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产品概述
| 名称 | MDA-MB-231 (人乳腺癌细胞) (DMEM) (STR鉴定正确) |
| 别称 | MDA-MB 231; MDA.MB.231; MDA MB 231; MDA MB231; MDA Mb231; MDA-MB231; MDAMB-231; MDAMB231; MDA-231; MDA231; MB231; MD Anderson-Metastatic Breast-231 |
| 种属 | 人 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 生长培养基 | DMEM＋10% FBS＋1% P/S |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2~3次/周 |
| 背景描述 | MDA-MB-231来自患有转移乳腺腺癌的51岁女病人的胸水。 在裸鼠和ALS处理的BALB/c小鼠中，它能形成低分化腺癌（III级）。细胞表达WNT7B癌基因。 |
| 年龄（性别） | 女性，51岁 |
| 组织来源 | 乳腺腺癌，转移性胸膜渗出液 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 乳腺癌细胞 |
| 生物安全等级 | 1 |
| 倍增时间 | ~32-42小时 |
| 致瘤性 | Yes, in ALS treated BALB/c mice, forms poorly differentiated adenocarcinoma (grade III).Yes, in nude mice, forms poorly differentiated adenocarcinoma (grade III). |
| 受体表达情况 | epidermal growth factor (EGF), expressed;transforming growth factor alpha (TGF alpha), expressed |
| 保藏机构 | ATCC; CRL-12532ATCC; HTB-26 ATCC; CRM-HTB-26 BCRC; 60425 BCRJ; 0164 DSMZ; ACC-732 ECACC; 92020424 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 12,13 D2S1338 20,21 D3S1358 16 D5S818 12 D7S820 8,9 D8S1179 13 D13S317 13 D16S539 12 D18S51 11,16 D19S433 11,14 D21S11 30,33.2 FGA 22,23 PentaD 11,14 PentaE 11 TH01 7,9.3 TPOX 8,9 vWA 15,18 D6S1043 18 D12S391 17,18 D2S441 14,15 -
STR鉴定图
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参考文献
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Intrinsic bioactivity of black phosphorus nanomaterials on mitotic centrosome destabilization through suppression of PLK1 kinase(2021/08/05)
作者：Ximing Shao, Zhihao Ding, Wenhua Zhou
期刊：Nature Nanotechnology
DOI：10.1038/s41565-021-00952-x
影响因子 ：38.300
引用产品：CL-0016 CL-0101 CL-0103 CL-0150A CL-0150B CL-0236 CL-0238
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Mitochondria-targeted magnetic gold nanoheterostructure for multi-modal imaging guided photothermal and photodynamic therapy of triple-negative breast cancer(2020/07/24)
作者：Bo Li, Qian Zhou, Haiyang Wang
期刊：Chemical Engineering Journal
影响因子 ：15.100
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Developing a Versatile Multiscale Therapeutic Platform for Osteosarcoma Synergistic Photothermo-Chemotherapy with Effective Osteogenicity and Antibacterial Capability(2022/09/20)
作者：Yunlong Ma, Lan Jiang, Jie Hu
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.500
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Targeting visualization of malignant tumor based on the alteration of DWI signal generated by hTERT promoter–driven AQP1 overexpression(2022/01/19)
作者：Liang Zhang, Mingfu Gong, Sheng Lei
期刊：European Journal Of Nuclear Medicine And Molecular Imaging
DOI：10.1007/s00259-022-05684-1
影响因子 ：9.100
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Up-regulated circBACH2 contributes to cell proliferation, invasion, and migration of triple-negative breast cancer(2021/4/19)
作者：Xinxing Wang, Bingjian Xue, Yujie Zhang
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-03684-x
影响因子 ：9.000
引用产品：CL-0040 CL-0041 CL-0149 CL-0150A CL-0150B CL-0152A CL-0152B CL-0290A CL-0290B CL-0525
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MCPIP1-mediated NFIC alternative splicing inhibits proliferation of triple-negative breast cancer via cyclin D1-Rb-E2F1 axis(2021/04/06)
作者：Fengxia Chen, Qingqing Wang, Xiaoyan Yu
期刊：Cell Death & Disease
DOI：10.1038/s41419-021-03661-4
影响因子 ：9.000
引用产品：CL-0005 CL-0041 CL-0114 CL-0150A CL-0150B CL-0380 CL-0525 PM150312B
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Phenotype-related drug sensitivity analysis of single CTCs for medicine evaluation(2020/08/10)
作者：Haimeng Pei, Mei Yu, Defang Dong
期刊：Chemical Science
影响因子 ：8.400
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A truncated DNA aptamer with high selectivity for estrogen receptor-positive breast cancer cells(2023/08/25)
作者：Ying Cong, Shuyue Zhang, Hongmei Li
期刊：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
DOI：10.1016/j.ijbiomac.2023.126450
影响因子 ：8.200
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A Combined Self-Assembled Drug Delivery for Effective Anti-Breast Cancer Therapy(2021/03/23)
作者：Hairong Wang, Yawen Zhang, Xiangle Zeng
期刊：International Journal of Nanomedicine
影响因子 ：8.000
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Therapeutic Effect of Doxorubicin-Chlorin E6-Loaded Mesoporous Silica Nanoparticles Combined with Ultrasound on Triple-Negative Breast Cancer(2020/04/21)
作者：Peng Xu, Jia Yao, Zhen Li
期刊：International Journal of Nanomedicine
影响因子 ：8.000
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A self-assembled RNA-triple helix hydrogel drug delivery system targeting triple-negative breast cancer(2019/11/08)
作者：Lairong Ding, Junwei Li, Changrong Wu
期刊：Journal of Materials Chemistry B
影响因子 ：7.571
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Simultaneous Fluorescence Visualization of Epithelial-Mesenchymal Transition and Apoptosis Processes in Tumor Cells for Evaluating the Impact of Epithelial-Mesenchymal Transition on Drug Efficacy(2018/09/18)
作者：Mingming Luan, Jinjie Chang, Wei Pan
期刊：Analytical Chemistry
DOI：10.1021/acs.analchem.8b02494
影响因子 ：7.400
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Combined Molecular and Morphological Imaging of CTCs for HER2-Targeted Chemotherapy Guidance(2023/08/22)
作者：Haimeng Pei, Zhaojun Han, Dexin Du
期刊：ANALYTICAL CHEMISTRY
DOI：10.1021/acs.analchem.3c02333
影响因子 ：7.400
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Discovery of a Novel G-Quadruplex and Histone Deacetylase (HDAC) Dual-Targeting Agent for the Treatment of Triple-Negative Breast Cancer(2022/09/02)
作者：Xinchen Jiang, Fanghai Tu, Liyuan Wei
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.2c01058
影响因子 ：7.300
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Design, Synthesis, and Evaluation of New Sugar-Substituted Imidazole Derivatives as Selective c-MYC Transcription Repressors Targeting the Promoter G-Quadruplex(2022/09/19)
作者：Maolin Li, Jingmei Yuan, Hao Yuan
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.2c00467
影响因子 ：7.300
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Design, Synthesis, and Biological Evaluation of Proteolysis-Targeting Chimeras as Highly Selective and Efficient Degraders of Extracellular Signal-Regulated Kinase 5(2023/09/26)
作者：Pengming Pan, Tongtong Geng, Zhongtang Li
期刊：JOURNAL OF MEDICINAL CHEMISTRY
DOI：10.1021/acs.jmedchem.3c00864
影响因子 ：7.300
引用产品：CL-0014 CL-0096 CL-0103 CL-0150B CL-0185 CL-0233 CL-0298
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Assessment of 2-allyl-4,5-dimethoxyphenol safety and attractiveness to mature males of Bactrocera dorsalis (Hendel)(2021/08/04)
作者：Shuzhen Deng, Xinyang Li, Ziming Wang
期刊：Ecotoxicology And Environmental Safety
DOI：10.1016/j.ecoenv.2021.112567
影响因子 ：6.800
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Low-dose phthalates promote breast cancer stem cell properties via the oncogene ΔNp63α and the Sonic hedgehog pathway(2023/02/06)
作者：Wanshuang Cao, Mengjiu Zhao, Yue Chen
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2023.114605
影响因子 ：6.800
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Metabolome Sequencing Reveals that Protein Arginine-N-Methyltransferase 1 Promotes the Progression of Invasive Micropapillary Carcinoma of the Breast and Predicts a Poor Prognosis(2023/06/09)
作者：Kailiang Wu, Weidong Li, Hanjiao Liu
期刊：AMERICAN JOURNAL OF PATHOLOGY
DOI：10.1016/j.ajpath.2023.05.010
影响因子 ：6.000
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Ribociclib (LEE011) suppresses cell proliferation and induces apoptosis of MDA-MB-231 by inhibiting CDK4/6-cyclin D-Rb-E2F pathway(2019/10/07)
作者：Tianqi Li, Yudi Xiong, Qingqing Wang
期刊：Artificial Cells Nanomedicine and Biotechnology
DOI：10.1080/21691401.2019.1670670
影响因子 ：5.800
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Co-delivery of epirubicin and paclitaxel using an estrone-targeted PEGylated liposomal nanoparticle for breast cancer(2020/01/05)
作者：Huan Tang, Jinglin Chen, Lin Wang
期刊：International Journal of Pharmaceutics
DOI：10.1016/j.ijpharm.2019.118806
影响因子 ：5.800
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Spider venom-derived peptide JZTX-14 prevents migration and invasion of breast cancer cells via inhibition of sodium channels(2023/03/23)
作者：Wenfang Wu, Yuan Yin, Peihao Feng
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2023.1067665
影响因子 ：5.600
引用产品：CL-0150B
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Weighted gene correlation network analysis identifies RSAD2, HERC5, and CCL8 as prognostic candidates for breast cancer(2019/06/21)
作者：Jianing Tang, Qian Yang, Qiuxia Cui
期刊：Journal Of Cellular Physiology
影响因子 ：5.600
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Peficitinib ameliorates doxorubicin-induced cardiotoxicity by suppressing cellular senescence and enhances its antitumor activity(2023/07/12)
作者：Hui Hua, Qi Zhao, Jing Xia
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.110630
影响因子 ：5.600
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Luteolin inhibits triple-negative breast cancer by inducing apoptosis and autophagy through SGK1-FOXO3a-BNIP3 signaling(2023/06/06)
作者：Ling Wu, Yingda Lin, Songyu Gao
期刊：Frontiers in Pharmacology
DOI：10.3389/fphar.2023.1200843
影响因子 ：5.600
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OBHS Drives Abnormal Glycometabolis Reprogramming via GLUT1 in Breast Cancer(2023/04/12)
作者：Kexin Wang, Qiuzi Li, Yufeng Fan
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：5.600
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DEPDC1B-mediated USP5 deubiquitination of β-catenin promotes breast cancer metastasis by activating the wnt/β-catenin pathway(2023/08/29)
作者：Qingqing Wang, Fengxia Chen, Ningning Yang
期刊：AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
DOI：10.1152/ajpcell.00249.2023
影响因子 ：5.500
引用产品：CL-0001 CL-0041 CL-0150B CL-0290B CL-0380 CM-0114 PM150312
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Jiawei Yanghe Decoction suppresses breast cancer by regulating immune responses via JAK2/STAT3 signaling pathway(2023/03/17)
作者：Yanting You, Xiaomei Chen, Xiaohu Chen
期刊：JOURNAL OF ETHNOPHARMACOLOGY
影响因子 ：5.400
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Structurally Diverse Diterpenes from the South China Sea Soft Coral Sarcophyton trocheliophorum(2023/01/20)
作者：Yuting Song, Dandan Yu, Mingzhi Su
期刊：Marine Drugs
影响因子 ：5.400
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Development of anti-breast cancer PI3K inhibitors based on 7-azaindole derivatives through scaffold hopping: Design, synthesis and in vitro biological evaluation(2021/10/ 6)
作者：Chengbin Yang, Mingzhu Lu, Yi Chen
期刊：Bioorganic Chemistry
DOI：10.1016/j.bioorg.2021.105405
影响因子 ：5.307
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LncRNA OTUD6B-AS1 promotes paclitaxel resistance in triple negative breast cancer by regulation of miR-26a-5p/MTDH pathway-mediated autophagy and genomic instability(2021/11/05)
作者：Pengping Li, Rongguo Li, Yuqing Huang
期刊：Aging-US
影响因子 ：5.200
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Exploration of epithelial-mesenchymal transition-related lncRNA signature and drug sensitivity in breast cancer(2023/07/19)
作者：Chengxin Li, Lewei Zheng, Gaoran Xu
期刊：Frontiers in Endocrinology
DOI：10.3389/fendo.2023.1154741
影响因子 ：5.200
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Structures and antitumor activities of ten new and twenty known surfactins from the deep-sea bacterium Limimaricola sp. SCSIO 53532( 2021/12/31)
作者：Wenping Ding, Yanqun Li, Min Chen
期刊： BIOORGANIC CHEMISTRY
DOI：10.1016/j.bioorg.2021.105589
影响因子 ：5.100
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Enzymatic rhamnosylation of anticancer drugs by an α-l-rhamnosidase from Alternaria sp. L1 for cancer-targeting and enzyme-activated prodrug therapy(2019/08/08)
作者：Li Xu , Xiaohong Liu , Yinping Li
期刊：Applied Microbiology And Biotechnology
DOI：10.1007/s00253-019-10011-0
影响因子 ：5.000
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Nanoparticles for co-delivery of paclitaxel and curcumin to overcome chemoresistance against breast cancer(2022/12/01)
作者：Xiangping Lin, Qun Wang, Shuang Du
期刊：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
DOI：10.1016/j.jddst.2022.104050
影响因子 ：5.000
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The role of microRNA-4723-5p regulated by c-myc in triple-negative breast cancer(2022/04/06)
作者：Xixin Jin, Chao Gao, Wenxin Wei
期刊：Bioengineered
DOI：10.1080/21655979.2022.2056824
影响因子 ：4.900
引用产品：CL-0150B
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Possible involvement of TGF‑β‑SMAD‑mediated epithelial‑mesenchymal transition in pro‑metastatic property of PAX6(2020/06/11)
作者：Meng Jin, Daili Gao, Rongchun Wang
期刊：Oncology Reports
影响因子 ：4.200
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Site-directed Late-Stage Diversification of Macrocyclic Nannocystins Facilitating Anticancer SAR and Mode of Action Studies(2022/12/22)
作者：Han Zhang, Yunfeng Tian, Xiaoya Yuan
期刊：RSC Medicinal Chemistry
影响因子 ：4.100
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Assessment of attractancy and safeness of (E)-coniferyl alcohol for management of female adults of Oriental fruit fly, Bactrocera dorsalis (Hendel)(2021/11/23)
作者：Huan Liu, Dandan Wang, Lin Wan
期刊：Pest Management Science
DOI：10.1002/ps.6713
影响因子 ：4.100
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Development of the expression and prognostic significance of m5C-related LncRNAs in breast cancer(2022/12/04)
作者：Gaoran Xu, Chengxin Li, Ziyang Di
期刊：Cancer Medicine
影响因子 ：4.000
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Berberine inhibits NLRP3 Inflammasome pathway in human triple-negative breast cancer MDA-MB-231 cell(2019/08/14)
作者：Mingjiang Yao, Xiaodi Fan, Bo Yuan
期刊：BMC Complementary and Alternative Medicine volume
影响因子 ：3.900
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Ferroptosis regulators, especially SQLE, play an important role in prognosis, progression and immune environment of breast cancer(2021/10/29)
作者：Wenqing Tang, Fangshi Xu, Meng Zhao
期刊：Bmc Cancer
DOI：10.1186/s12885-021-08892-4
影响因子 ：3.800
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Isopimaric acid, an ion channel regulator, regulates calcium and oxidative phosphorylation pathways to inhibit breast cancer proliferation and metastasis(2023/02/06)
作者：Jiacheng Li, Xiaozhen Liu, Lin Chen
期刊：TOXICOLOGY AND APPLIED PHARMACOLOGY
DOI：10.1016/j.taap.2023.116415
影响因子 ：3.800
引用产品：CL-0007 CL-0093 CL-0149 CL-0150B CL-0152B CL-0525 P-CA-201
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A novel disulfidptosis-associated expression pattern in breast cancer based on machine learning(2023/06/29)
作者：Zhitang Wang, Xianqiang Du, Weibin Lian
期刊：Frontiers in Genetics
DOI：10.3389/fgene.2023.1193944
影响因子 ：3.700
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Role of PAX2 in breast cancer verified by bioinformatics analysis and in vitro validation(2023/01/31)
作者：Shan Yang, Wei Gao, Haoqi Wang
期刊：Annals of Translational Medicine
影响因子 ：3.616
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Disulfiram/Copper Induce Ferroptosis in Triple-Negative Breast Cancer Cell Line MDA-MB-231(2023/08/28)
作者：Meiran Chu, Xinglan An, Cong Fu
期刊：Frontiers in Bioscience-Landmark
影响因子 ：3.100
引用产品：CL-0150B
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Exploration of Clove Bud (Syzygium aromaticum) Essential Oil as a Novel Attractant against Bactrocera dorsalis (Hendel) and Its Safety Evaluation(2022/10/09)
作者：Zhenjie Hu, Jingwei Yang, Zihan Chen
期刊：Insects
影响因子 ：3.000
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Anti-tumor cembrane diterpenoids from the South China Sea soft coral Lobophytum sp.(2023/02/28)
作者：Fan Yang, Yuting Song, Dandan Yu
期刊：CHEMISTRY & BIODIVERSITY
影响因子 ：2.900
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Deciphering the map of METTL14-mediated lncRNA m6A modification at the transcriptome-wide level in breast cancer(2022/11/06)
作者：Dandan Yi, Fazhan Xu, Ru Wang, Chaoyu Jiang, Jiabo Qin, YiHsuan Lee, Xianbiao Shi, Jianfeng Sang
期刊：JOURNAL OF CLINICAL LABORATORY ANALYSIS
影响因子 ：2.700
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Identification of PIMREG as a novel prognostic signature in breast cancer via integrated bioinformatics analysis and experimental validation(2023/07/17)
作者：Wenjing Zhao, Yuanjin Chang, Zhaoye Wu
期刊：PeerJ
影响因子 ：2.700
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Overexpression of HOXD8 inhibits the proliferation, migration and invasion of breast cancer cells by downregulating ILP2 expression(2021/7/15)
作者：Xiaoyun Wen,Yu Chen, Xiansong Fang
期刊：Experimental and Therapeutic Medicine
影响因子 ：2.700
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The Antitumor Potential of Extract of the Oak Bracket Medicinal Mushroom Inonotus baumii in SMMC-7721 Tumor Cells(2019/09/22)
作者：Yue Yang, Pingya He
期刊：Evidence-Based Complementary and Alternative Medicine
影响因子 ：2.650
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The diagnostic or prognostic values of FADD in cancers based on pan‑cancer analysis(2023/09/11)
作者：Chenyu Wang, Xianglai Jiang, Qiqi Zhao
期刊：Biomedical Reports
影响因子 ：2.300
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FEZF2 inhibits the growth of triple-negative breast cancer cells through EZH2/PD-L1 and enhances anti-tumor immunity in vivo(2023/06/19)
作者：Wenyu Li, Hu Liu, Wenjuan Li
期刊：Molecular & Cellular Toxicology
DOI：10.1007/s13273-023-00368-9
影响因子 ：1.700
引用产品：164215 CL-0041 CL-0150B CL-0290B CL-0383B CL-0525 PB180120 PM150110 PM150210 PM150312
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Role of hypoxia-inducible factor-1α and survivin in enhancing radiosensitivity of breast cancer(2023/01/28)
作者：Qian Cao, Wenting Xu, Xiuqing Ai
期刊：Journal of Radiation Research and Applied Sciences
DOI：10.1016/j.jrras.2023.100530
影响因子 ：1.600
引用产品：CL-0150B
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In vitro study of piwi interaction RNA-31106 promoting breast carcinogenesis by regulating METTL3-mediated m6A RNA methylation(2023/06/30)
作者：Shengchao Huang, Baoying Chen, Pu Qiu
期刊：Translational Cancer Research
影响因子 ：0.900
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Sanggenon C inhibits proliferation of breast cancer cells and reduces HIF-1α/VEGF pathway activity under hypoxia conditions(2023/09/15)
作者：Junyuan Qu, Jing Li, Yongqiang Ma
期刊：TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
影响因子 ：0.600
![HT-1080 [HT1080] (人纤维肉瘤细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0117-1.jpg)
