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产品概述
名称 | A-375 (人恶性黑色素瘤细胞) (STR鉴定正确) |
别称 | A 375; A375; A375-MEL; A375-mel; A375mel |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
生长培养基 | DMEM+10% FBS+1% P/S |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养条件 | 气相:空气,95%;CO2,5% 温度:37℃ |
推荐传代比例 | 1:3-1:4 |
推荐换液频率 | 2~3次/周 |
背景描述 | A-375细胞源自一位54岁女性,是由D·J·Giard等人建立的一系列细胞株中的一株。A-375细胞在抗胸腺细胞球蛋白、血清处理的NIH瑞士小鼠中形成类似于恶性黑素瘤的快速增长的皮下肿瘤;A-375在普通成纤维细胞和琼脂上形成克隆。 |
年龄(性别) | 女;54岁 |
组织来源 | 皮肤;恶性黑色素瘤 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 黑色素瘤细胞 |
生物安全等级 | 1 |
倍增时间 | ~24-32 hours |
致瘤性 | Yes, in immunosuppressed mice. |
保藏机构 | ATCC; CRL-1619 ATCC; CRL-7904BCRC; 60039 BCRJ; 0278 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11,12 D2S1338 16,24 D3S1358 15,17 D5S818 12 D7S820 9 D8S1179 11,14 D13S317 11,14 D16S539 9 D18S51 12,17 D19S433 13,14.2 D21S11 29,30 FGA 23 PentaD 9,15 PentaE 10,12 TH01 8 TPOX 8,10 vWA 16,17 D6S1043 11,14 D12S391 18,21 D2S441 11 -
STR鉴定图
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参考文献
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An enhanced cascade-based deep forest model for drug combination prediction(2022/03/10)
作者:Weiping Lin, Lianlian Wu, Yixin Zhang
期刊:Briefings In Bioinformatics
影响因子 :13.994
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Dual Modal Imaging-Guided Drug Delivery System for Combined Chemo-Photothermal Melanoma Therapy(2021/05/18)
作者:Dong Zhang, Weifen Zhang, Xinghan Wu
期刊:International Journal of Nanomedicine
影响因子 :8.000
引用产品:CL-0014
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Development and validation of ferroptosis-related lncRNA signature and immune-related gene signature for predicting the prognosis of cutaneous melanoma patients(2023/03/24)
作者:Kaifen Xiong, Zheng Wang, Hounye Alphonse Houssou
期刊:APOPTOSIS
DOI:10.1007/s10495-023-01831-7
影响因子 :7.200
引用产品:CL-0014
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RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma(2023/06/30)
作者:Yanan Guo, Rong Shen, Keren Yang
期刊:Cell Death Discovery
DOI:10.1038/s41420-023-01500-3
影响因子 :7.000
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Evaluation of the Effect of Fibroblasts on Melanoma Metastasis Using a Biomimetic Co-Culture Model(2023/04/07)
作者:Miaoben Wu, Enxing Yu, Kai Ye
期刊:ACS Biomaterials Science & Engineering
DOI:10.1021/acsbiomaterials.2c01186
影响因子 :5.800
引用产品:CL-0014
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Promotion of Melanoma Cell Proliferation by Cyclic Straining through Regulatory Morphogenesis(2022/10/06)
作者:Siyuan Huang, Zhu Chen, Xiaoqiang Hou
期刊:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 :5.600
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Structures and antitumor activities of ten new and twenty known surfactins from the deep-sea bacterium Limimaricola sp. SCSIO 53532( 2021/12/31)
作者:Wenping Ding, Yanqun Li, Min Chen
期刊: BIOORGANIC CHEMISTRY
DOI:10.1016/j.bioorg.2021.105589
影响因子 :5.100
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Identification and characterization of two novel non-coding Tyrosinase (TYR) gene variants leading to Oculocutaneous albinism type 1(2022/04/10)
作者:Chaoyi Li, Qian Chen, Junjiao Wu
期刊:JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子 :4.800
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LRRK2 correlates with macrophage infiltration in pan-cancer( 2021/12/18)
作者:Jing Yan, Wenhui Zhao, Wei Yu
期刊:Genomics
DOI:10.1016/j.ygeno.2021.11.037
影响因子 :4.400
引用产品:CL-0014
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Acetone Extract of Cornus officinalis Leaves Exerts Anti-Melanoma Effects via Inhibiting STAT3 Signaling(2021/05/28)
作者:Ruiqi Xu, Mengnan Zeng, Yuanyuan Wu
期刊:OncoTargets and Therapy
影响因子 :4.345
引用产品:CL-0014
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A Machine Learning Method for Drug Combination Prediction(2020/08/25)
作者:Jiang Li, Xinyu Tong, Lida Zhu
期刊:Frontiers in Genetics
影响因子 :3.700
引用产品:CL-0014
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CREB1 regulates KPNA2 by inhibiting mir-495-3p transcription to control melanoma progression(2022/12/15)
作者:Xuerui Geng, Xiujuan Qiu, Jun Gao
期刊:BMC Molecular and Cell Biology
DOI:10.1186/s12860-022-00446-1
影响因子 :2.800
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LSM2 is associated with a poor prognosis and promotes cell proliferation, migration, and invasion in skin cutaneous melanoma(2023/06/13)
作者:Xiaofang Sun, Jianping Zhang, Jiayuan Hu
期刊:BMC Medical Genomics
DOI:10.1186/s12920-023-01564-1
影响因子 :2.700
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Extraction and Separation of Sinapine from Rapeseed Cake and the Mode of Action of Melanin Production Inhibition(2021/1/5)
作者:Z. T. Yang, D. X. Lu, E.-K. Hong
期刊:Molecular Biology
影响因子 :1.200
引用产品:CL-0014
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Human EVI2B acts as a Janus-faced oncogene/antioncogene by differently affecting as per cancer type neoplastic cells growth and immune infiltration:(2023/03/23)
作者:Fangyingnan Zhang, Xinning Wang, Xiaoqi Zhang
期刊:Oncologie
DOI:10.1515/oncologie-2022-1002
影响因子 :0.900
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Naringin suppresses the metabolism of A375 cells by inhibiting the phosphorylation of c-Src(2015/10/17)
作者:Bingyu Guo, Yu Zhang, Qiang Hui
期刊:Tumor Biology
影响因子 :0.000