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| 名称 | Hep 3B2.1-7 (人肝癌细胞) (STR鉴定正确) |
| 别称 | Hep 3B2_1-7; Hep 3B2; HEP-3B2; HEP3B2; Hep-3B; HEP-3B; Hep 3B; Hep3B; HEP3B |
| 背景描述 | Hep 3B2.1-7细胞是来自8岁男性黑人的组织。Hep 3B2.1-7细胞的染色体模式数目为60，在裸鼠中能致瘤。Hep 3B2.1-7细胞整合了完整的乙型肝炎病毒基因组，需在2级生物安全防护下操作。 |
| 种属 | 人 |
| 年龄（性别） | 男；8岁 |
| 组织来源 | 肝细胞癌，肝 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 肝胆癌细胞 |
| 生物安全等级 | 2 |
| 生长培养基 | MEM（含NEAA）＋10% FBS＋1% P/S |
| 推荐传代比例 | 1:2-1:3 |
| 推荐换液频率 | 2~3次/周 |
| 倍增时间 | ~40-50 hours |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
| 致瘤性 | Yes, in nude mice. |
| 基因表达情况 | alpha fetoprotein (alpha-fetoprotein); hepatitis B surface antigen (HBsAg); albumin; alpha2 macroglobulin (alpha-2-macroglobulin); alpha1 antitrypsin (alpha-1-antitrypsin); transferrin;, alpha1 antichymotrypsin (alpha-1-antichymotrypsin); haptoglobin; ceruloplasmin; plasminogen; complement (C3, C4); C3 activator; fibrinogen; alpha1 acid glycoprotein (alpha-1 acid glycoprotein);, alpha2 HS glycoprotein (alpha-2-HS-glycoprotein); beta lipoprotein (beta-lipoprotein); retinol binding protein (retinol- |
| 保藏机构 | ATCC; HB-8064 BCRC; 60434 BCRJ; 0357 DSMZ; ACC-93 ECACC; 86062703 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 8 D2S1338 21,25 D3S1358 15 D5S818 13 D7S820 8,10 D8S1179 12 D13S317 12,14 D16S539 10 D18S51 20 D19S433 12.2,14 D21S11 30,31 FGA 18 PentaD 12,14 PentaE 5,16 TH01 6,7 TPOX 9 vWA 17 D6S1043 12,17 D12S391 17 D2S441 10,12 -
STR鉴定图
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参考文献
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Stabilization of SETD3 by deubiquitinase USP27 enhances cell proliferation and hepatocellular carcinoma progression(2022/01/12)
作者：Tingting Zou, Yang Wang, Ling Dong
期刊：CELLULAR AND MOLECULAR LIFE SCIENCES
DOI：10.1007/s00018-021-04118-9
影响因子 ：9.2070
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USP27-mediated Cyclin E stabilization drives cell cycle progression and hepatocellular tumorigenesis(2018/03/02)
作者：Ling Dong, Le Yu, Chunrong Bai
期刊：Oncogene
影响因子 ：8.756
引用产品：CL-0102
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LAGE3 promoted cell proliferation, migration, and invasion and inhibited cell apoptosis of hepatocellular carcinoma by facilitating the JNK and ERK signaling pathway(2021/11/27)
作者：Ying Xing,Yang Liu，Zhong Qi
期刊：Cellular & Molecular Biology Letters
DOI：10.1186/s11658-021-00295-4
影响因子 ：8.7020
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SGOL2 is a novel prognostic marker and fosters disease progression via a MAD2-mediated pathway in hepatocellular carcinoma(2022/11/15)
作者：Hu, Qingqing, Liu, Qiuhong, Zhao, Yalei, Zhang, Lingjian, Li, Lanjuan
期刊：Biomarker Research
DOI：10.1186/s40364-022-00422-z
影响因子 ：8.6330
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An NAD+ -Dependent Deacetylase SIRT7 Promotes HCC Development Through Deacetylation of USP39(2020/07/09)
作者：Ling Dong, Le Yu, Hui Li
期刊：iScience
DOI：10.1016/j.isci.2020.101351
影响因子 ：6.107
引用产品：CL-0102
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Lack of MOF Decreases Susceptibility to Hypoxia and Promotes Multidrug Resistance in Hepatocellular Carcinoma via HIF-1α(2021/09/01)
作者：Meng Wang, Haoyu Liu, Xu Zhang
期刊：Frontiers in Cell and Developmental Biology
影响因子 ：6.081
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VEZF1, destabilized by STUB1, affects cellular growth and metastasis of hepatocellular carcinoma by transcriptionally regulating PAQR4(2022/10/14)
作者：Xiaobao Shi, Pengfei Zhao, Gang Zhao
期刊：CANCER GENE THERAPY
DOI：10.1038/s41417-022-00540-8
影响因子 ：5.8540
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Proteoglycan-4 predicts good prognosis in patients with hepatocellular carcinoma receiving transcatheter arterial chemoembolization and inhibits cancer cell migration in vitro.(2022/11/11)
作者：Yuan Guo, Hong Tao Hu, Shi Jun Xu, Wei Li Xia, Yan Zhao, Xiao Hui Zhao, Wen Bo Zhu, Fang Ting Li, Hai Liang Li
期刊：Frontiers in Oncology
影响因子 ：5.7380
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The bioactive ingredients in Actinidia chinensis Planch. Inhibit liver cancer by inducing apoptosis(2021/08/21)
作者：Zongchao Hong, Yi Lu, Chongwang Ran
期刊：Journal Of Ethnopharmacology
影响因子 ：5.195
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ZSCAN16-AS1 expedites hepatocellular carcinoma progression via modulating the miR-181c-5p/SPAG9 axis to activate the JNK pathway(2021/06/07)
作者：Jianwen Liu, Ruiqing Liu, Yuyan Liu
期刊：Cell Cycle
DOI：10.1080/15384101.2021.1919828
影响因子 ：5.173
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LncRNA KCNQ1OT1 inhibits the radiosensitivity and promotes the tumorigenesis of hepatocellular carcinoma via the miR-146a-5p/ACER3 axis(2020/09/16)
作者：Ganghua Yang, Lijing Zhou, Qinhong Xu
期刊：Cell Cycle
DOI：10.1080/15384101.2020.1809259
影响因子 ：5.173
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Predicting therapeutic drugs for hepatocellular carcinoma based on tissue-specific pathways(2021/02/09)
作者：Liang Yu, Meng Wang, Yang Yang
期刊：Plos Computational Biology
DOI：10.1371/journal.pcbi.1008696
影响因子 ：4.779
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Long noncoding RNA HULC regulates the NF-κB pathway and represents a promising prognostic biomarker in liver cancer(2022/10/10)
作者：Shihai Liu, Lakshmi Huttad, Guifang He
期刊：Cancer Medicine
影响因子 ：4.7110
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Lidocaine Inhibits Hepatocellular Carcinoma Development by Modulating circ_ITCH/miR-421/CPEB3 Axis(2021/1/12)
作者：Lili Zhao, Ning Ma, Gaihong Liu
期刊：Digestive Diseases And Sciences
DOI：10.1007/s10620-020-06787-1
影响因子 ：3.4870
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Role of SLC39A6 in the development and progression of liver cancer(2022/01/11)
作者：Zhen Wan, Xuzhen Wang
期刊：Oncology Letters
影响因子 ：3.1110
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Activation of YAP1 by STK25 contributes to the progression of hepatocellular carcinoma(2022/04/06)
作者：Jiong Jiang, Ying Zheng, Fenrong Chen
期刊：TISSUE & CELL
DOI：10.1016/j.tice.2022.101797
影响因子 ：2.5860
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Propofol enhances the lethality of cisplatin on liver cancer cells by up-regulating miR-195-5p(2021/11/19)
作者：Lan Gao, Xiufeng Zhang
期刊：Tissue & Cell
DOI：10.1016/j.tice.2021.101680
影响因子 ：2.5860
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CKS1B promotes the progression of hepatocellular carcinoma by activating JAK/STAT3 signal pathway(2021/07/14)
作者：Xitao Liu, Defang Zhao
期刊：Animal Cells and Systems
DOI：10.1080/19768354.2021.1953142
影响因子 ：2.3980
