全国免费热线:400 650 3656

您身边的细胞培养专家!

忘记密码

个人邮箱:
验证码: captcha

账号激活

个人邮箱:
×
当前位置:首页 >> 产品中心 >> 辅助试剂 >> 细胞因子 >> Human

产品中心Cell Resources

联系我们CONTACT US

  • Procell-RSPO1 (C-6His), Human, Recombinant

RSPO1 (C-6His), Human, Recombinant

货号:PCK214

价格:¥1380¥3680¥17480¥25680

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 RSPO1; R-spondin1; RP11-566C13.1; CRISTIN3; FLJ40906; RSPO Rspo1; R-spondin; Rspondin; RP23-325M14.2; Roof plate-specific spondin-1
物种 Human
表达宿主 Human Cells
序列信息 Arg31-Ala263
检索号 Q2MKA7
分子量 26.6 kDa
表观分子量 40 kDa
标签 C-6His
生物活性 Measured by its ability to bind Mouse CD36 in functional ELISA. The ED50 for this effect is less than 100 ng/ ml.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

RSPO1 is a secreted Protein,containing 2 FU (furin-like) repeats and 1 TSP type-1 domain and belonging to the R-spondin family. RSPO1 is required for the early development of gonads, regardless of sex. It has been found in mice only eleven days after fertilization. To induce cell proliferation, it acts synergistically with WNT4. They help stabilize β catenin, which activates downstream targets. RSPO1 is necessary in female sex development. It augments the WNT/ β catenin pathway to oppose male sex development. In critical gonadal stages, between six and nine weeks after fertilization, the ovaries upregulate it while the testes downregulate it. RSPO1 can potentially aid in the treatment of mucositis, which is characterized by inflammation of the oral cavity. This unfortunate condition often accompanies chemotherapy and radiation in cancer patients with head and neck tumors.
朱莎莉

朱莎莉

【 湖北、河南 】

刘本佳

刘本佳

【 江苏、上海、安徽 】

章臣雄

章臣雄

【 广东、广西、贵州、云南 】

閤春喜

閤春喜

【 四川、重庆、陕西、甘肃、西藏 】

石文平

石文平

【 北京、黑龙江、吉林、辽宁 】

任施博

任施博

【 江西、福建、新疆、海南 】

李荣枫

李荣枫

【 天津、河北、内蒙古、山西 】

陈雨兰

陈雨兰

【 湖南、山东、宁夏、青海 】

田庆如

田庆如

【浙江】

黄龄

黄玲

【 山东、湖南、四川、陕西、甘肃、重庆、西藏、浙江 】

李欢欢

李欢欢

【 江苏、安徽、上海、河北、山西、天津、内蒙古 】

周璇

周璇

【 广东、广西、贵州、云南、福建、海南、江西、新疆、宁夏、青海 】

卢丽丽

卢丽丽

【 湖北、河南、北京、辽宁、吉林、黑龙江 】