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产品概述
产品信息
| 别名 | C-C Motif Chemokine 21a; 6Ckine; Beta-Chemokine Exodus-2; Small-Inducible Cytokine A21a; Thymus-Derived Chemotactic Agent 4; TCA4; Ccl21a; Scya21; Scya21a |
| 物种 | Mouse |
| 表达宿主 | E.coli |
| 序列信息 | Ser24-Gly133 |
| 检索号 | P84444 |
| 分子量 | 12.0 kDa |
| 表观分子量 | 16 kDa |
| 生物活性 | Testing in progress |
产品特性
| 纯度 | >95% as determined by reducing SDS-PAGE. |
| 内毒素 | < 1.0 EU per µg as determined by LAL test. |
| 保存 | Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| 运输 | The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| 制剂 | Lyophilized from a 0.2 μm filtered solution of 20mM PB，150mM NaCl,pH7.4. |
| 复融 | Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
背景介绍
C-C Motif Chemokine 21a (CCL21a) is a small secreted Cytokine that belongs to the intercrine beta (CC Chemokine) family. Mouse CCL21 cDNA encodes a 133 amino acid residue Protein with a 23 residue signal peptide that is cleaved to generate the 110 residue mature Protein. Mouse CCL21 has three forms while CCL21a has Ser-65. CCL21 elicits its effects by binding to a cell surface Chemokine Receptor known as CCR7 and CXCR3. Mouse CCL21 inhibits hemopoiesis and stimulates chemotaxis. It has chemotactic function in vitro for thymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Mouse CCL21 shows preferential activity towards naive T-cells and may play a role in mediating homing of lymphocytes to secondary lymphoid organs.
