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产品概述
名称 | LX-2 (人肝星形细胞) (STR鉴定正确) |
别称 | Lieming Xu-2 |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 上皮细胞样 |
生长培养基 | DMEM+10% FBS+1% P/S |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养条件 | 气相:空气,95%;CO2,5% 温度:37℃ |
推荐传代比例 | 1:2-1:4 |
推荐换液频率 | 2~3次/周 |
细胞类型 | 转化细胞系 |
倍增时间 | ~48-96 hours |
STR鉴定
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STR位点信息
Amelogenin X,Y CSF1PO 10,12 D2S1338 17 D3S1358 13,15 D5S818 11,12 D7S820 11 D8S1179 13 D13S317 11,13 D16S539 13 D18S51 12 D19S433 13,15.2 D21S11 28,31 FGA 21,26 PentaD 12,13,15 PentaE 5,21 TH01 9.3 TPOX 8,9 vWA 17 D6S1043 11,12 D12S391 15,17 D2S441 11,14 -
STR鉴定图
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参考文献
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Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-β pathway(2020/06/05)
作者:Xiaoxue Yang, Liping Ma, Rong Wei
期刊:Signal Transduction and Targeted Therapy
影响因子 :38.104
引用产品:CL-0560
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Single-cell transcriptomic dissection of the cellular and molecular events underlying the triclosan-induced liver fibrosis in mice(2023/02/22)
作者:Yunmeng Bai, Fan Yang, Piao Luo
期刊:Military Medical Research
DOI:10.1186/s40779-023-00441-3
影响因子 :34.9150
引用产品:CL-0560
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HBeAg mediates inflammatory functions of macrophages by TLR2 contributing to hepatic fibrosis(2021/10/15)
作者:Xiaoyu Xie, Huanran Lv, Chenxi Liu
期刊:BMC Medicine
DOI:10.1186/s12916-021-02085-3
影响因子 :11.150
引用产品:CL-0560
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Enhanced glypican-3-targeted identification of hepatocellular carcinoma with liver fibrosis by pre-degrading excess fibrotic collagen(2023/01/02)
作者:Jiaming Zhuo, Yueqi Wang, Hui Hui
期刊:Acta Biomaterialia
DOI:10.1016/j.actbio.2022.12.062
影响因子 :10.6330
引用产品:CL-0560
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Oroxylin A regulates cGAS DNA hypermethylation induced by methionine metabolism to promote HSC senescence(2022/12/02)
作者:Danli Zhao, Yuanyuan Gao, Ying Su
期刊:PHARMACOLOGICAL RESEARCH
DOI:10.1016/j.phrs.2022.106590
影响因子 :10.3340
引用产品:CL-0560
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Fibroblast growth factor 18 attenuates liver fibrosis and HSCs activation via the SMO-LATS1-YAP pathway(2022/02/21)
作者:Gaozan Tong, Xixi Chen, Jongsuk Lee
期刊:Pharmacological Research
DOI:10.1016/j.phrs.2022.106139
影响因子 :10.3340
引用产品:CL-0560
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Circular RNA circPSD3 alleviates hepatic fibrogenesis by regulating the miR-92b-3p/Smad7 axis(2021/01/16)
作者:Fangtian Bu, Yan Zhu, Xin Chen
期刊:Molecular Therapy-Nucleic Acids
DOI:10.1016/j.omtn.2021.01.007
影响因子 :10.183
引用产品:CL-0560
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Rational synthesis of carbon dots with phosphate ester group for direct mapping of endogenous alkaline phosphatase and polarity monitoring in living cells(2023/02/28)
作者:Yanzhi Xing, Yulong Xu, Yanna Lin
期刊:JOURNAL OF COLLOID AND INTERFACE SCIENCE
DOI:10.1016/j.jcis.2023.02.133
影响因子 :9.9650
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MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression(2018/06/18)
作者:Liping Ma, Xiaoxue Yang, Rong We
期刊:Cell Death & Disease
影响因子 :9.685
引用产品:CL-0560
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CK2 blockade alleviates liver fibrosis by suppressing activation of hepatic stellate cells via the Hedgehog pathway(2022/09/07)
作者:Junfu Fan, Gaozan Tong, Xixi Chen
期刊:BRITISH JOURNAL OF PHARMACOLOGY
影响因子 :9.4730
引用产品:CL-0560
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3D hESC exosomes enriched with miR-6766-3p ameliorates liver fibrosis by attenuating activated stellate cells through targeting the TGFβRII-SMADS pathway(2021/12/20)
作者:Ning Wang, Xiajing Li, Zhiyong Zhong
期刊:Journal Of Nanobiotechnology
DOI:10.1186/s12951-021-01138-2
影响因子 :9.4290
引用产品:CL-0560
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Fe (III)@TA@IGF-2 microspheres loaded hydrogel for liver injury treatment(2020/04/28)
作者:Jie Chen, Xicheng Wang, Hua Ye
期刊:International Journal Of Biological Macromolecules
DOI:10.1016/j.ijbiomac.2020.04.206
影响因子 :8.025
引用产品:CL-0560
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Discovery of 4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide derivatives as novel anti-inflammatory agents for the treatment of acute lung injury and sepsis(2023/01/23)
作者:Jun Yang, Minxiu Wang, Yulan Xu
期刊:EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
DOI:10.1016/j.ejmech.2023.115144
影响因子 :7.0880
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Exosomal microRNA-618 derived from mesenchymal stem cells attenuate the progression of hepatic fibrosis by targeting Smad4(2022/02/24)
作者:Chao Sun, Cuicui Shi, Xiaoyan Duan
期刊:Bioengineered
DOI:10.1080/21655979.2021.2023799
影响因子 :6.8320
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Hastatoside attenuates carbon tetrachloride-induced liver fibrosis by targeting glycogen synthase kinase-3β(2022/12/07)
作者:Changlin Du, Jiahui Dong, Qi Wang
期刊:PHYTOMEDICINE
DOI:10.1016/j.phymed.2022.154585
影响因子 :6.6560
引用产品:CL-0560
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Nanodrug rescues liver fibrosis via synergistic therapy with H2O2 depletion and Saikosaponin b1 sustained release(2023/02/16)
作者:Mengyun Peng, Meiyu Shao, Hongyan Dong
期刊:Communications Biology
DOI:10.1038/s42003-023-04473-2
影响因子 :6.5480
引用产品:CL-0560
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Screening of Anti-liver Fibrosis Peptides from Turtle Shell Protein using Two-Enzyme Hydrolysis by Molecular Docking(2022/12/23)
作者:Shufan Xia, Yao Li, Pengtao You
期刊:Food & Function
影响因子 :6.3170
引用产品:CL-0560
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Neddylation of EphB1 Regulates Its Activity and Associates with Liver Fibrosis(2023/02/08)
作者:Rongxin Li, Dan Zhang, Yueqing Han
期刊:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 :6.2080
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BRD4 promotes hepatic stellate cells activation and hepatic fibrosis via mediating P300/H3K27ac/PLK1 axis(2023/03/11)
作者:Miao Cheng, Juanjuan Li, Xueni Niu
期刊:BIOCHEMICAL PHARMACOLOGY
影响因子 :6.1000
引用产品:CL-0560
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CLEC4s as Potential Therapeutic Targets in Hepatocellular Carcinoma Microenvironment(2021/08/02)
作者:Yinjiang Zhang, Hongyun Wei, Lu Fan
期刊:Frontiers in Cell and Developmental Biology
影响因子 :6.081
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Role of PML SUMOylation in arsenic trioxide-induced fibrosis in HSCs(2020/03/30)
作者:Jingyuan Dai, Yunhua Hu, Qiang Niu
期刊:Life Sciences
影响因子 :5.738
引用产品:CL-0560
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Aucubin ameliorates liver fibrosis and hepatic stellate cells activation in diabetic mice via inhibiting ER stress-mediated IRE1α/TXNIP/NLRP3 inflammasome through NOX4/ROS pathway(2022/08/10)
作者:Xiaowen Bao, Jiaqi Li, Chaoxing Ren
期刊:CHEMICO-BIOLOGICAL INTERACTIONS
影响因子 :5.1680
引用产品:CL-0560
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Schisandrin B Attenuates Hepatic Stellate Cell Activation and Promotes Apoptosis to Protect against Liver Fibrosis(2021/11/15)
作者:Zhiman Li, Lijuan Zhao, Yunshi Xia
期刊:Molecules
影响因子 :4.9270
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Long noncoding RNA HULC regulates the NF-κB pathway and represents a promising prognostic biomarker in liver cancer(2022/10/10)
作者:Shihai Liu, Lakshmi Huttad, Guifang He
期刊:Cancer Medicine
影响因子 :4.7110
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Extracellular vesicles derived from cancer-associated fibroblasts carry tumor-promotive microRNA-1228-3p to enhance the resistance of hepatocellular carcinoma cells to sorafenib(2022/11/23)
作者:Zhang, Yijie, Pan, Qi, Shao, Zigong
期刊:Human Cell
DOI:10.1007/s13577-022-00800-7
影响因子 :4.3740
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Doxazosin Attenuates Liver Fibrosis by Inhibiting Autophagy in Hepatic Stellate Cells via Activation of the PI3K/Akt/mTOR Signaling Pathway(2021/08/21)
作者:Aiyuan Xiu, Qian Ding, Zhen Li
期刊:Drug Design Development and Therapy
影响因子 :4.3190
引用产品:CL-0560
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MicroRNA-195-3p promotes hepatic stellate cell activation and liver fibrosis by suppressing PTEN expression(2021/11/25)
作者:Ao Wang, Fangtian Bu, Juanjuan Li
期刊:Toxicology Letters
DOI:10.1016/j.toxlet.2021.11.014
影响因子 :4.2710
引用产品:CL-0560
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PM2.5 promotes Drp1-mediated mitophagy to induce hepatic stellate cell activation and hepatic fibrosis via regulating miR-411(2021/09/08)
作者:Zhongjian Wang, Hui Yu, Jinjin Hao
期刊:Experimental Cell Research
DOI:10.1016/j.yexcr.2021.112828
影响因子 :4.1450
引用产品:CL-0560
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The mechanism and role of intracellular α-ketoglutarate reduction in hepatic stellate cell activation(2020/3/27)
作者:Jianjian Zhao, Yueping Jiang, Xueguo Sun
期刊:Bioscience Reports
影响因子 :3.9760
引用产品:CL-0560
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Structures and In Vitro Antihepatic Fibrosis Activities of Prenylated Dihydrostilbenes and Flavonoids from Glycyrrhiza uralensis Leaves(2019/4/16)
作者:Yuhong Fan, Rigui Ye, Haiyan Xu
期刊:Journal Of Food Science
影响因子 :3.6930
引用产品:CL-0560
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miR221 regulates TGF-β1-induced HSC activation through inhibiting autophagy by directly targeting LAMP2(2021/9/9)
作者:Ran Cheng, Hao Xu, Yang Hong
期刊:Molecular Medicine Reports
影响因子 :3.4230
引用产品:CL-0560
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Antifibrotic effects of specific siRNA targeting connective tissue growth factor delivered by polyethyleneimine‑functionalized magnetic iron oxide nanoparticles on LX‑2 cells(2019/11/20)
作者:Qin Yu, Xiaoqin Xiong, Lei Zhao
期刊:Molecular Medicine Reports
影响因子 :3.4230
引用产品:CL-0560
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Discovery of catalytic-site-fluorescent probes for tracing phosphodiesterase 5 in living cells(2021/10/4)
作者:Meiying Qiu, Deyan Wu, Yiyou Huang
期刊:RSC Advances
影响因子 :3.3610
引用产品:CL-0560
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Filamin A is overexpressed in non-alcoholic steatohepatitis and contributes to the progression of inflammation and fibrosis(2023/02/22)
作者:Ying Lu, Mengzhu Wang, Manyu Zhao
期刊:BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI:10.1016/j.bbrc.2023.02.048
影响因子 :3.3220
引用产品:CL-0560
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Knockdown of TRIM15 inhibits the activation of hepatic stellate cells(2021/6/17)
作者:Junpei Zhang, Yin Chen, Yi Tian
期刊:Journal Of Molecular Histology
DOI:10.1007/s10735-021-09997-7
影响因子 :3.1560
引用产品:CL-0560
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Monocyte-derived immature dendritic cells negatively regulate hepatic stellate cells in vitro by secreting IL-10(2022/12/21)
作者:Yang Xu, Feng Liu, Di He
期刊:IMMUNOBIOLOGY
DOI:10.1016/j.imbio.2022.152315
影响因子 :3.1520
引用产品:CL-0560
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Identification of key genes, pathways and potential therapeutic agents for liver fibrosis using an integrated bioinformatics analysis(2019/3/22)
作者:Zhu Zhan, Yuhe Chen, Yuanqin Duan
期刊:PeerJ
影响因子 :3.0610
引用产品:CL-0560
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Comparative RNA-sequencing profiled the differential gene expression of liver in response to acetyl-CoA carboxylase inhibitor GS-0976 in a mouse model of NASH(2019/12/20)
作者:Ying Lu, Xiaolan Su, Manyu Zhao
期刊:PeerJ
影响因子 :3.0610
引用产品:CL-0560
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Identification of miRNA-target gene regulatory networks in liver fibrosis based on bioinformatics analysis(2021/8/6)
作者:Yang Tai, Chong Zhao, Jinhang Gao
期刊:PeerJ
影响因子 :2.9840
引用产品:CL-0560
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Hyperoside protects against heart failure-induced liver fibrosis in rats(2019/7/26)
作者:Xiao Guoa , Chengzhan Zhub , Xiaojun Liua
期刊:Acta Histochemica
DOI:10.1016/j.acthis.2019.07.005
影响因子 :2.1470
引用产品:CL-0560
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Hsa_circ_0072765 knockdown inhibits proliferation, activation and migration in transforming growth factor-beta (TGF-β)-induced hepatic stellate cells (HSCs) by the miR-197-3p/TRPV3 axis(2023/01/17)
作者:Yan Jin, Xueyan Guo, Rong Zhang
期刊:HISTOLOGY AND HISTOPATHOLOGY
影响因子 :2.1300