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产品概述
| 名称 | MDA-MB-231 (人乳腺癌细胞) (DMEM) (STR鉴定正确) |
| 别称 | MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA231; MB231; MD Anderson-Metastatic Breast-231 |
| 背景描述 | MDA-MB-231来自患有转移乳腺腺癌的51岁女病人的胸水。 在裸鼠和ALS处理的BALB/c小鼠中，它能形成低分化腺癌（III级）。细胞表达WNT7B癌基因。 |
| 种属 | 人 |
| 年龄（性别） | 女性，51岁 |
| 组织来源 | 乳腺腺癌，转移性胸膜渗出液 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 乳腺癌细胞 |
| 生物安全等级 | 1 |
| 生长培养基 | DMEM＋10% FBS＋1% P/S |
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2~3次/周 |
| 倍增时间 | ~32-42小时 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
| 致瘤性 | Yes, in ALS treated BALB/c mice, forms poorly differentiated adenocarcinoma (grade III).Yes, in nude mice, forms poorly differentiated adenocarcinoma (grade III). |
| 受体表达情况 | epidermal growth factor (EGF), expressed;transforming growth factor alpha (TGF alpha), expressed |
| 保藏机构 | ATCC; CRL-12532ATCC; HTB-26 ATCC; CRM-HTB-26 BCRC; 60425 BCRJ; 0164 DSMZ; ACC-732 ECACC; 92020424 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12,13 D2S1338 20,21 D3S1358 16 D5S818 12 D7S820 8,9 D8S1179 13 D13S317 13 D16S539 12 D18S51 11,16 D19S433 11,14 D21S11 30,33.2 FGA 22,23 PentaD 11,14 PentaE 11 TH01 7,9.3 TPOX 8,9 vWA 15,18 D6S1043 18 D12S391 17,18 D2S441 14,15 -
STR鉴定图
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参考文献
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Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase(2021/08/05)
作者：Ximing Shao, Zhihao Ding, Wenhua Zhou
期刊：Nature Nanotechnology
DOI：10.1038/s41565-021-00952-x
影响因子 ：40.523
引用产品：CL-0016 CL-0101 CL-0103 CL-0150A CL-0150B CL-0236 CL-0238
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Mitochondria-targeted magnetic gold nanoheterostructure for multi-modal imaging guided photothermal and photodynamic therapy of triple-negative breast cancer(2020/07/24)
作者：Bo Li, Qian Zhou, Haiyang Wang
期刊：Chemical Engineering Journal
影响因子 ：16.744
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Developing a Versatile Multiscale Therapeutic Platform for Osteosarcoma Synergistic Photothermo-Chemotherapy with Effective Osteogenicity and Antibacterial Capability(2022/09/20)
作者：Yunlong Ma, Lan Jiang, Jie Hu
期刊：ACS Applied Materials & Interfaces
影响因子 ：10.3830
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MoS2 Quantum Dot@Polyaniline Inorganic–Organic Nanohybrids for in Vivo Dual-Modal Imaging Guided Synergistic Photothermal/Radiation Therapy(2016/09/07)
作者：Jinping Wang, Xiaoxiao Tan, Xiaojuan Pang
期刊：ACS Applied Materials & Interfaces
影响因子 ：10.3830
引用产品：CL-0016 CL-0101 CL-0103 CL-0150A CL-0150B CL-0236 CL-0238
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Targeting visualization of malignant tumor based on the alteration of DWI signal generated by hTERT promoter–driven AQP1 overexpression(2022/01/19)
作者：Liang Zhang, Mingfu Gong, Sheng Lei
期刊：European Journal Of Nuclear Medicine And Molecular Imaging
DOI：10.1007/s00259-022-05684-1
影响因子 ：10.0570
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Phenotype-related drug sensitivity analysis of single CTCs for medicine evaluation(2020/08/10)
作者：Haimeng Pei, Mei Yu, Defang Dong
期刊：Chemical Science
影响因子 ：9.969
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Up-regulated circBACH2 contributes to cell proliferation, invasion, and migration of triple-negative breast cancer(2021/4/19)
作者：Xinxing Wang, Bingjian Xue, Yujie Zhang
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-03684-x
影响因子 ：9.685
引用产品：CL-0040 CL-0041 CL-0149 CL-0150A CL-0150B CL-0152A CL-0152B CL-0290A CL-0290B CL-0525
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MCPIP1-mediated NFIC alternative splicing inhibits proliferation of triple-negative breast cancer via cyclin D1-Rb-E2F1 axis(2021/04/06)
作者：Fengxia Chen, Qingqing Wang, Xiaoyan Yu
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-03661-4
影响因子 ：9.685
引用产品：CL-0005 CL-0041 CL-0114 CL-0150A CL-0150B CL-0380 CL-0525 PM150312B
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Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer(2022/09/02)
作者：Xinchen Jiang, Fanghai Tu, Liyuan Wei
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.2c01058
影响因子 ：8.0390
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Design, Synthesis, and Evaluation of New Sugar-Substituted Imidazole Derivatives as Selective c-MYC Transcription Repressors Targeting the Promoter G-Quadruplex(2022/09/19)
作者：Maolin Li, Jingmei Yuan, Hao Yuan
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.2c00467
影响因子 ：8.0390
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Simultaneous Fluorescence Visualization of Epithelial-Mesenchymal Transition and Apoptosis Processes in Tumor Cells for Evaluating the Impact of Epithelial-Mesenchymal Transition on Drug Efficacy(2018/09/18)
作者：Mingming Luan, Jinjie Chang, Wei Pan
期刊：Anal Chem
DOI：10.1021/acs.analchem.8b02494
影响因子 ：8.008
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A self-assembled RNA-triple helix hydrogel drug delivery system targeting triple-negative breast cancer(2019/11/08)
作者：Lairong Ding, Junwei Li, Changrong Wu
期刊：Journal of Materials Chemistry B
影响因子 ：7.571
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Assessment of 2-allyl-4,5-dimethoxyphenol safety and attractiveness to mature males of Bactrocera dorsalis (Hendel)(2021/08/04)
作者：Shuzhen Deng, Xinyang Li, Ziming Wang
期刊：Ecotoxicology And Environmental Safety
DOI：10.1016/j.ecoenv.2021.112567
影响因子 ：7.129
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A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy(2021/03/23)
作者：Hairong Wang, Yawen Zhang, Xiangle Zeng
期刊：International Journal of Nanomedicine
影响因子 ：7.0330
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Therapeutic Effect of Doxorubicin-Chlorin E6-Loaded Mesoporous Silica Nanoparticles Combined with Ultrasound on Triple-Negative Breast Cancer(2020/04/21)
作者：Peng Xu, Jia Yao, Zhen Li
期刊：International Journal of Nanomedicine
影响因子 ：7.0330
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The role of microRNA-4723-5p regulated by c-myc in triple-negative breast cancer(2022/04/06)
作者：Xixin Jin, Chao Gao, Wenxin Wei
期刊：Bioengineered
DOI：10.1080/21655979.2022.2056824
影响因子 ：6.8320
引用产品：CL-0150B
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Weighted gene correlation network analysis identifies RSAD2, HERC5, and CCL8 as prognostic candidates for breast cancer(2019/06/21)
作者：Jianing Tang, Qian Yang, Qiuxia Cui
期刊：Journal Of Cellular Physiology
影响因子 ：6.513
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Co-delivery of epirubicin and paclitaxel using an estrone-targeted PEGylated liposomal nanoparticle for breast cancer(2020/01/05)
作者：Huan Tang, Jinglin Chen, Lin Wang
期刊：International Journal of Pharmaceutics
DOI：10.1016/j.ijpharm.2019.118806
影响因子 ：6.510
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Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway(2019/10/07)
作者：Tianqi Li, Yudi Xiong, Qingqing Wang
期刊：Artificial Cells Nanomedicine and Biotechnology
DOI：10.1080/21691401.2019.1670670
影响因子 ：6.355
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LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instability(2021/11/05)
作者：Pengping Li, Rongguo Li, Yuqing Huang
期刊：Aging-US
影响因子 ：5.9550
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Enzymatic rhamnosylation of anticancer drugs by an α-l-rhamnosidase from Alternaria sp. L1 for cancer-targeting and enzyme-activated prodrug therapy(2019/08/08)
作者：Li Xu , Xiaohong Liu , Yinping Li
期刊：Applied Microbiology And Biotechnology
DOI：10.1007/s00253-019-10011-0
影响因子 ：5.560
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Structures and antitumor activities of ten new and twenty known surfactins from the deep-sea bacterium Limimaricola sp. SCSIO 53532( 2021/12/31)
作者：Wenping Ding, Yanqun Li, Min Chen
期刊： BIOORGANIC CHEMISTRY
DOI：10.1016/j.bioorg.2021.105589
影响因子 ：5.3070
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Ferroptosis regulators, especially SQLE, play an important role in prognosis, progression and immune environment of breast cancer(2021/10/29)
作者：Wenqing Tang, Fangshi Xu, Meng Zhao
期刊：Bmc Cancer
DOI：10.1186/s12885-021-08892-4
影响因子 ：4.638
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Assessment of attractancy and safeness of (E)-coniferyl alcohol for management of female adults of Oriental fruit fly, Bactrocera dorsalis (Hendel)(2021/11/23)
作者：Huan Liu, Dandan Wang, Lin Wan
期刊：Pest Management Science
DOI：10.1002/ps.6713
影响因子 ：4.4620
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Possible involvement of TGF‑β‑SMAD‑mediated epithelial‑mesenchymal transition in pro‑metastatic property of PAX6(2020/06/11)
作者：Meng Jin, Daili Gao, Rongchun Wang
期刊：Oncology Reports
影响因子 ：4.136
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Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell(2019/08/14)
作者：Mingjiang Yao, Xiaodi Fan, Bo Yuan
期刊：BMC Complementary and Alternative Medicine volume
影响因子 ：3.6590
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Exploration of Clove Bud (Syzygium aromaticum) Essential Oil as a Novel Attractant against Bactrocera dorsalis (Hendel) and Its Safety Evaluation(2022/10/09)
作者：Zhenjie Hu, Jingwei Yang, Zihan Chen
期刊：Insects
影响因子 ：3.1390
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Deciphering the map of METTL14-mediated lncRNA m6A modification at the transcriptome-wide level in breast cancer(2022/11/06)
作者：Dandan Yi, Fazhan Xu, Ru Wang, Chaoyu Jiang, Jiabo Qin, YiHsuan Lee, Xianbiao Shi, Jianfeng Sang
期刊：JOURNAL OF CLINICAL LABORATORY ANALYSIS
影响因子 ：3.1240
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Overexpression of HOXD8 inhibits the proliferation, migration and invasion of breast cancer cells by downregulating ILP2 expression(2021/7/15)
作者：Xiaoyun Wen,Yu Chen, Xiansong Fang
期刊：Experimental and Therapeutic Medicine
影响因子 ：2.7510
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The Antitumor Potential of Extract of the Oak Bracket Medicinal Mushroom Inonotus baumii in SMMC-7721 Tumor Cells(2019/09/22)
作者：Yue Yang, Pingya He
期刊：Evidence-Based Complementary and Alternative Medicine
影响因子 ：2.650
