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产品概述
| 名称 | BxPC-3 (人原位胰腺腺癌细胞) (STR鉴定正确) |
| 别称 | BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3; Biopsy xenograft of Pancreatic Carcinoma line-3 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | BxPC-3细胞不表达囊肿性纤维化跨膜电导调节子(CFTR)，CFTR阳性的细胞株是Capan-1。 |
| 年龄（性别） | 女性；61岁 |
| 组织来源 | 胰腺；腺癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 胰腺癌细胞 |
| 生物安全等级 | BSL-1 |
| 倍增时间 | ~48-60 hours |
| 致瘤性 | Yes, Tumors developed within 21 days at 100% frequency (5/5) in nude mice inoculated subcutaneously with 1×10^7 cells. |
| 基因表达情况 | mucin; pancreas cancer specific antigen (pancreas cancer associated antigen); carcinoembryonic antigen (CEA) |
| 保藏机构 | ATCC; CRL-1687 BCRC; 60283 BCRJ; 0056 DSMZ; ACC-760 ECACC; 93120816 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 13 D2S1338 17,19 D3S1358 14,16 D5S818 11 D7S820 10,13 D8S1179 13 D13S317 11 D16S539 9,11 D18S51 12 D19S433 13,16.2 D21S11 29 FGA 20,21 PentaD 14 PentaE 12,14 TH01 9 TPOX 8 vWA 14,18 D6S1043 12 D12S391 19.3,20 D2S441 12,14 -
STR鉴定图
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参考文献
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Biomimetic camouflaged nanoparticle-based folfirinox platform for optimizing clinical pancreatic cancer treatment(2022/12/21)
作者：Qian Wang, Zihua Wang, Zhangfu Li
期刊：Nano Today
DOI：10.1016/j.nantod.2022.101733
影响因子 ：17.400
引用产品：CL-0042
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ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway(2022/04/07)
作者：Ma Zuyi, Li Zhenchong, Wang Shujie
期刊：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI：10.1186/s13046-022-02310-8
影响因子 ：11.300
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Albumin binding revitalizes NQO1 bioactivatable drugs as novel therapeutics for pancreatic cancer(2022/08/04)
作者：Lei Dou, Huiqin Liu, Kaixin Wang
期刊：JOURNAL OF CONTROLLED RELEASE
DOI：10.1016/j.jconrel.2022.07.033
影响因子 ：10.800
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Extracellular matrix modulating enzyme functionalized biomimetic Au nanoplatform-mediated enhanced tumor penetration and synergistic antitumor therapy for pancreatic cancer(2022/12/10)
作者：Xiaoyan Yang, Jinguo Zhang, Qiaomei Zhou
期刊：JOURNAL OF NANOBIOTECHNOLOGY
DOI：10.1186/s12951-022-01738-6
影响因子 ：10.200
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Radionuclide labeled nanocarrier for imaging guided combined radionuclide, sonodynamic, and photothermal therapy of pancreatic tumours(2023/03/30)
作者：Jie An, Xinyi He, Huizhu Ma
期刊：JOURNAL OF COLLOID AND INTERFACE SCIENCE
DOI：10.1016/j.jcis.2023.03.111
影响因子 ：9.900
引用产品：CL-0042
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SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway via the hnRNPK-YAP1 axis(2021/07/24)
作者：Dianyun Ren, Yan Sun, Dan Zhang
期刊：Cancer Letters
DOI：10.1016/j.canlet.2021.07.035
影响因子 ：9.700
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pH-Sensitive Biomimetic Nanosystem Based on Large-Pore Mesoporous Silica Nanoparticles with High Hyaluronidase Loading for Tumor Deep Penetration(2023/08/05)
作者：Xiaojie Song, Chunling Li, Nan Qiu
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.500
引用产品：CL-0042
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METTL3 enhances pancreatic ductal adenocarcinoma progression and gemcitabine resistance through modifying DDX23 mRNA N6 adenosine methylation(2023/03/28)
作者：Chengjie Lin, Ting Li, Yan Wang
期刊：Cell Death & Disease
DOI：10.1038/s41419-023-05715-1
影响因子 ：9.000
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GSK2126458 has the potential to inhibit the proliferation of pancreatic cancer uncovered by bioinformatics analysis and pharmacological experiments(2021/08/30)
作者：Yueqin Feng, Yuguan Jiang, Fengjin Hao
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-021-03050-7
影响因子 ：7.400
引用产品：CL-0042
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Molecular mechanisms of pancreatic cancer liver metastasis: the role of PAK2(2024/01/26)
作者：Hao Yang, Zhongyi Li, Shiqi Zhu
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2024.1347683
影响因子 ：7.300
引用产品：CL-0042
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Pan-cancer analysis of Krüppel-like factor 3 and its carcinogenesis in pancreatic cancer(2023/08/03)
作者：Jinfeng Zhu, Hong Teng, Xiaojian Zhu
期刊：Frontiers in Immunology
DOI：10.3389/fimmu.2023.1167018
影响因子 ：7.300
引用产品：CL-0042
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Crosstalk of ferroptosis regulators and tumor immunity in pancreatic adenocarcinoma: novel perspective to mRNA vaccines and personalized immunotherapy(2023/06/27)
作者：Yanlong Shi, Yizhu Wang, Hui Dong
期刊：APOPTOSIS
DOI：10.1007/s10495-023-01868-8
影响因子 ：7.200
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5′-tRF-19-Q1Q89PJZ Suppresses the Proliferation and Metastasis of Pancreatic Cancer Cells via Regulating Hexokinase 1-Mediated Glycolysis(2023/10/12)
作者：Wenpeng Cao, Zhirui Zeng, Shan Lei
期刊：Biomolecules
影响因子 ：5.500
引用产品：CL-0042
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RBM15 Promates the Proliferation, Migration and Invasion of Pancreatic Cancer Cell Lines(2023/02/08)
作者：Hui Dong, Haidong Zhang, Xinyu Mao
期刊：Cancers
影响因子 ：5.200
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COL12A1 Acts as a Novel Prognosis Biomarker and Activates Cancer-Associated Fibroblasts in Pancreatic Cancer through Bioinformatics and Experimental Validation(2023/02/26)
作者：Yao Song, Lei Wang, Kaidong Wang
期刊：Cancers
影响因子 ：5.200
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Pyroptosis regulators exert crucial functions in prognosis, progression and immune microenvironment of pancreatic adenocarcinoma: a bioinformatic and in vitro research(2022/01/08)
作者：Zhenghai Bai, Fangshi Xu, Xiaodan Feng
期刊：Bioengineered
DOI：10.1080/21655979.2021.2019873
影响因子 ：4.900
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Aberrant expression of PELI1 caused by Jagged1 accelerates the malignant phenotype of pancreatic cancer(2023/08/30)
作者：Wenyang Zhou, Yuying Hu, Baosheng Wang
期刊：CELLULAR SIGNALLING
DOI：10.1016/j.cellsig.2023.110877
影响因子 ：4.800
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Identification and characterization of interferon-γ signaling-based personalized heterogeneity and therapeutic strategies in patients with pancreatic cancer(2023/10/24)
作者：Xu Chen, Qihang Yuan, Hewen Guan
期刊：Frontiers in Oncology
影响因子 ：4.700
引用产品：CL-0042
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Tartary buckwheat root polysaccharides ameliorate non-alcoholic fatty liver disease via the IL6-SOCS3-SREBP1c pathway(2023/08/19)
作者：Litao Zhang, Shuo Wang, Yimin Li
期刊：FOOD AND CHEMICAL TOXICOLOGY
影响因子 ：4.300
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GPR120 promotes metastasis but inhibits tumor growth in pancreatic ductal adenocarcinoma(2022/06/05)
作者：Xiaoyuan Sun, Huijun Chu, Ke Lei
期刊：PANCREATOLOGY
影响因子 ：3.977
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Lactobacillus casei combined with Lactobacillus reuteri alleviate pancreatic cancer by inhibiting TLR4 to promote macrophage M1 polarization and regulate gut microbial homeostasis(2023/10/30)
作者：Zemin Zhu, Bo Yi, Zikai Tang
期刊：BMC CANCER
DOI：10.1186/s12885-023-11557-z
影响因子 ：3.800
引用产品：CL-0042
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IFN-γ affects pancreatic cancer properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway(2022/01/17)
作者：X-Y Shi, X-L Zhang, Q-Y Shi
期刊：Clinical & Translational Oncology
DOI：10.1007/s12094-021-02748-w
影响因子 ：3.400
引用产品：CL-0042
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Long non-coding RNA OIP5-AS1 promotes pancreatic cancer cell growth through sponging miR-342-3p via AKT/ERK signaling pathway(2020/3/10)
作者：Xiangpeng Meng, Jia Ma, Baosheng Wang
期刊：Journal Of Physiology And Biochemistry
DOI：10.1007/s13105-020-00734-4
影响因子 ：3.400
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Comprehensive pan-cancer analysis of role of GPRASP1, associated with clinical outcomes, immune microenvironment, and immunotherapeutic efficiency in pancreatic cancer(2023/02/12)
作者：Jiaxing Du, Yongsheng Chen, Genglong Liu
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：2.800
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GPX3 represses pancreatic cancer cell proliferation, migration and invasion, and improves their chemo‑sensitivity by regulating the JNK/c‑Jun signaling pathway(2024/01/29)
作者：Ye Ma, Lixing Zhang, Xin Gao
期刊：Experimental and Therapeutic Medicine
影响因子 ：2.700
引用产品：CL-0042
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Synthesis of Copper and Cobalt complexes with a Hydrothermal Method and Their Applications in Antibiological Activity(2023/12/01)
作者：Qiongli Luo, Lei Wang, Shuangyan Wu
期刊：ChemistrySelect
影响因子 ：2.100
引用产品：CL-0042
