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产品概述
名称 | HL-7702 [L-02; LO2] (人正常肝细胞) (Hela污染细胞系,暂不供应) |
别称 | L02; LO2; HL-7702; HL7702 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
背景描述 | HL-7702 [L-02]细胞是人正常肝细胞;HL-7702 [L-02]细胞群体倍增时间约为20小时,细胞形态呈上皮样细胞。在电子显微镜下,亦显示上皮细胞所具有的桥粒和张力原纤维,HL-7702 [L-02]细胞增殖迅速,AFP与CK-19表达阴性,ALB表达在10μg/ml水平,部分细胞多次传代后发生形态变异,ALB表达缺失。(STR检测位点同HELA) |
生长培养基 | RPMI-1640+10% FBS+1% P/S |
推荐传代比例 | 1:3-1:4 |
推荐换液频率 | 2~3次/周 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养条件 | 气相:空气,95%;CO2,5% 温度:37℃ |
参考文献
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Irisin alleviates liver ischemia-reperfusion injury by inhibiting excessive mitochondrial fission, promoting mitochondrial biogenesis and decreasing oxidative stress(2019.01)
作者:Jianbin Bi, Jia Zhang, Yifan Ren,
期刊:Redox Biology
DOI:10.1016/j.redox.2018.10.019
影响因子 :11.799
引用产品:CL-0111
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The protective effects of fibroblast growth factor 10 against hepatic ischemia-reperfusion injury in mice(2021/1/7)
作者:Santie Li, Zhongxin Zhu, Mei Xue
期刊:Redox Biology
DOI:10.1016/j.redox.2021.101859
影响因子 :11.799
引用产品:CL-0111
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Nrf2 mitigates prolonged PM2.5 exposure-triggered liver inflammation by positively regulating SIKE activity: Protection by Juglanin(2020/07/17)
作者:Chenxu Ge, Jun Tan, Shaoyu Zhong
期刊:Redox Biology
DOI:10.1016/j.redox.2020.101645
影响因子 :11.799
引用产品:CL-0111
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Serum irisin levels are decreased in patients with sepsis, and exogenous irisin suppresses ferroptosis in the liver of septic mice(2020/9/29)
作者:Shasha Wei, Jianbin Bi, Lifei Yang
期刊:Clinical and Translational Medicine
DOI:10.1002/ctm2.173
影响因子 :11.492
引用产品:CL-0111
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An endogenous stimulus detonated nanocluster-bomb for contrast-enhanced cancer imaging and combination therapy(2021/8/17)
作者:Huanhuan Sun, Wenjie Ma, Shuangdi Duan
期刊:Chemical Science
影响因子 :9.825
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Circular RNA hsa_circ_101555 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-145-5p and regulating CDCA3 expression(2021/4/6)
作者:Xiaoguang Gu, Jianan Zhang, Yajuan Ran
期刊:Cell Death & Disease
DOI:10.1038/s41419-021-03626-7
影响因子 :8.469
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Epigenetic silencing of ZIC4 contributes to cancer progression in hepatocellular carcinoma(2020/10/23)
作者:Wenbiao Chen, Donge Tang, Dongxin Tang
期刊:Cell Death & Disease
DOI:10.1038/s41419-020-03109-1
影响因子 :8.469
引用产品:CL-0111
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Polystyrene microplastics-triggered mitophagy and oxidative burst via activation of PERK pathway(2021/3/26)
作者:Lingai Pan, Dongke Yu, Yuan Zhang
期刊:Science Of The Total Environment
DOI:10.1016/j.scitotenv.2021.146753
影响因子 :7.963
引用产品:CL-0111
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A single nanowire sensor for intracellular glucose detection(2019.06.06)
作者:Quan-Lan Liao, Hong Jiang, Xin-Wei Zhang
期刊:Nanoscale
影响因子 :7.790
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Discovery of 8,9-seco-ent-Kaurane Diterpenoids as Potential Leads for the Treatment of Triple-Negative Breast Cancer(2021/07/08)
作者:Run-Zhu Fan, Lin Chen, Tong Su
期刊:Journal Of Medicinal Chemistry
DOI:10.1021/acs.jmedchem.1c00166
影响因子 :7.446
引用产品:CL-0111
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Prolonged PM2.5 exposure elevates risk of oxidative stress-driven nonalcoholic fatty liver disease by triggering increase of dyslipidemia(2019.01)
作者:Min-Xuan Xu, Chen-Xu Ge, Yu-Ting Qin
期刊:Free Radical Biology and Medicine
DOI:10.1016/j.freeradbiomed.2018.11.016
影响因子 :7.376
引用产品:CL-0111
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Dual-Aptamer Modified Graphene Field-Effect Transistor Nanosensor for Label-Free and Specific Detection of Hepatocellular Carcinoma-Derived Microvesicles(2020/3/3)
作者:Ding Wu, Yi Yu, Dan Jin
期刊:Anal Chem
DOI:10.1021/acs.analchem.9b05531
影响因子 :6.986
引用产品:CL-0111
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Asiatic acid ameliorates acute hepatic injury by reducing endoplasmic reticulum stress and triggering hepatocyte autophagy(2020.09)
作者:Xiaohong Pang, Qian Qiao, Sayyaphone Vonglorkham
期刊:Biomedicine & Pharmacotherapy
DOI:10.1016/j.biopha.2020.110375
影响因子 :6.529
引用产品:CL-0111
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Neonicotinoid insecticides triggers mitochondrial bioenergetic dysfunction via manipulating ROS-calcium influx pathway in the liver(2021/08/20)
作者:Siwen Li, Yang Cao, Qiangwen Pan
期刊:Ecotoxicology And Environmental Safety
DOI:10.1016/j.ecoenv.2021.112690
影响因子 :6.291
引用产品:CL-0111
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Detecting lipid droplets polarity: Silicone-based unique fluorescent probe for cancer diagnosis in living cells(2020/12/29)
作者:Fengqing Gai, Yujing Zuo, Weiying Lin
期刊:Talanta
DOI:10.1016/j.talanta.2020.122059
影响因子 :6.057
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Tanshinone I induces cell apoptosis by reactive oxygen species-mediated endoplasmic reticulum stress and by suppressing p53/DRAM-mediated autophagy in human hepatocellular carcinoma(2020.02.04)
作者:Xu Liu, JiKui Liu
期刊:Artificial Cells, Nanomedicine, and Biotechnology
DOI:10.1080/21691401.2019.1709862
影响因子 :5.678
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Different Influences of trans Fatty Acids on the Phospholipase A2 and Arachidonic Acid Metabolic Pathway in Hepatocytes(2021/4/5)
作者:Qian Zou, Meng Wei, Niu Zhang
期刊:Journal Of Agricultural And Food Chemistry
影响因子 :5.279
引用产品:CL-0111
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Effects of the Major Structured Triacylglycerols in Human Milk on Lipid Metabolism of Hepatocyte Cells in Vitro(2020/12/28)
作者:Yanping Wu, Niu Zhang, Zeyuan Deng
期刊:Journal Of Agricultural And Food Chemistry
影响因子 :5.279
引用产品:CL-0111
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PIGU promotes hepatocellular carcinoma progression throughactivating NF-κB pathway and increasing immune escape(2020/9/21)
作者:Xin Wei, Wenjie Yang, Feng Zhang
期刊:Life Sciences
影响因子 :5.037
引用产品:CL-0111
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Inhibiting effect of MicroRNA-3619-5p/PSMD10 axis on liver cancer cell growth in vivo and in vitro(2020/5/11)
作者:Peipei Hao, Fengming Yue, Xian Xian
期刊:Life Sciences
影响因子 :5.037
引用产品:CL-0111
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Medium- and long-chain triglycerides attenuate lipid accumulation and regulate the expression of proteins related to lipid metabolism in oleic acid-induced lipid deposition in human hepatic LO2 cells(2021/02/01)
作者:Bin Peng, Ting Luo, Fang Chen
期刊:Journal of Functional Foods
影响因子 :4.451
引用产品:CL-0111
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Preparation, In Vivo and In Vitro Release of Polyethylene Glycol Monomethyl Ether-Polymandelic Acid Microspheres Loaded Panax Notoginseng Saponins(2019/05/27)
作者:Yi He, Hongli Li, Xiangyu Zheng
期刊:Molecules
影响因子 :4.411
引用产品:CL-0111
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High payload and targeted release of anthracyclines by aptamer-tethered DNA nanotrains — Thermodynamic and release kinetic study(2020.05.30)
作者:Wenxin Pei, Min Liu, Yushu Wu
期刊:European Journal of Pharmaceutical Sciences
DOI:10.1016/j.ejps.2020.105319
影响因子 :4.384
引用产品:CL-0111
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Application of Sustainable Natural Resources in Agriculture: Acaricidal and Enzyme Inhibitory Activities of Naphthoquinones and Their Analogs against Psoroptes cuniculi(2018/01/25)
作者:Xiao-Fei Shang , Ying-Qian Liu , Xiao Guo
期刊:Scientific Reports
DOI:10.1038/s41598-018-19964-0
影响因子 :4.379
引用产品:CL-0111
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Phillygenin inhibits LPS-induced activation and inflammation of LX2 cells by TLR4/MyD88/NF-κB signaling pathway(2020.02.10)
作者:Naihua Hu, Cheng Wang, Xuyang Dai
期刊:Journal of Ethnopharmacology
影响因子 :4.360
引用产品:CL-0111
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Yi-Qi-Jian-Pi formula modulates the PI3K/AKT signaling pathway to attenuate acute-on-chronic liver failure by suppressing hypoxic injury and apoptosis in vivo and in vitro(2021/07/12)
作者:Li Tang, Feixia Wang, Lingyan Xiao
期刊:Journal Of Ethnopharmacology
影响因子 :4.360
引用产品:CL-0111
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Hsa_circ_0005915 promotes N,N-dimethylformamide-induced oxidative stress in HL-7702 cells through NRF2/ARE axis(2021/6/19)
作者:Ziqi Liu, Qianmei He, Ye Liu
期刊:Toxicology
影响因子 :4.221
引用产品:CL-0111
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LncRNA MYCNOS facilitates proliferation and invasion in hepatocellular carcinoma by regulating miR-340(2019/11/27)
作者:Junfeng Yu, Zhejian Ou, Yangyang Lei
期刊:Human Cell
DOI:10.1007/s13577-019-00303-y
影响因子 :4.174
引用产品:CL-0111
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The miR-122 inhibition alleviates lipid accumulation and inflammation in NAFLD cell model(2019.07.16)
作者:Yiyi Hu
期刊:Archives of Physiology and Biochemistry
DOI:10.1080/13813455.2019.1640744
影响因子 :4.076
引用产品:CL-0111
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Preparation and In Vitro Release of Total Alkaloids from Alstonia Scholaris Leaves Loaded mPEG-PLA Microspheres(2019/5/6)
作者:Xiangyu Zheng, Hongli Li, Yi He
期刊:Materials
影响因子 :3.6230
引用产品:CL-0111
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18-GA-Suc Modified Liposome Loading Cantharidin for Augmenting Hepatic Specificity: Preparation, Characterization, Antitumor Effects, and Liver-Targeting Efficiency(2020.06)
作者:Kun Zhu, Lili Zhou, Manshu Zou
期刊:Journal of Pharmaceutical Sciences
DOI:10.1016/j.xphs.2020.03.001
影响因子 :3.534
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Fucoxanthin Exerts Cytoprotective Effects against Hydrogen Peroxide-induced Oxidative Damage in L02 Cells(2018.11.15)
作者:Xia Wang, Yan-jun Cui, Jia Qi
期刊:BioMed Research International
影响因子 :3.411
引用产品:CL-0111
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miR-34a inhibits cell proliferation by targeting SATB2 in hepatocellular carcinoma(2018.12.06)
作者:Gang Wu, Zhixi Li, Youyu Wang, Xueming Ju
期刊:BioMed Research International
影响因子 :3.411
引用产品:CL-0111
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Lipid storage droplet protein 5 reduces sodium palmitate‑induced lipotoxicity in human normal liver cells by regulating lipid metabolism‑related factors(2019.06.06)
作者:Xueqiang Ma, Feiyong Cheng, Keyu Yuan, Kexiang Jiang
期刊:Molecular Medicine Reports
影响因子 :2.952
引用产品:CL-0111
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Acaricidal activity and enzyme inhibitory activity of active compounds of essential oils against Psoroptes cuniculi(2019.03)
作者:Xiao-Fei Shang, Li-Xia Dai, Ying-Qian Liu
期刊:Veterinary Parasitology
DOI:10.1016/j.vetpar.2019.01.013
影响因子 :2.738
引用产品:CL-0111
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AMPK Activation of Flavonoids from Psidium guajava Leaves in L6 Rat Myoblast Cells and L02 Human Hepatic Cells(2019.12.23)
作者:Jiankuan Li, Yujing Zhao, Lingya Cao
期刊:Evid Based Complement Alternat Med
影响因子 :2.629
引用产品:CL-0111