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产品概述
| 名称 | C-33 A (人子宫颈癌细胞) (STR鉴定正确) |
| 别称 | C33A; C33a; C33-A; C-33-A; C-33A; C33 |
| 背景描述 | C-33 A细胞是由N·Auersperg从宫颈癌切片中建立的一系列细胞株中的一株。C-33 A细胞一开始就表现出亚二倍体核型及上皮细胞形态，C-33 A细胞经连续传代可以观察到核型不稳定。C-33 A细胞存在成视网膜细胞瘤蛋白(pRB)，但大小不正常；C-33 A细胞p53表达上调，且有一个273位密码子的点突变导致Arg→Cys的替换。 |
| 种属 | 人 |
| 年龄（性别） | 女；66岁 |
| 组织来源 | 宫颈癌 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 宫颈癌细胞 |
| 生物安全等级 | 1 |
| 生长培养基 | MEM（含NEAA）＋10% FBS＋1% P/S |
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2~3次/周 |
| 倍增时间 | ~32-48 hours |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
| 保藏机构 | ATCC; HTB-31 ATCC; CRM-HTB-31 BCRC; 60554 BCRJ; 0348 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12 D2S1338 23,25 D3S1358 16 D5S818 11,12 D7S820 10 D8S1179 10,14 D13S317 13 D16S539 13,14 D18S51 15,18 D19S433 11,13,14 D21S11 29,30,31 FGA 21,26 PentaD 10 PentaE 6,8 TH01 7,8 TPOX 9 vWA 18,20 D6S1043 9,12 D12S391 18,27,28 D2S441 10,14 -
STR鉴定图
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参考文献
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Acetylation-stabilized chloride intracellular channel 1 exerts a tumor-promoting effect on cervical cancer cells by activating NF-κB(2021/01/19)
作者：Wanyue Wang, Xin Li, Ye Xu
期刊：Cellular Oncology
DOI：10.1007/s13402-020-00582-w
影响因子 ：7.051
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Kinetochore-associated protein 1 promotes the invasion and tumorigenicity of cervical cancer cells via matrix metalloproteinase-2 and matrix metalloproteinase-9(2022/04/07)
作者：Caimei Wang, Yiyuan Wang, Congrong Liu
期刊：Bioengineered
DOI：10.1080/21655979.2022.2061144
影响因子 ：6.8320
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Combined treatment of marizomib and cisplatin modulates cervical cancer growth and invasion and enhances antitumor potential in vitro and in vivo(2022/08/30)
作者：Ziruizhuo Zhang, Songcheng Zhang, Bingjie Lin
期刊：Frontiers in Oncology
影响因子 ：5.7380
引用产品：CL-0045
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Signature of seven cuproptosis-related lncRNAs as a novel biomarker to predict prognosis and therapeutic response in cervical cancer.(2022/09/20)
作者：Xinyu Liu, Lei Zhou, Minghui Gao
期刊：Frontiers in Genetics
影响因子 ：4.7720
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USP21 regulates Hippo signaling to promote radioresistance by deubiquitinating FOXM1 in cervical cancer(2021/11/25)
作者：Zhengliang Li , Xiaojing Liu , Haizhou Yu
期刊：Human Cell
DOI：10.1007/s13577-021-00650-9
影响因子 ：4.3740
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HPV16+‐miRNAs in cervical cancer and the anti‐tumor role played by miR‐5701(2019/09/09)
作者：Nuerbieke Pulati, Zegao Zhang, Aireti Gulimilamu
期刊：Journal of Gene Medicine
DOI：10.1002/jgm.3126
影响因子 ：4.152
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OTX1 promotes tumorigenesis and progression of cervical cancer by regulating the Wnt signaling pathway(2022/09/29)
作者：Limin Zhou, Hongying Li, Dunlan Zhang
期刊：ONCOLOGY REPORTS
影响因子 ：4.1360
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The degradation of Rap1GAP via E6AP-mediated ubiquitin-proteasome pathway is associated with HPV16/18-infection in cervical cancer cells(2021/12/24)
作者：Yinghui Wang, Yihang Xie, Boxuan Sun
期刊：Infectious Agents and Cancer
DOI：10.1186/s13027-021-00409-9
影响因子 ：3.6980
引用产品：CL-0045
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FBXO39 predicts poor prognosis and correlates with tumor progression in cervical squamous cell carcinoma(2022/08/28)
作者：Yanru Yang, Yun Zhao, Guorui Sun
期刊：PATHOLOGY RESEARCH AND PRACTICE
影响因子 ：3.3090
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Inhibition of miR-574-5p suppresses cell growth and metastasis and enhances chemosensitivity by targeting RNA binding protein QKI in cervical cancer cells(2019/11/30)
作者：Rui Tong, Jingru Zhang, Chunyan Wang
期刊：Naunyn-Schmiedebergs Archives of Pharmacology
DOI：10.1007/s00210-019-01772-6
影响因子 ：3.1950
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tRNA‑derived fragment tRF‑Glu49 inhibits cell proliferation, migration and invasion in cervical cancer by targeting FGL1(2022/08/09)
作者：Yang Wang, Wenying Xia, Fangrong Shen
期刊：Oncology Letters
影响因子 ：3.1110
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LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR‐574‐5p(2019/10/6)
作者：Rui Tong, Jingru Zhang, Chunyan Wang
期刊：Clinical And Experimental Pharmacology And Physiology
影响因子 ：2.9630
引用产品：CL-0045
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LncRNA PTCSC3 inhibits the proliferation, invasion and migration of cervical cancer cells via sponging miR‐574‐5p(2019/10/06)
作者：Rui Tong, Jingru Zhang, Chunyan Wang
期刊：Clinical and Experimental Pharmacology and Physiology
影响因子 ：2.963
引用产品：CL-0045
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CLCA2 overexpression suppresses epithelial-to-mesenchymal transition in cervical cancer cells through inactivation of ERK/JNK/p38-MAPK signaling pathways(2022/10/25)
作者：Wenhu Xin, Jian Zhang, Haibin Zhang
期刊：BMC Molecular and Cell Biology
DOI：10.1186/s12860-022-00440-7
影响因子 ：2.8130
