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产品概述
名称 | 4T1(小鼠乳腺癌细胞) (STR鉴定正确) |
别称 | 4T1-A |
种属 | 小鼠 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
生长培养基 | RPMI-1640+10% FBS+1% P/S |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养条件 | 气相:空气,95%;CO2,5% 温度:37℃ |
推荐传代比例 | 1:3-1:4 |
推荐换液频率 | 2~3次/周 |
背景描述 | 4T1细胞是从410.4瘤株中未经诱变筛得的6-硫鸟嘌噙抗性细胞株。当4T1细胞注射到BALB/c小鼠中时,4T1细胞会自发产生高转移肿瘤,可转移到肺、肝、淋巴结和大脑,同时在注射部位形成始发灶,诱导转移时不需要摘除始发灶。4T1细胞在BALB/c小鼠中的生长与转移特性与人体中的乳腺癌十分相近,这种肿瘤是人Ⅵ期乳腺癌的动物模型。4T1细胞诱导的肿瘤在手术后及未手术情况下转移的动力学相近,可以用作手术后及未手术模型。4T1细胞诱导的肿瘤模型跟其他肿瘤模型相比,由于4T1细胞的抗6-硫鸟嘌噙特性,微小的转移细胞团(少到仅仅1个)也可以在许多远端器官中检测到,没必要数淋巴结或称重器官。 |
组织来源 | 乳腺组织 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 乳腺癌细胞 |
生物安全等级 | 1 |
致瘤性 | Yes, forms tumors and metastasizes in BALB/c mice. |
保藏机构 | ATCC; CRL-2539 |
STR鉴定
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STR位点信息
18-3 18,19 6-7 12 5-5 14 X-1 24,25 1-2 17 7-1 25.2 8-1 13 1-1 16 19-2 13 15-3 22.3 12-1 16,17 6-4 18 4-2 21.3 3-2 14,15 2-1 16,17 13-1 16.2
11-2 18,19 17-2 15 -
STR鉴定图
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参考文献
-
Dynamically Reconstructed Collagen Fibers for Transmitting Mechanical Signals to Assist Macrophages Tracing Breast Cancer Cells(2022/12/23)
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DOI:10.1016/j.actbio.2020.02.013
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