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产品概述
| 名称 | CT26.WT (小鼠结肠癌细胞) (STR鉴定正确) |
| 别称 | CT26WT |
| 种属 | 小鼠 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 成纤维细胞样 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 背景描述 | CT26细胞是以N-亚硝基-N-甲基氨基甲酸酯(NNMU)诱导形成的未分化结肠癌细胞株，它克隆形成的细胞株命名为CT26.WT。用包含编码典型肿瘤相关抗原(TAA)β-半乳糖苷酶(β-gal)的lacZ基因的逆转录病毒载体LXSN稳定转染CT26.WT细胞，得到致死的亚克隆CT26.CL25。即使CT26.CL25细胞表达了典型的TAA-β-半乳糖苷酶，在正常小鼠中CT26.CL25细胞和CT26.WT细胞的生长率与致死率也保持基本一致。CT26.WT细胞与CT26.CL25细胞一起可用作测试免疫治疗程序的模型，并用于研究宿主免疫反应。 |
| 年龄（性别） | 不详 |
| 组织来源 | 器官：结肠；品系：BALB/c；疾病：癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肠癌细胞 |
| 生物安全等级 | BSL-1 |
| 致瘤性 | Yes, in BALB/c mice. Mice inoculated, subcutaneously, developed lethal tumors at 80% frequency with 1×10^3 cells and at 100% with 1×10^4 cells. Pulmonary metastases developed when mice were inoculated, intravenously, with 1×10^4 cells. |
| 抗原表达情况 | H-2d |
| 保藏机构 | ATCC; CRL-2638 BCRC; 60447 |
STR鉴定
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STR位点信息
18-3 19 6-7 12 5-5 14 X-1 25,26 1-2 17,18 7-1 25.2 8-1 13 1-1 14,15 19-2 13 15-3 21.3,22.3 12-1 16,17 6-4 18,20 4-2 21.3 3-2 14 2-1 16,17 13-1 16.2,17.2,18.2
11-2 17 17-2 15,16 -
STR鉴定图
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参考文献
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Generation of whole tumor cell vaccine for on-demand manipulation of immune responses against cancer under near-infrared laser irradiation(2023/07/26)
作者：Jiaqi Meng, Yanlin Lv, Weier Bao
期刊：Nature Communications
DOI：10.1038/s41467-023-40207-y
影响因子 ：16.600
-
Microbubbles-assisted ultrasonication to promote tumor accumulation of therapeutics and modulation of tumor microenvironment for enhanced cancer treatments(2023/06/01)
作者：Ju Huang, Liang Zhang, Jun Zheng
期刊：BIOMATERIALS
DOI：10.1016/j.biomaterials.2023.122181
影响因子 ：14.000
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Nitroreductase-instructed supramolecular assemblies for microbiome regulation to enhance colorectal cancer treatments(2022/11/09)
作者：Jiali Chen, Pai Zhang, Yan Zhao, Jie Zhao, Xiaobo Wu, Ruijia Zhang, Ruitao Cha, Qingxin Yao, Yuan Gao
期刊：Science Advances
影响因子 ：13.600
引用产品：CL-0071 CL-0096 CL-0101 CL-0118 PM150110 PM150210 PM150710
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Drug-loaded microbubble delivery system to enhance PD-L1 blockade immunotherapy with remodeling immune microenvironment(2023/02/09)
作者：Jun Zheng, Ju Huang, Liang Zhang
期刊：Biomaterials Research
DOI：10.1186/s40824-023-00350-5
影响因子 ：11.300
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Original research: Low molecular weight heparin synergistically enhances the efficacy of adoptive and anti-PD-1-based immunotherapy by increasing lymphocyte infiltration in colorectal cancer(2023/08/18)
作者：Yibo Quan, Jie He, Qi Zou
期刊：Journal for ImmunoTherapy of Cancer
影响因子 ：10.900
引用产品：CL-0071
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Suppression of Tumor or Host Intrinsic CMTM6 Drives Antitumor Cytotoxicity in a PD-L1–Independent Manner(2023/02/03)
作者：Yiru Long, Runqiu Chen, Xiaolu Yu
期刊：Cancer Immunology Research
DOI：10.1158/2326-6066.CIR-22-0439
影响因子 ：10.100
引用产品：CL-0005 CL-0007 CL-0019 CL-0071 CL-0105 CL-0129 CL-0140 CL-0196 CL-0246 CL-0319
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Aggregation-Induced Emission Photosensitizer/Bacteria Biohybrids Enhance Cerenkov Radiation-Induced Photodynamic Therapy by Activating Anti-Tumor Immunity for Synergistic Tumor Treatment(2023/06/15)
作者：Ziyang Zhu, Qingyao Liu, Ke Zhu
期刊：Acta Biomaterialia
DOI：10.1016/j.actbio.2023.06.009
影响因子 ：9.700
引用产品：CL-0071
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A hybrid of lactic acid bacteria and metal-organic frameworks potentiates photodynamic immunotherapy for hypoxia-targeted tumor eradication(2022/08/12)
作者：Tianzhong Li, Jinyong Wang, Tongkai Chen
期刊：Science China-Materials
影响因子 ：8.100
-
Smart Nanosystem-Mediated Inhibition of Mitochondrial Respiration for Enhanced Phototherapy-Induced Antitumor Immunity(2023/06/25)
作者：Yifan Zhao, Bai Lv, Guanghe Xue
期刊：International Journal of Nanomedicine
影响因子 ：8.000
-
Dual-inhibition of lactate metabolism and Prussian blue-mediated radicals generation for enhanced chemodynamic therapy and antimetastatic effect(2023/04/18)
作者：Wenting Li, Shikai Liu, Yangyang Zhang
期刊：Nanoscale
影响因子 ：6.700
-
A tungsten nitride-based degradable nanoplatform for dual-modal image-guided combinatorial chemo-photothermal therapy of tumors(2018/12/27)
作者：Cheng Zhang,Shibo Wang,Zhaoxia Chen
期刊：Nanoscale
影响因子 ：6.700
-
Bifunctional liposomes reduce the chemotherapy resistance of doxorubicin induced by reactive oxygen species(2019/08/15)
作者：Lei Xu, Zhicheng Zhang, Yawen Ding
期刊：Biomaterials Science
影响因子 ：6.600
引用产品：CL-0071
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Long noncoding RNA Gm31629 protects against mucosal damage in experimental colitis via YB-1/E2F pathway(2022/03/22)
作者：Xu Feng, Ye Xiao, Jian He
期刊：mBio
DOI：10.1172/jci.insight.150091
影响因子 ：6.500
引用产品：CL-0071
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Tumor-targeting engineered probiotic Escherichia coli Nissle 1917 inhibits colorectal tumorigenesis and modulates gut microbiota homeostasis in mice(2023/04/24)
作者：Haibo Tang, Tuoyu Zhou, Weilin Jin
期刊：Life Sciences
影响因子 ：6.100
引用产品：CL-0071
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CAR-T-Cell Therapy for Solid Tumors Positive for Fibronectin Extra Domain B(2022/09/14)
作者：Zhijie Zhang, Chang Liu, Zhe Yang
期刊：Cells
影响因子 ：6.000
-
Ansofaxine hydrochloride inhibits tumor growth and enhances Anti-TNFR2 in murine colon cancer model(2023/12/14)
作者：Qianyu Jing, Quan Wan, Yujie Nie
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2023.1286061
影响因子 ：5.600
引用产品：CL-0071
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Lycorine Induces autophagy-associated apoptosis by targeting MEK2 and enhances vemurafenib activity in colorectal cancer(2020/01/03)
作者：Man Hu, Zhaomin Yu, Peiyuan Mei
期刊：Aging-US
影响因子 ：5.200
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Gut Microbiome Influences the Efficacy of PD-1 Antibody Immunotherapy on MSS-Type Colorectal Cancer via Metabolic Pathway(2020/4/30)
作者：Xu Xinjian, Lv Ji, Guo Fang
期刊：Frontiers in Microbiology
影响因子 ：5.200
引用产品：CL-0071
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Excessive consumption of mucin by over-colonized Akkermansia muciniphila promotes intestinal barrier damage during malignant intestinal environment(2023/03/02)
作者：Shuang Qu, Yinghui Zheng, Yichun Huang
期刊：Frontiers in Microbiology
DOI：10.3389/fmicb.2023.1111911
影响因子 ：5.200
引用产品：CL-0071
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Self-Assembled Amphiphilic Camptothecin Nanoparticles with Glutathione-Responsive and Tumor-Targeting Ability for Enhanced Colorectal Cancer Therapy(2023/09/21)
作者：XiaoJie Song, Kangli Lan, Yifei Xue
期刊：Advanced Therapeutics
影响因子 ：4.600
引用产品：CL-0071
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Ferulic Acid Induces Autophagy and Apoptosis in Colon Cancer CT26 Cells via the MAPK Pathway(2023/08/11)
作者：Shanbin Chen, Dong Zhao, Chunguang Luan
期刊：MOLECULES
影响因子 ：4.600
引用产品：CL-0071
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Arrangement of Indocyanine Green in a 1.5-Nanometer Channel to Achieve High-Efficiency Imaging of the Intestinal Lymphatic System(2022/12/08)
作者：Xiangyi Kong, Nan Gao, Jianshi Du
期刊：MOLECULES
影响因子 ：4.600
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Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway(2023/12/27)
作者：Fenglin Luo, Yimeng Tang, Lin Zheng
期刊：Pharmaceuticals
影响因子 ：4.600
引用产品：CL-0071
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Danggui Buxue Decoction in the Treatment of Metastatic Colon Cancer: Network Pharmacology Analysis and Experimental Validation(2021/02/24)
作者：Shihan Feng, Bin Zhao, Xue Zhan
期刊：Drug Design Development and Therapy
影响因子 ：4.319
引用产品：CL-0071
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Colorectal cancer-derived extracellular vesicles containing HSP70 enhance macrophage phagocytosis by up-regulating MARCO expression(2023/03/22)
作者：Yu Sun, Wenjun Xiao, Yang Yu
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2023.113565
影响因子 ：3.700
引用产品：CL-0071
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A serum metabolomics study based on LC-MS: Chemosensitization effects of Rauvolfia vomitoria Afzel. combined with 5- fluorouracil on colorectal cancer mice(2022/09/22)
作者：Zhifan Wang, Wenru Kong, Ning Wang
期刊：JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
DOI：10.1016/j.jpba.2022.115074
影响因子 ：3.400
引用产品：CL-0071
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Disulfiram-loaded hollow copper sulfide nanoparticles show anti-tumor effects in preclinical models of colorectal cancer(2022/10/07)
作者：Zeyidan Jiapaer, Lingying Zhang, Wanli Ma
期刊：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI：10.1016/j.bbrc.2022.10.027
影响因子 ：3.100
引用产品：CL-0071
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MiR-26a-5p exerts its influence by targeting EP300, a molecule known for its role in activating the PI3K/AKT/mTOR signaling pathway in CD8+tumor-infiltrating lymphocytes of colorectal cancer(2023/11/30)
作者：Chao Wang, Haonan Lin, Wangqiang Zhao
期刊：CELLULAR AND MOLECULAR BIOLOGY
DOI：10.14715/cmb/2023.69.12.37
影响因子 ：1.600
引用产品：CL-0071
