全国免费热线:400 650 3656

您身边的细胞培养专家!

忘记密码

个人邮箱:
验证码: captcha

账号激活

个人邮箱:
×
当前位置:首页 >> 产品中心 >> 辅助试剂 >> 细胞因子 >> Human

产品中心Cell Resources

联系我们CONTACT US

  • Procell-IL-35, Human, Recombinant

IL-35, Human, Recombinant

货号:PCK193

价格:¥1280¥2980¥17480¥25680

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Interleukin 35; IL35; hIL35
物种 Human
表达宿主 Human Cells
序列信息 Arg21-Lys229&Arg23-Ser219
检索号 Q14213&P29459
分子量 73.9 kDa
表观分子量 90-120 kDa
标签 C-6His
生物活性 Measured by its ability to bind biotinylated human IL6RB-Fch in a functional ELISA.

产品特性

纯度 >80% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融 Please refer to it for detailed information.

背景介绍

The novel Ebi3-IL-12alpha heterodimeric Cytokine has been designated Interleukin-35 (IL-35), is a member IL12 family Cytokine produced by regulatory T cells (Treg), but not by resting or activated effector T cells (Teff). IL-35 is a heterodimeric Protein composed of IL-12α (P35) and IL-27β chains, which are encoded by two separate genes called IL12A and EBI3 (Epstein-Barr-virus-induced gene 3) respectively. Ectopic expression of IL-35 confers regulatory activity on naive T cells, whereas recombinant IL-35 suppresses T-cell proliferation. It identify IL-35 as a novel inhibitory Cytokine that may be specifically produced by T (reg) cells and is required for maximal suppressive activity. IL-35 has biological activity and able to expand CD4+CD25+ Treg cells, suppress the proliferation of CD4+CD25- effector cells and inhibit Th17 cell polarization. IL-35 has been shown to be constitutively expressed by regulatory T (Treg) cells CD4 (+)CD25 (+)Foxp3 (+) and suggested to contribute to their suppressive activity. IL-35 is a crucial mediator which provokes CD4+CD25+ T cell proliferation and IL-10 generation, another well-known anti-inflammatory Cytokine, along with TGFbeta Cytokine. IL-35 is a Cytokine can downregulate Th17 cell development and inhibit autoimmune inflammation. It inhibited the differentiation of Th17 cells in vitro. In vivo, IL-35 effectively attenuated established collagen-induced arthritis in mice, with concomitant suppression of IL-17 production but enhanced IFN-gamma synthesis. Thus, IL-35 is a novel anti-inflammatory Cytokine suppressing the immune response through the expansion of regulatory T cells and suppression of Th17 cell development.
朱莎莉

朱莎莉

【 湖北、河南 】

刘本佳

刘本佳

【 江苏、上海、安徽 】

章臣雄

章臣雄

【 广东、广西、贵州、云南 】

閤春喜

閤春喜

【 四川、重庆、陕西、甘肃、西藏 】

石文平

石文平

【 北京、黑龙江、吉林、辽宁 】

任施博

任施博

【 江西、福建、新疆、海南 】

李荣枫

李荣枫

【 天津、河北、内蒙古、山西 】

陈雨兰

陈雨兰

【 湖南、山东、宁夏、青海 】

田庆如

田庆如

【浙江】

黄龄

黄玲

【 华中、华西 】

李欢欢

李欢欢

【 华东、华南 】

尤会杰

尤会杰

【 华北、西南、西北 】