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产品概述
| 名称 | ES-2 (人卵巢透明细胞癌细胞) (STR鉴定正确) |
| 别称 | ES2 |
| 背景描述 | ES-2细胞是建自45岁女性黑人的外科肿瘤标本，该肿瘤为低分化卵巢透明细胞癌。ES-2细胞最初生长在软琼脂中；ES-2细胞在裸鼠中成瘤。ES-2细胞对多种化疗药物包括阿霉素、顺铂、卡氯芥、依托泊甙等表现出低到中等的耐受性；ES-2细胞表达低水平的P糖蛋白。 |
| 种属 | 人 |
| 年龄（性别） | 女；47岁 |
| 组织来源 | 透明细胞癌，卵巢 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 卵巢癌细胞 |
| 生物安全等级 | 1 |
| 生长培养基 | McCoy’s 5A＋10% FBS＋1% P/S |
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2~3次/周 |
| 倍增时间 | ~28-36 hours |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
| 致瘤性 | Yes, tumors developed within 21 days at 100% frequency (5/5) in nude mice inoculated subcutaneously with 1×10^7 cells. |
| 基因表达情况 | P glycoprotein |
| 保藏机构 | ATCC; CRL-1978 BCRC; 60067 BCRJ; 0080 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,15 D2S1338 17,23 D3S1358 15,18 D5S818 11,13 D7S820 11 D8S1179 14 D13S317 11 D16S539 11,13 D18S51 13,15 D19S433 15,15.2 D21S11 32.2,33.2 FGA 21 PentaD 8,13 PentaE 13,16 TH01 9.300000000000001 TPOX 8,12 vWA 16,17 D1S1656 13,16 D6S1043 11,12 D12S391 20,21 -
STR鉴定图
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参考文献
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BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency(2022/10/05)
作者：Feixia Wang, Yifeng Liu, Feida Ni
期刊：Nature Communications
DOI：10.1038/s41467-022-33323-8
影响因子 ：17.6940
引用产品：CL-0079
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Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization(2017/05/08)
作者：H Guo, Q Zhu, X Yu
期刊：Oncogene
影响因子 ：8.756
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PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib(2022/09/05)
作者：Xiaocui Zhang, Meige Sun, Yisheng Jiao
期刊：Oxidative Medicine and Cellular Longevity
影响因子 ：7.3100
引用产品：164210 164210-50 CL-0013 CL-0079 CL-0178 P-CA-161 PM150110 PM150710
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Suppressive activities of mangiferin on human epithelial ovarian cancer(2020/06/15)
作者：Zheng Zeng, Caiji Lin, Siwen Wang
期刊：Phytomedicine
DOI：10.1016/j.phymed.2020.153267
影响因子 ：6.656
引用产品：CL-0079
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Naringenin suppresses epithelial ovarian cancer by inhibiting proliferation and modulating gut microbiota(2022/08/19)
作者：Caiji Lin, Zheng Zeng, Yiru Lin
期刊：PHYTOMEDICINE
DOI：10.1016/j.phymed.2022.154401
影响因子 ：6.6560
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Overexpression of IGF2BP3 as a Potential Oncogene in Ovarian Clear Cell Carcinoma(2020/01/30)
作者：Huidi Liu, Zheng Zeng , Mitra Afsharpad
期刊：Frontiers in Oncology
影响因子 ：5.738
引用产品：CL-0079
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Overexpression of IGF2BP3 as a Potential Oncogene in Ovarian Clear Cell Carcinoma(2020/01/30)
作者：Huidi Liu, Zheng Zeng, Caiji Lin
期刊：Front Oncol
影响因子 ：5.738
引用产品：CL-0079
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Enterolactone has stronger effects than enterodiol on ovarian cancer(2017/7/24)
作者：Liu Huidi, Liu Jianrui, Wang Siwen
期刊：Journal of Ovarian Research
影响因子 ：5.5060
引用产品：CL-0079
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RNA-binding protein IGF2BP2 enhances circ_0000745 abundancy and promotes aggressiveness and stemness of ovarian cancer cells via the microRNA-3187-3p/ERBB4/PI3K/AKT axis(2021/11/13)
作者：Shengtan Wang, Zaihong Li , Genhai Zhu
期刊：Journal of Ovarian Research
DOI：10.1186/s13048-021-00917-7
影响因子 ：5.5060
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MiR-29c downregulates tumor-expressed B7-H3 to mediate the antitumor NK-cell functions in ovarian cancer(2021/04/17)
作者：Mengqi Deng, Di Wu, Yanqin Zhang
期刊：Gynecologic Oncology
DOI：10.1016/j.ygyno.2021.04.013
影响因子 ：5.304
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Main components of pomegranate, ellagic acid and luteolin, inhibit metastasis of ovarian cancer by down-regulating MMP2 and MMP9(2017/11/27)
作者：Huidi Liu, Zheng Zeng, Siwen Wang
期刊：Cancer Biology & Therapy
DOI：10.1080/15384047.2017.1394542
影响因子 ：4.875
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Down-regulation of lncRNA BLACAT1 inhibits ovarian cancer progression by suppressing the Wnt/β-catenin signaling pathway via regulating miR-519d-3p(2020/2/24)
作者：Hua Yang, Yue Qi, Xinlu Wang
期刊：MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI：10.1007/s11010-020-03704-y.
影响因子 ：3.8420
引用产品：CL-0079
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CCNB1, Negatively Regulated by miR-559, Promotes the Proliferation, Migration, and Invasion of Ovarian Carcinoma Cells(2022/03/09)
作者：Xiaowen Yang, Shilin Zhou, Chunyue Yang
期刊：Molecular Biotechnology
DOI：10.1007/s12033-022-00463-7
影响因子 ：2.8600
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miR‑638 suppresses proliferation by negatively regulating high mobility group A1 in ovarian cancer cells(2021/9/20)
作者：Li Ma, Wei Zhang, Yaofeng Jin
期刊：Experimental and Therapeutic Medicine
影响因子 ：2.7510
