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产品概述
名称 | MDA-MB-231(人乳腺癌细胞) (STR鉴定正确) |
别称 | MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA231; MB231; MD Anderson-Metastatic Breast-231 |
种属 | 人类 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
生长培养基:
培养条件:
气相:空气,100%, 温度:37℃
|
培养方案B(可选) |
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 1:2-1:4 |
推荐换液频率 | 2-3次/周 |
注意事项 | 1、该细胞推荐使用Leibovitz's L-15培养基进行培养,Leibovitz's L-15不可以通入二氧化碳,会产生细胞毒性; 2、如您没有无二氧化碳的培养箱,可使用DMEM替代Leibovitz's L-15,使用DMEM培养基时即可正常通入5%二氧化碳; 2、配套专用培养基默认Leibovitz's L-15配置,如需DMEM配方,请联系销售下单备注更改。 |
背景描述 | MDA-MB-231来自患有转移乳腺腺癌的51岁女病人的胸水。 在裸鼠和ALS处理的BALB/c小鼠中,它能形成低分化腺癌(III级)。细胞表达WNT7B癌基因。 |
年龄(性别) | 女性,51岁 |
组织来源 | 乳腺腺癌,转移性胸膜渗出液 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 乳腺癌细胞 |
生物安全等级 | BSL-1 |
倍增时间 | ~32-42小时 |
致瘤性 | Yes, in ALS treated BALB/c mice, forms poorly differentiated adenocarcinoma (grade III).Yes, in nude mice, forms poorly differentiated adenocarcinoma (grade III). |
受体表达情况 | epidermal growth factor (EGF), expressed;transforming growth factor alpha (TGF alpha), expressed |
保藏机构 | ATCC; CRL-12532ATCC; HTB-26 ATCC; CRM-HTB-26 BCRC; 60425 BCRJ; 0164 DSMZ; ACC-732 ECACC; 92020424 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12,13 D2S1338 20,21 D3S1358 16 D5S818 12 D7S820 8,9 D8S1179 13 D13S317 13 D16S539 12 D18S51 11,16 D19S433 11,14 D21S11 33.2,33.2 FGA 22,23 PentaD 11,14 PentaE 11 TH01 7,9.3 TPOX 8,9 vWA 15,18 D6S1043 18 D12S391 17,18 D2S441 14,15 -
STR鉴定图
参考文献
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miR-29b-3p promotes progression of MDA-MB-231 triple-negative breast cancer cells through downregulating TRAF3(2019/7/26)
作者:Bao Zhang, Shetti, Dattatrya
期刊:Biological Research
影响因子 :6.700
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A universal strategy of glyconanoparticle preparation using a bifunctional linker for lectin sensing and cell imaging(2022/03/25)
作者:Qiuyue Sha, Jian Fei, Chang Tu
期刊:Microchimica Acta
DOI:10.1007/s00604-022-05220-w
影响因子 :5.700
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Orosomucoid 1 promotes epirubicin resistance in breast cancer by upregulating the expression of matrix metalloproteinases 2 and 9(2021/9/24)
作者:Luo Qiong, Jun Yin
期刊:Bioengineered
DOI:10.1080/21655979.2021.1987067
影响因子 :4.900
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Knockdown of circular RNA septin 9 inhibits the malignant progression of breast cancer by reducing the expression of solute carrier family 1 member 5 in a microRNA-149-5p-dependent manner(2021/10/27)
作者:Jianjun Wang, Kunxian Yang, Junyu Cao
期刊:Bioengineered
DOI:10.1080/21655979.2021.2000731
影响因子 :4.900
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4-Amino-2-trifluoromethyl-phenyl retinate inhibits proliferation, invasion, and migration of breast cancer cells by independently regulating CRABP2 and FABP5(2018/04/27)
作者:Jing Ju, Nan Wang, Jiali Wang
期刊:Drug Design Development and Therapy
影响因子 :4.319
引用产品:CL-0150
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Tumor-promoting mechanisms of macrophage-derived extracellular vesicles-enclosed microRNA-660 in breast cancer progression(2022/01/27)
作者:Changchun Li, Ruiqing Li, Xingchi Hu
期刊:Breast Cancer Research And Treatment
DOI:10.1007/s10549-021-06433-y
影响因子 :3.800
引用产品:CL-0150
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Silence of α1-Antitrypsin Inhibits Migration and Proliferation of Triple Negative Breast Cancer Cells(2018/09/27)
作者:Zhijing Zhao, Junfeng Ma, Ying Mao
期刊:Medical Science Monitor
影响因子 :3.100
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Identification of novel topoisomerase II alpha inhibitors by virtual screening, molecular docking, and bioassay(2021/7/21)
作者:Che Yu, Jiabao Hu, Walter Luyten
期刊:Chemical Biology & Drug Design
影响因子 :3.000
引用产品:CL-0150
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Inhibition of glycolysis represses the growth and alleviates the endoplasmic reticulum stress of breast cancer cells by regulating TMTC3(2023/04/10)
作者:Xue Hu, Baoliang Guo, Tong Sun
期刊:Open Medicine
影响因子 :2.100
引用产品:164210 164215 CL-0149 CL-0150 CL-0211 CL-0525 PB180120 PB180424 PM150140 PM150312 PM150710 PM151010
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Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell(2019/8/14)
作者:Mingjiang Yao, Xiaodi Fan, Bo Yuan
期刊:BMC Complementary and Alternative Medicine
影响因子 :0.000
引用产品:CL-0150