 kDa |
| 生物活性 | Measured in a serum-free cell proliferation assay using MCF‑7 human breast cancer cellsThe ED50 for this effect is less than 20 ng/ ml. |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 5mM Hac, pH ~3.0. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
Insulin-Like Growth Factor II (IGF2) belongs to the Insulin family of polypeptide Growth Factors that is involved in development and growth. Members of this family are structurally homologous to proInsulin, and share higher sequence identity. IGF2 is expressed only from the paternally inherited allele and believed to be secreted by the liver and to circulate in the blood. IGF2 possess growth-promoting activity and can stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGF2 is influenced by placental lactogen and may play a role in fetal development.
