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产品概述
| 名称 | DU 145 (人前列腺癌细胞) (STR鉴定正确) |
| 别称 | DU-145; Du-145; DU 145; DU_145; Duke University 145 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 生长培养基 | MEM（含NEAA）＋10% FBS＋1% P/S |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2~3次/周 |
| 背景描述 | DU 145细胞是从一位有3年淋巴细胞白血病史的前列腺癌患者的脑部转移病灶损害中建株的。DU 145细胞和从软琼脂中分离到的细胞不具有可检测的激素敏感性，酸性磷酸酶呈弱阳性。对DU 145细胞及原始肿瘤细胞的亚显微结构分析可见微绒毛，微丝及细胞桥粒，有许多线粒体，发育良好高尔基体和异质溶酶体。DU 145细胞不表达前列腺抗体。 |
| 年龄（性别） | 男；69岁 |
| 组织来源 | 前列腺；转移灶；脑癌 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 前列腺癌细胞 |
| 生物安全等级 | 1 |
| 倍增时间 | ~30-40 hours |
| 致瘤性 | Yes, in nude mice; forms adenocarcinoma (grade II) consistent with prostatic primary. |
| 抗原表达情况 | Blood Type O; Rh+ |
| 保藏机构 | ATCC; HTB-81 BCRC; 60348 BCRJ; 0078 DSMZ; ACC-261 |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 10,11 D2S1338 16,17 D3S1358 16 D5S818 10,13 D7S820 7,10,11 D8S1179 13,14 D13S317 12,13,14 D16S539 11,13 D18S51 12 D19S433 13 D21S11 30,33 FGA 21,22 PentaD 9,13 PentaE 12,14 TH01 7 TPOX 11 vWA 17,18,19 D6S1043 11 D12S391 17,18,20,21 D2S441 9,13,14 -
STR鉴定图
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参考文献
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A Liquid–Liquid Phase Separation-Related Index Associate with Biochemical Recurrence and Tumor Immune Environment of Prostate Cancer Patients(2023/03/14)
作者：Qi You, Jiayin Chen, Xiaohui Wu
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.600
-
Ferredoxin 1 is a cuproptosis-key gene responsible for tumor immunity and drug sensitivity: A pan-cancer analysis.(2022/09/21)
作者：Longfei Yang, Yuwei Zhang, Yang Wang
期刊：Frontiers in Pharmacology
影响因子 ：5.600
引用产品：CL-0002 CL-0010 CL-0052 CL-0075 CL-0109 CL-0185 CL-0200 CL-0222 CL-0227 CM-H019 PM150110 PM150210 PM150910
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MET inhibition enhances PARP inhibitor efficacy in castration-resistant prostate cancer by suppressing the ATM/ATR and PI3K/AKT pathways(2021/11/10)
作者：Sihai Zhou, Zhihong Dai, Liang Wang
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.295
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A pan-cancer analysis of DDR1 in prognostic signature and tumor immunity, drug resistance(2023/04/08)
作者：Longfei Yang, Yuwei Zhang, Yifan Tang
期刊：Scientific Reports
DOI：10.1038/s41598-023-27975-9
影响因子 ：4.600
引用产品：CL-0002 CL-0010 CL-0052 CL-0075 CL-0109 CL-0185 CL-0200 CL-0222 CL-0227 CM-H019 PM150110 PM150210 PM150910
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Identification of evodiamine as a suppressor of prostate cancer progression by reducing AR transcriptional activity via targeting Src(2021/10/28)
作者：Pei Cheng, Xiaofan Zhang, Xiaofu Wang
期刊：Endocrine
DOI：10.1007/s12020-021-02907-7
影响因子 ：3.925
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Analyzing roles of small nucleolar RNA host gene 25 from clinical, molecular target and tumor formation in prostate cancer(2023/06/10)
作者：Zelin Liu, Shuai Ke, Qinghua Wang
期刊：EXPERIMENTAL CELL RESEARCH
DOI：10.1016/j.yexcr.2023.113686
影响因子 ：3.700
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Crafting a Personalized Prognostic Model for Malignant Prostate Cancer Patients Using Risk Gene Signatures Discovered through TCGA-PRAD Mining, Machine Learning, and Single-Cell RNA-Sequencing(2023/06/07)
作者：Feng Lyu, Xianshu Gao, Mingwei Ma
期刊：Diagnostics
DOI：10.3390/diagnostics13121997
影响因子 ：3.600
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Silencing of lncRNA MALAT1 inhibits cell cycle progression via androgen receptor signaling in prostate cancer cells(2019/1/7)
作者：Xiaofan Dai, Lingyun Liu, Zuowen Liang
期刊：Pathology Research And Practice
影响因子 ：2.800
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GPX2 predicts recurrence-free survival and triggers the Wnt/β-catenin/EMT pathway in prostate cancer(2022/10/25)
作者：Ming Yang, Xudong Zhu, Yang Shen
期刊：PeerJ
影响因子 ：2.700
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Exploring the role of differentially expressed metabolic genes and their mechanisms in bone metastatic prostate cancer(2023/04/12)
作者：Qingfu Zhang, Peng Zhang, Zhongting Zhao
期刊：PeerJ
影响因子 ：2.700
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Hsa_circ_0074032 promotes prostate cancer progression through elevating homeobox A1 expression by serving as a microRNA-198 decoy(2021/11/19)
作者：Chuanshun Feng, Qinjun Wang, Ling Deng
期刊：Andrologia
影响因子 ：2.400
引用产品：164210 164210-50 CL-0075 CL-0143 CL-0185 CL-0200 CM-0200 PB180120 PM150110 PM150410 PM150910
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Hispidulin inhibits proliferation, migration, and invasion by promoting autophagy via regulation of PPARγ activation in prostate cancer cells and xenograft models(2020/12/15)
作者：Yuanyuan Wang, Shanqi Guo, Yingjie Jia
期刊：Bioscience Biotechnology and Biochemistry
影响因子 ：1.600
