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当前位置:首页 >> 产品中心 >> 辅助试剂 >> 细胞因子 >> Human

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  • Procell-IL-11/ AGIF, Human, Recombinant

IL-11/ AGIF, Human, Recombinant

货号:PCK170

价格:¥1780¥4980¥13880¥19980

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Interleukin-11; IL-11; Adipogenesis Inhibitory Factor; AGIF; Oprelvekin; IL11
物种 Human
表达宿主 Yeast
序列信息 Gly23-Leu199
检索号 P20809
分子量 19 kDa
表观分子量 19 kDa
生物活性 Measured in a cell proliferation assay using murine 7TD1 cells.The ED50 for this effect is typically 0.2 ng/ mL

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB, 2% Glycine, pH 7.2.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Interleukin 11 (IL-11) is a member of a family of human Growth Factors that includes human growth hormone, granulocyte colony-stimulating factor, and other Growth Factors. IL-11 is a thrombopoietic Growth Factor that directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production. It also promotes the proliferation of hepatocytes in response to liver damage. Binding to its Receptor formed by IL6ST and either IL11RA1 or IL11RA2, It activates a signaling cascade that promotes cell proliferation. The signaling leads to the activation of intracellular Protein kinases and the phosphorylation of STAT3.
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