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产品概述
名称 | H9c2(2-1) (大鼠心肌细胞) (种属鉴定正确) |
别称 | H9c2 (2-1); H9c2; H9C2 |
种属 | 大鼠 |
生长特性 | 贴壁细胞 |
细胞形态 | 成肌细胞样 |
生长培养基 | DMEM+10% FBS+1% P/S |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养条件 | 气相:空气,95%;CO2,5% 温度:37℃ |
推荐传代比例 | 1:2-1:4 |
推荐换液频率 | 2~3次/周 |
背景描述 | H9c2(2-1)细胞是一株由Kimes·B和Brandt·B从BD1X大鼠胚胎心脏组织的克隆细胞株亚克隆得到的细胞株;H9c2(2-1)细胞表现出许多骨骼肌的特性。H9c2(2-1)细胞中的成肌细胞能融合形成多核的肌管,并对乙酰胆碱的刺激发生反应。如果培养基中的血清浓度下降到1%,H9c2(2-1)细胞融合发生得很快。 |
年龄(性别) | 胚胎 |
组织来源 | 心脏,心肌层 |
细胞类型 | 自发永生化细胞 |
生物安全等级 | 1 |
受体表达情况 | acetylcholine, expressed |
基因表达情况 | myokinase; creatine phosphokinase; myosin |
保藏机构 | ATCC; CRL-1446 BCRC; 60096 BCRJ; 0098 ECACC; 88092904 |
种属鉴定
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种属鉴定图
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参考文献
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Xinshuaining preparation protects H9c2 cells from H2O2-induced oxidative damage through the PI3K/Akt/Nrf-2 signaling pathway(2022/10/20)
作者:Mingjun Han, Jie Lin, Yi Yang
期刊:CLINICAL AND EXPERIMENTAL HYPERTENSION
DOI:10.1080/10641963.2022.2131806
影响因子 :12.300
引用产品:CL-0089
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A Highly Sensitive Strategy for Fluorescence Imaging of MicroRNA in Living Cells and in Vivo Based on Graphene Oxide-Enhanced Signal Molecules Quenching of Molecular Beacon(2018/02/15)
作者:Limin Yang, Bo Liu, Meimei Wang
期刊:ACS Applied Materials & Interfaces
影响因子 :9.500
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Myocardial protection properties of parishins from the roots of Gastrodia elata Bl(2019/11/15)
作者:Qi Wang, Zhifeng Li, Dongxu Wang
期刊:Biomedicine & Pharmacotherapy
DOI:10.1016/j.biopha.2019.109645
影响因子 :7.500
引用产品:CL-0089
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Fluorescent Nanocomposite for Visualizing Cross-Talk between MicroRNA-21 and Hydrogen Peroxide in Ischemia-Reperfusion Injury in Live Cells and In Vivo(2016/11/02)
作者:Limin Yang, Yanfei Ren, Wei Pan
期刊:analytical chemistry
DOI:10.1021/acs.analchem.6b03701
影响因子 :7.400
引用产品:CL-0089
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Tanshinone IIA alleviates acute ethanol-induced myocardial apoptosis mainly through inhibiting the expression of PDCD4 and activating the PI3K/Akt pathway(2021/03/09)
作者:Hanyu Deng, Bo Yu, Yang Li
期刊:Phytotherapy Research
DOI:10.1002/ptr.7102
影响因子 :7.200
引用产品:CL-0089
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Lotus Bee Pollen Extract Inhibits Isoproterenol-Induced Hypertrophy via JAK2/STAT3 Signaling Pathway in Rat H9c2 Cells(2022/12/30)
作者:Shuo Han, Lifu Chen, Yi Zhang
期刊:Antioxidants
影响因子 :7.000
引用产品:CL-0089
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Bilobalide protects H9c2 cell from oxygen-glucose-deprivation-caused damage through upregulation of miR-27a(2019/12/01)
作者:Ailin Cao, Xiangting Li
期刊:Artificial Cells Nanomedicine and Biotechnology
DOI:PMID:31322008
影响因子 :6.355
引用产品:CL-0089
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Integrative applications of network pharmacology and molecular docking: An herbal formula ameliorates H9c2 cells injury through pyroptosis(2022/03/28)
作者:Zhongwen Qi, Zhipeng Yan, Yueyao Wang
期刊:Journal of Ginseng Research
影响因子 :6.300
引用产品:CL-0089
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Plasma exosomes from patients with acute myocardial infarction alleviate myocardial injury by inhibiting ferroptosis through miR-26b-5p/SLC7A11 axis(2023/04/01)
作者:Huili Li, Jiaxing Ding, Wei Liu
期刊:Life Sciences
影响因子 :6.100
引用产品:CL-0089
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Cardioprotective and anti-inflammatory effects of Caveolin 1 in experimental diabetic cardiomyopathy(2023/03/24)
作者:Wenyan Gong, Qibin Jiao, Jinghua Yuan
期刊:CLINICAL SCIENCE
影响因子 :6.000
引用产品:CL-0089
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Clemastine Fumarate Protects Against Myocardial Ischemia Reperfusion Injury by Activating the TLR4/PI3K/Akt Signaling Pathway(2020/02/10)
作者:Xiaoxiao Yuan, Zhaodong Juan, Rui Zhang
期刊: Frontiers in Pharmacology
影响因子 :5.988
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Long non-coding RNA UCA1 relieves cardiomyocytes H9c2 injury aroused by oxygen-glucose deprivation via declining miR-122(2019/12/01)
作者:Zaiwei Zhang
期刊: Artificial Cells Nanomedicine and Biotechnology
DOI:10.1080/21691401.2019.1652630
影响因子 :5.800
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Long non-coding RNA UCA1 relieves cardiomyocytes H9c2 injury aroused by oxygen-glucose deprivation via declining miR-122(2019/8/21)
作者:Zaiwei Zhang, Hu Li, Zhiyuan Cui
期刊:Artificial Cells Nanomedicine and Biotechnology
DOI:10.1080/21691401.2019.1652630
影响因子 :5.800
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Maresin1 ameliorates ventricular remodelling and arrhythmia in mice models of myocardial infarction via NRF2/HO-1 and TLR4/NF-kB signalling(2022/10/21)
作者:Fengyuan Wang, Yang Gong, Tao Chen
期刊:INTERNATIONAL IMMUNOPHARMACOLOGY
DOI:10.1016/j.intimp.2022.109369
影响因子 :5.600
引用产品:CL-0089
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Clemastine Fumarate Protects Against Myocardial Ischemia Reperfusion Injury by Activating the TLR4/PI3K/Akt Signaling Pathway(2020/02/10)
作者:Xiaoxiao Yuan, Zhaodong Juan, Rui Zhang
期刊:Frontiers in Pharmacology
影响因子 :5.600
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DNA methyltransferase 1 (DNMT1) suppresses mitophagy and aggravates heart failure via the microRNA-152-3p/ETS1/RhoH axis(2022/02/11)
作者:Zhuojun Deng, Jiaqi Yao, Na Xiao
期刊:Laboratory Investigation
DOI:10.1038/s41374-022-00740-8
影响因子 :5.502
引用产品:CL-0089
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Discovery of the signal pathways and major bioactive compounds responsible for the anti-hypoxia effect of Chinese cordyceps(2021/5/24)
作者:Hailin Long, Xuehong Qiu, Li Cao
期刊:Journal Of Ethnopharmacology
影响因子 :5.400
引用产品:CL-0089
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Sodium butyrate attenuates angiotensin II‐induced cardiac hypertrophy by inhibiting COX2/PGE2 pathway via a HDAC5/HDAC6‐dependent mechanism(2019/09/29)
作者:Linlin Zhang, Mokan Deng, Aihua Lu
期刊:Journal Of Cellular And Molecular Medicine
影响因子 :5.300
引用产品:CL-0089
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Qishen Yiqi Drop Pill, a novel compound Chinese traditional medicine protects against high glucose‐induced injury in cardiomyocytes(2019/07/06)
作者:Shouyan Zhang, Hao Wang, Lixia Li
期刊:Journal Of Cellular And Molecular Medicine
影响因子 :5.300
引用产品:CL-0089
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The Antioxidant and Anti-Inflammatory Effects of Flavonoids from Propolis via Nrf2 and NF-κB Pathways(2022/08/13)
作者:Wenzhen Xu, Han Lu, Yuan Yuan
期刊:Foods
影响因子 :5.200
引用产品:CL-0089
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Effect of sotagliflozin on ventricular arrhythmias in mice with myocardial infraction(2022/10/28)
作者:Gong Yang, Kong Bin, Shuai Wei
期刊:EUROPEAN JOURNAL OF PHARMACOLOGY
DOI:10.1016/j.ejphar.2022.175357
影响因子 :5.000
引用产品:CL-0089
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Ferroportin-mediated ferroptosis involved in new-onset atrial fibrillation with LPS-induced endotoxemia(2021/11/05)
作者:Jin Fang, Bin Kong, Wei Shuai
期刊:European Journal of Pharmacology
DOI:10.1016/j.ejphar.2021.174622
影响因子 :5.000
引用产品:CL-0089
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MicroRNA-381-3p signatures as a diagnostic marker in patients with sepsis and modulates sepsis-steered cardiac damage and inflammation by binding HMGB1(2021/11/12)
作者:Jian Liu, Yadong Yang, Rong Lu
期刊:Bioengineered
DOI:10.1080/21655979.2021.2006967
影响因子 :4.900
引用产品:CL-0089
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Xinyang Tablet attenuates chronic hypoxia-induced right ventricular remodeling via inhibiting cardiomyocytes apoptosis(2022/12/05)
作者:Anran Gao, Shuo Li, Xiaocui Tan
期刊:Chinese Medicine
DOI:10.1186/s13020-022-00689-2
影响因子 :4.900
引用产品:CL-0089
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Propofol protects ardiomyocytes from doxorubicin-induced toxic injury by activating the nuclear factor erythroid 2-related factor 2/glutathione peroxidase 4 signaling pathways(2022/04/01)
作者:Ziyun Lu, Zhiyi Liu, Bei Fang
期刊:Bioengineered
DOI:10.1080/21655979.2022.2036895
影响因子 :4.900
引用产品:CL-0089
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Sevoflurane inhibits the apoptosis of hypoxia/reoxygenation-induced cardiomyocytes via regulating miR-27a-3p-mediated autophagy(2021/10/07)
作者:Yang Zhang, Biming Zhan, Ying Hu
期刊:Journal Of Pharmacy And Pharmacology
影响因子 :4.810
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Mechanism of Action of Flavonoids of Oxytropis falcata on the Alleviation of Myocardial Ischemia–Reperfusion Injury(2022/03/05)
作者:Yang Guo, Benyin Zhang, Yanfeng Peng
期刊:Molecules
影响因子 :4.600
引用产品:CL-0089
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Puerarin Attenuates High-Glucose and High-Lipid-Induced Inflammatory Injury in H9c2 Cardiomyocytes via CAV3 Protein Upregulation(2023/06/28)
作者:YiFu Tian, CaiXia Zhou, XiaoYang Bu
期刊:Journal of Inflammation Research
影响因子 :4.500
引用产品:CL-0089
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Protective Effect of Lemon Peel Extract on Oxidative Stress in H9c2 Rat Heart Cell Injury(2021/05/14)
作者:Jun Wang, Yulin Zhai, Mingguang Ou
期刊:Drug Design Development and Therapy
影响因子 :4.319
引用产品:CL-0089
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Emodin protects H9c2 cells against hypoxia‐induced injury via regulation of miR‐26a/survivin and the JAK1/STAT3 pathway(2019/01/30)
作者:Jiancheng Huang, Xiaobing Li
期刊:Journal of Cellular Biochemistry
影响因子 :4.000
引用产品:CL-0089
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EEF1A2 accelerates the protein translation of chemokine in rat myocardial cells induced by ischemia-reperfusion(2023/04/07)
作者:Zijie Zhang, Zhixiang Sun, Haijian Liu
期刊:Heliyon
DOI:10.1016/j.heliyon.2023.e15305
影响因子 :4.000
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Klotho protects against aged myocardial cells by attenuating ferroptosis(2023/03/28)
作者:Xicheng Xiong, Gang Wang, Yiping Wang
期刊:EXPERIMENTAL GERONTOLOGY
DOI:10.1016/j.exger.2023.112157
影响因子 :3.900
引用产品:CL-0089
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Knockdown of TUG1 aggravates hypoxia-induced myocardial cell injury via regulation of miR-144-3p/Notch1(2019/6/1)
作者:Bo Zhu, Zhen Xia, Zirong Xia,
期刊:RSC Advances
影响因子 :3.900
引用产品:CL-0089
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MicroRNA-494 regulates high glucose-induced cardiomyocyte apoptosis and autophagy by PI3K/AKT/mTOR signalling pathway(2023/02/11)
作者:Shuwei Ning, Siqi Zhang, Zhikun Guo
期刊:ESC Heart Failure
影响因子 :3.800
引用产品:CL-0089
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Lipopolysaccharide-stimulated bone marrow mesenchymal stem cells-derived exosomes inhibit H2O2-induced cardiomyocyte inflammation and oxidative stress via regulating miR-181a-5p/ATF2 axis.(2020/10/24)
作者:H-Y Liu, L-F Yu, T-G Zhou
期刊:European Review for Medical and Pharmacological Sciences
DOI:10.26355/eurrev_202010_23224
影响因子 :3.784
引用产品:CL-0089
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Identification and verification of IGFBP3 and YTHDC1 as biomarkers associated with immune infiltration and mitophagy in hypertrophic cardiomyopathy(2022/10/04)
作者:Yao Li, Wei Zhang, Yan Dai
期刊:Frontiers in Genetics
影响因子 :3.700
引用产品:CL-0089
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Silicate Ions Derived from Calcium Silicate Extract Decelerate Ang II-Induced Cardiac Remodeling(2023/03/15)
作者:Xin Li, Yanxin Zhang, Qishu Jin
期刊:Tissue Engineering and Regenerative Medicine
DOI:10.1007/s13770-023-00523-2
影响因子 :3.600
引用产品:CL-0089
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Integrating network pharmacology and experimental validation to decipher the mechanism of action of Jingfang Granule in the treatment of viral myocarditis(2023/03/24)
作者:Tian Yao, Bowen Sun, Yunlun Li
期刊:NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
DOI:10.1007/s00210-023-02464-y
影响因子 :3.600
引用产品:CL-0089
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LncRNA FOXD3-AS1 aggravates myocardial ischemia/reperfusion injury by inactivating the Redd1/AKT/GSK3β/Nrf2 signaling pathway via the miR-128/TXNIP axis(2022/09/13)
作者:Baozeng Chen, Lingling Zheng, Teng Zhu
期刊:JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
影响因子 :3.600
引用产品:CL-0089
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Melatonin Engineered Adipose-Derived Biomimetic Nanovesicles Regulate Mitochondrial Functions and Promote Myocardial Repair in Myocardial Infarction(2022/03/23)
作者:Yang Zhang, Ning Yang, Xu Huang
期刊:Frontiers in Cardiovascular Medicine
影响因子 :3.600
引用产品:CL-0089
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SIRT6 Protects Against Myocardial Ischemia–Reperfusion Injury by Attenuating Aging-Related CHMP2B Accumulation(2022/03/02)
作者:Xiaokang Li, Lin Liu , Wenhua Jiang
期刊:Journal of Cardiovascular Translational Research
DOI:10.1007/s12265-021-10184-y
影响因子 :3.400
引用产品:CL-0089
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Cardioprotective effects and concentration-response relationship of aminoalcohol-diterpenoid alkaloids from Aconitum carmichaelii(2020/12/31)
作者:Xiaoya Wang, Qinmei Zhou, Li Guo
期刊:Fitoterapia
DOI:10.1016/j.fitote.2020.104822
影响因子 :3.400
引用产品:CL-0089
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Long non‑coding RNA MEG3 knockdown alleviates hypoxia‑induced injury in rat cardiomyocytes via the miR‑325‑3p/TRPV4 axis(2020/11/3)
作者:Ya Zhou, Xianguo Li, Dong Zhao
期刊:Molecular Medicine Reports
影响因子 :3.400
引用产品:CL-0089
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MicroRNA‑494 suppresses hypoxia/reoxygenation‑induced cardiomyocyte apoptosis and autophagy via the PI3K/AKT/mTOR signaling pathway by targeting SIRT1(2020/10/26)
作者:Shuwei Ning, Zhiying Li, Zhenyu Ji
期刊:Molecular Medicine Reports
影响因子 :3.400
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H2S regulation of ferroptosis attenuates sepsis‑induced cardiomyopathy(2022/09/12)
作者:Guodong Cao, Youcheng Zeng, Yuhan Zhao
期刊:Molecular Medicine Reports
影响因子 :3.400
引用产品:CL-0089
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CaMKII inhibition protects against hyperthyroid arrhythmias and adverse myocardial remodeling(2022/04/20)
作者:Daan Nie, Chaorui Xia, Zhiyu Wang
期刊:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI:10.1016/j.bbrc.2022.04.082
影响因子 :3.322
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MiR‐129‐5p alleviates myocardial injury by targeting suppressor of cytokine signaling 2 after ischemia/reperfusion(2020/04/07)
作者:Rui Ma, Xin Chen, Yue Ma
期刊:Kaohsiung Journal Of Medical Sciences
影响因子 :3.300
引用产品:CL-0089
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Trophoblast Stem-Cell-Derived Exosomes Alleviate Cardiotoxicity of Doxorubicin via Improving Mfn2-Mediated Mitochondrial Fusion(2023/01/07)
作者:Junfeng Duan, Xiaoli Liu, Song Shen
期刊:Cardiovascular Toxicology
DOI:10.1007/s12012-022-09774-2
影响因子 :3.200
引用产品:CL-0089
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Progesterone Changes the Pregnancy-Induced Adaptation of Cardiomyocyte Kv2.1 Channels via MicroRNA-29b(2022/04/07)
作者:Shuang Liang, Yushuang Sun, Lu Li
期刊:Cardiovascular Therapeutics
影响因子 :3.100
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Sevoflurane preconditioning attenuates hypoxia/reoxygenation injury of H9c2 cardiomyocytes by activation of the HIF-1/PDK-1 pathway(2020/12/21)
作者:Tianliang Hou, Haiping Ma, Haixia Wang
期刊:PeerJ
影响因子 :3.061
引用产品:CL-0089
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Resveratrol ameliorates myocardial ischemia/reperfusion induced necroptosis through inhibition of the Hippo pathway(2022/12/23)
作者:Hao Tian, Yonghong Xiong, Zhongyuan Xia
期刊:JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
DOI:10.1007/s10863-022-09954-3
影响因子 :3.000
引用产品:CL-0089
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Empagliflozin alleviates ethanol‐induced cardiomyocyte injury through inhibition of mitochondrial apoptosis via a SIRT1/PTEN/Akt pathway(2021/2/1)
作者:Ge Tian, Yang Yu, Hanyu Deng
期刊:Clinical And Experimental Pharmacology And Physiology
影响因子 :2.900
引用产品:CL-0089
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DL‑3‑n‑butylphthalide protects H9c2 cardiomyoblasts from ischemia/reperfusion injury by regulating HSP70 expression via PI3K/AKT pathway activation(2021/7/15)
作者:Yunchen Yu, Yuying Zhu, Xiaotong Sun
期刊:Experimental and therapeutic medicine
影响因子 :2.700
引用产品:CL-0089
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Clusterin regulates TRPM2 to protect against myocardial injury induced by acute myocardial infarction injury(2023/02/13)
作者:Dalei Li, Mengying Wang, Rong Fan
期刊:TISSUE & CELL
DOI:10.1016/j.tice.2023.102038
影响因子 :2.600
引用产品:CL-0089
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Knockdown of HDAC9 attenuates sepsis-induced myocardial injury and inflammatory response(2023/03/13)
作者:Long YANG, Chunxue WU, Ying CUI
期刊:EXPERIMENTAL ANIMALS
影响因子 :2.400
引用产品:CL-0089
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Co-cultured the MSCs and cardiomyocytes can promote the growth of cardiomyocytes(2018/01/25)
作者:Hui Jiang, Huishan Wang, Tao Liu
期刊:Cytotechnology
影响因子 :2.200
引用产品:CL-0089
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Four new compounds isolated from the rhizomes of Phedimus aizoon (L.) ‘t Hart(2023/04/17)
作者:Xin Zhang, Lu Gao, Qiao Li
期刊:NATURAL PRODUCT RESEARCH
DOI:10.1080/14786419.2023.2198711
影响因子 :2.200
引用产品:CL-0089
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Interleukin-17 aggravates right ventricular remodeling via activating STAT3 under both normoxia and hypoxia(2021/5/21)
作者:Jing Huang, Wei Zhang, Cailian Zhang
期刊:BMC Cardiovascular Disorders
DOI:10.1186/s12872-021-02069-4
影响因子 :2.100
引用产品:CL-0089
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Vitamin C alleviates LPS-induced myocardial injury by inhibiting pyroptosis via the ROS-AKT/mTOR signalling pathway(2022/12/22)
作者:Pu Zhang, Meirong Zang, Zhenzhen Sang
期刊:BMC Cardiovascular Disorders
DOI:10.1186/s12872-022-03014-9
影响因子 :2.100
引用产品:CL-0089
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Adenosine 2 receptor regulates autophagy and apoptosis to alleviate ischemia reperfusion injury in type 2 diabetes via IRE-1 signaling(2023/03/24)
作者:Yacouba Moukeila Mohamed Bassirou, Thokerunga Erick, He Feng, Bongolo Christian Cedric
期刊:BMC Cardiovascular Disorders
DOI:10.1186/s12872-023-03116-y
影响因子 :2.100
引用产品:CL-0089
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Resveratrol Attenuates Sepsis-Induced Cardiomyopathy in Rats through Anti-Ferroptosis via the Sirt1/Nrf2 Pathway(2022/12/28)
作者:Youcheng Zeng, Guodong Cao, Liang Lin
期刊:JOURNAL OF INVESTIGATIVE SURGERY
DOI:10.1080/08941939.2022.2157521
影响因子 :1.900
引用产品:CL-0089
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Diagnostic and prognostic value of miR-486-5p, miR-451a, miR-21-5p and monocyte to high-density lipoprotein cholesterol ratio in patients with acute myocardial infarction(2022/10/10)
作者:Liwenjing Xu, Lu Tian, Zhenrong Yan
期刊:HEART AND VESSELS
DOI:10.1007/s00380-022-02172-2
影响因子 :1.500
引用产品:CL-0089
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Protective Effect of Sodium Hydrosulfide on Lipopolysaccharide Induced Myocardial Cell Injury Model: Involvement of Oxidative Stress and Endoplasmic Reticulum Stress(2023/03/03)
作者:Xin Peng, G. D. Cao, Y. C. Zeng
期刊:INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
DOI:10.36468/pharmaceutical-sciences.spl.625
影响因子 :0.500
引用产品:CL-0089
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Bellidifolin from Gentianella acuta (Michx.) Hulten protects H9c2 cells from hydrogen peroxide-induced injury via the PI3K-Akt signal pathway(2022/08/17)
作者:Siqi Li, Congying Huang, Xing Li
期刊:Toxicology Reports
DOI:10.1016/j.toxrep.2022.08.006
影响因子 :0.000
引用产品:CL-0089
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Tubeimoside I Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating SIRT3(2023/01/14)
作者:Wei Zhang, Zhixing Fan, Fengyuan Wang
期刊:Oxidative Medicine and Cellular Longevity
影响因子 :0.000
引用产品:CL-0089