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当前位置:首页 >> 产品中心 >> 辅助试剂 >> 细胞因子 >> Mouse

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  • Procell-MCP-1/ CCL2, Mouse, Recombinant

MCP-1/ CCL2, Mouse, Recombinant

货号:PCK227

价格:¥1780¥4980¥18980¥27980

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 C-C Motif Chemokine 2; Monocyte chemoattractant Protein 1; Monocyte chemotactic Protein 1; MCP-1; Platelet-Derived Growth Factor-inducible Protein JE; Small-inducible Cytokine A2; Ccl2; Je; Mcp1; Scya2
物种 Mouse
表达宿主 E.coli
序列信息 Gln24-Arg96
检索号 P10148
分子量 8.5 kDa
表观分子量 12 kDa
生物活性 Testing in progress

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

C-C Motif Chemokine 2 (CCL2) is a member of the C-C or β Chemokine family. Mouse CCL2 shares 82% amino acid (aa) identity with rat CCL2 over the entire sequence, and 58%, 56%, 55%, 53% and 53% aa identity with human, equine, porcine, bovine and canine CCL2, respectively. Fibroblasts, glioma cells, smooth muscle cells, endothelial cells, lymphocytes and mononuclear phagocytes can produce CCL2 either constitutively or upon mitogenic stimulation, but monocytes and macrophages appear to be the major source. In addition to its chemotactic activity, CCL2 induces enzyme and Cytokine release by monocytes, NK cells and lymphocytes, and histamine release by basophils that express its Receptor, CCR2. Additionally, it promotes Th2 polarization in CD4+ T cells. CCL2-mediated recruitment of monocytes to sites of inflammation is proposed to play a role in the pathology of atherosclerosis, multiple sclerosis and allergic asthma.
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