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  • Procell-IL-4Rα/ CD124 (C-Fc), Human, Recombinant

IL-4Rα/ CD124 (C-Fc), Human, Recombinant

货号:PCK200

价格:¥1280¥2980¥17480¥25680

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Interleukin-4 Receptor subunit alpha; IL-4 Receptor subunit alpha; IL-4R subunit alpha; IL-4R-alpha; IL-4RA; CD124; IL-4-binding Protein; IL4-BP; IL4R; IL4RA
物种 Human
表达宿主 Human Cells
序列信息 Met26-Gln231
检索号 P24394
分子量 50.2 kDa
表观分子量 60-70 kDa
标签 C-Fc
生物活性 Measured by its ability to inhibit IL-4-dependent proliferation of TF‑1 human erythroleukemic cells.The ED50 for this effect is less than 20 ng/ ml.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Interleukin 4 Receptor alpha (IL4-Ra) is a widely expressed 140 kDa transmembrane glyco Protein in the class I Cytokine Receptor family. Mature human IL4-Ra consists of a 207 amino acid (aa) extracellular domain (ECD) that contains a Cytokine binding region and one fibronectin type III domain, a 24 aa transmembrane segment, and a 569 aa cytoplasmic domain that contains one Box 1 Motif and one ITIM Motif. IL4-Ra plays an important role in Th2-biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. Soluble forms of IL4-Ra, generated by alternate splicing or proteolysis, retain Ligand binding properties and inhibit IL-4 bioactivity. IL4-Ra is a component of two distinct Receptor complexes and shows species selectivity between human and mouse. It can associate with the common gamma chain (γc) to form the IL-4 responsive type I Receptor in which γc increases the affinity for IL-4 and enables signaling. It can alternatively associate with IL13-Ra1 to form the type II Receptor which is responsive to both IL-4 and IL-13. The use of shared Receptor components contributes to the overlapping biological effects of IL-4 and IL-13 as well as other Cytokines that utilize γc.
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