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产品概述
| 名称 | BxPC-3 (人原位胰腺腺癌细胞) (STR鉴定正确) |
| 别称 | BxPc-3; BXPC-3; Bx-PC3; BXPC3; BxPC3; BxPc3; Biopsy xenograft of Pancreatic Carcinoma line-3 |
| 背景描述 | BxPC-3细胞不表达囊肿性纤维化跨膜电导调节子(CFTR)，CFTR阳性的细胞株是Capan-1。 |
| 种属 | 人 |
| 年龄（性别） | 女；61岁 |
| 组织来源 | 胰腺；腺癌 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 胰腺癌细胞 |
| 生物安全等级 | 1 |
| 生长培养基 | RPMI-1640＋10% FBS＋1% P/S |
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2~3次/周 |
| 倍增时间 | ~48-60 hours |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
| 致瘤性 | Yes, Tumors developed within 21 days at 100% frequency (5/5) in nude mice inoculated subcutaneously with 1×10^7 cells. |
| 基因表达情况 | mucin; pancreas cancer specific antigen (pancreas cancer associated antigen); carcinoembryonic antigen (CEA) |
| 保藏机构 | ATCC; CRL-1687 BCRC; 60283 BCRJ; 0056 DSMZ; ACC-760 ECACC; 93120816 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 13 D2S1338 17,19 D3S1358 14,16 D5S818 11 D7S820 10,13 D8S1179 13 D13S317 11 D16S539 9,11 D18S51 12 D19S433 13,16.2 D21S11 29 FGA 20,21 PentaD 14 PentaE 12,14 TH01 9 TPOX 8 vWA 14,18 D6S1043 12 D12S391 19.3,20 D2S441 12,14 -
STR鉴定图
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参考文献
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ZMAT1 acts as a tumor suppressor in pancreatic ductal adenocarcinoma by inducing SIRT3/p53 signaling pathway(2022/04/07)
作者：Ma Zuyi, Li Zhenchong, Wang Shujie
期刊：JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
DOI：10.1186/s13046-022-02310-8
影响因子 ：12.6580
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Albumin binding revitalizes NQO1 bioactivatable drugs as novel therapeutics for pancreatic cancer(2022/08/04)
作者：Lei Dou, Huiqin Liu, Kaixin Wang
期刊：JOURNAL OF CONTROLLED RELEASE
DOI：10.1016/j.jconrel.2022.07.033
影响因子 ：11.4670
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SGLT2 promotes pancreatic cancer progression by activating the Hippo signaling pathway via the hnRNPK-YAP1 axis(2021/07/24)
作者：Dianyun Ren, Yan Sun, Dan Zhang
期刊：Cancer Letters
DOI：10.1016/j.canlet.2021.07.035
影响因子 ：9.756
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GSK2126458 has the potential to inhibit the proliferation of pancreatic cancer uncovered by bioinformatics analysis and pharmacological experiments(2021/08/30)
作者：Yueqin Feng, Yuguan Jiang, Fengjin Hao
期刊：Journal of Translational Medicine
DOI：10.1186/s12967-021-03050-7
影响因子 ：8.440
引用产品：CL-0042
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Pyroptosis regulators exert crucial functions in prognosis, progression and immune microenvironment of pancreatic adenocarcinoma: a bioinformatic and in vitro research(2022/01/08)
作者：Zhenghai Bai, Fangshi Xu, Xiaodan Feng
期刊：Bioengineered
DOI：10.1080/21655979.2021.2019873
影响因子 ：6.8320
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Upstream stimulatory factor 2 inhibits erastin-induced ferroptosis in pancreatic cancer through transcriptional regulation of pyruvate kinase M2(2022/09/20)
作者：Meijie Chen, Xuena Li, Bulin Du
期刊：BIOCHEMICAL PHARMACOLOGY
影响因子 ：6.1000
引用产品：CL-0027 CL-0042 CL-0059 CL-0184 CL-0448A CL-0627 CM-0059 CM-0448A
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Long non-coding RNA OIP5-AS1 promotes pancreatic cancer cell growth through sponging miR-342-3p via AKT/ERK signaling pathway(2020/3/10)
作者：Xiangpeng Meng, Jia Ma, Baosheng Wang
期刊：Journal Of Physiology And Biochemistry
DOI：10.1007/s13105-020-00734-4
影响因子 ：5.0800
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CMTM3 Overexpression Predicts Poor Survival and Promotes Proliferation and Migration in Pancreatic Cancer(2021/08/03)
作者：Zixuan Zhou, Zuyi Ma, Zhenchong Li
期刊：Journal of Cancer
影响因子 ：4.478
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IFN-γ affects pancreatic cancer properties by MACC1-AS1/MACC1 axis via AKT/mTOR signaling pathway(2022/01/17)
作者：X-Y Shi, X-L Zhang, Q-Y Shi
期刊：Clinical & Translational Oncology
DOI：10.1007/s12094-021-02748-w
影响因子 ：3.3400
引用产品：CL-0042
