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产品概述
名称 | ES-2 (人卵巢透明细胞癌细胞) (STR鉴定正确) |
别称 | ES2 |
背景描述 | ES-2细胞是建自45岁女性黑人的外科肿瘤标本,该肿瘤为低分化卵巢透明细胞癌。ES-2细胞最初生长在软琼脂中;ES-2细胞在裸鼠中成瘤。ES-2细胞对多种化疗药物包括阿霉素、顺铂、卡氯芥、依托泊甙等表现出低到中等的耐受性;ES-2细胞表达低水平的P糖蛋白。 |
种属 | 人 |
年龄(性别) | 女;47岁 |
组织来源 | 透明细胞癌,卵巢 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 卵巢癌细胞 |
生物安全等级 | 1 |
生长培养基 | McCoy’s 5A+10% FBS+1% P/S |
推荐传代比例 | 1:3-1:4 |
推荐换液频率 | 2~3次/周 |
倍增时间 | ~28-36 hours |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养条件 | 气相:空气,95%;CO2,5% 温度:37℃ |
致瘤性 | Yes, tumors developed within 21 days at 100% frequency (5/5) in nude mice inoculated subcutaneously with 1×10^7 cells. |
基因表达情况 | P glycoprotein |
保藏机构 | ATCC; CRL-1978 BCRC; 60067 BCRJ; 0080 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,15 D2S1338 17,23 D3S1358 15,18 D5S818 11,13 D7S820 11 D8S1179 14 D13S317 11 D16S539 11,13 D18S51 13,15 D19S433 15,15.2 D21S11 32.2,33.2 FGA 21 PentaD 8,13 PentaE 13,16 TH01 9.3 TPOX 8,12 vWA 16,17 D1S1656 13,16 D6S1043 11,12 D12S391 20,21 -
STR鉴定图
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参考文献
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Tumor-secreted anterior gradient-2 binds to VEGF and FGF2 and enhances their activities by promoting their homodimerization(2017/05/08)
作者:H Guo, Q Zhu, X Yu
期刊:Oncogene
影响因子 :8.756
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Suppressive activities of mangiferin on human epithelial ovarian cancer(2020/06/15)
作者:Zheng Zeng, Caiji Lin, Siwen Wang
期刊:Phytomedicine
DOI:10.1016/j.phymed.2020.153267
影响因子 :6.656
引用产品:CL-0079
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Overexpression of IGF2BP3 as a Potential Oncogene in Ovarian Clear Cell Carcinoma(2020/01/30)
作者:Huidi Liu, Zheng Zeng , Mitra Afsharpad
期刊:Frontiers in Oncology
影响因子 :5.738
引用产品:CL-0079
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Overexpression of IGF2BP3 as a Potential Oncogene in Ovarian Clear Cell Carcinoma(2020/01/30)
作者:Huidi Liu, Zheng Zeng, Caiji Lin
期刊:Front Oncol
影响因子 :5.738
引用产品:CL-0079
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MiR-29c downregulates tumor-expressed B7-H3 to mediate the antitumor NK-cell functions in ovarian cancer(2021/04/17)
作者:Mengqi Deng, Di Wu, Yanqin Zhang
期刊:Gynecologic Oncology
DOI:10.1016/j.ygyno.2021.04.013
影响因子 :5.304
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Main components of pomegranate, ellagic acid and luteolin, inhibit metastasis of ovarian cancer by down-regulating MMP2 and MMP9(2017/11/27)
作者:Huidi Liu, Zheng Zeng, Siwen Wang
期刊:Cancer Biology & Therapy
DOI:10.1080/15384047.2017.1394542
影响因子 :4.875
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Down-regulation of lncRNA BLACAT1 inhibits ovarian cancer progression by suppressing the Wnt/β-catenin signaling pathway via regulating miR-519d-3p(2020/2/24)
作者:Hua Yang, Yue Qi, Xinlu Wang
期刊:MOLECULAR AND CELLULAR BIOCHEMISTRY
DOI:10.1007/s11010-020-03704-y.
影响因子 :3.8420
引用产品:CL-0079