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| 名称 | PC-12(High differentiation) (大鼠肾上腺嗜铬细胞瘤细胞(高分化)) (种属鉴定正确) |
| 种属 | 大鼠 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 多角形 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
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| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 1.Undifferentiated、Low differentiation和High differentiation的区别：Undifferentiated的PC-12从形态上看是圆形的，聚团生长的漂浮细胞；Low differentiation的成多角形，有较短的突起；High differentiation的细胞有多个突起，突起数目不等，突触较长，类似神经元轴突。2.Low differentiation和High differentiation是在Undifferentiated的PC-12基础上诱导产生的，Low differentiation和High differentiation指的与神经细胞表型的相似程度，High differentiation更接近神经细胞表型。 |
| 背景描述 | PC-12(High differentiation)细胞是来自能移植的雄性大鼠肾上腺嗜铬细胞瘤。 PC-12(High differentiation)细胞表达神经生长因子(NGF)受体，NGF可诱导产生神经表型。 PC-12(High differentiation)细胞不合成肾上腺素。 |
| 年龄（性别） | 雄性 |
| 组织来源 | 肾上腺嗜铬细胞瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 嗜铬细胞瘤细胞 |
种属鉴定
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种属鉴定图
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参考文献
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Dual-bionic regenerative microenvironment for peripheral nerve repair(2023/03/16)
作者：Yanjun Guan, Zhiqi Ren, Boyao Yang
期刊：Bioactive Materials
DOI：10.1016/j.bioactmat.2023.02.002
影响因子 ：18.900
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Cichoric acid from witloof inhibit misfolding aggregation and fibrillation of hIAPP(2019/11/20)
作者：Zhuoying Luo, Guanbin Gao, Zhongjie Ma
期刊：International Journal Of Biological Macromolecules
DOI：10.1016/j.ijbiomac.2019.10.100
影响因子 ：8.200
引用产品：CL-0481
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Nano-integrated Cascade Antioxidase Opsonized by Albumin Bypass the Blood-Brain Barrier for Ischemia-Reperfusion Injury(2022/10/17)
作者：Wuxuan Wang, Zheng Zhang, Yi Liu
期刊：Biomaterials Science
影响因子 ：6.600
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Astragaloside IV attenuates cerebral ischemia‑reperfusion injury in rats through the inhibition of calcium‑sensing receptor‑mediated apoptosis(2020/11/2)
作者：Shujin Du, Ying Zhang, Yanmeng Zhao
期刊：International Journal Of Molecular Medicine
影响因子 ：5.400
引用产品：CL-0481
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ADMSC Exo-MicroRNA-22 improve neurological function and neuroinflammation in mice with Alzheimers disease(2021/07/26)
作者：Liping Zhai, Heping Shen, Yongjia Sheng
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.300
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NMN Alleviates NP-Induced Learning and Memory Impairment Through SIRT1 Pathway in PC-12 Cell(2023/02/06)
作者：Zhongyi Li, Huan Liu, Wenna Han
期刊：MOLECULAR NEUROBIOLOGY
DOI：10.1007/s12035-023-03251-9
影响因子 ：5.100
引用产品：CL-0481
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Constructing a prognostic risk model for Alzheimer’s disease based on ferroptosis(2023/04/27)
作者：Xiaoli Wang, Ruiqing Zhai, Zhiming Li
期刊：Frontiers in Aging Neuroscience
DOI：10.3389/fnagi.2023.1168840
影响因子 ：4.800
引用产品：CL-0481
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Cav3.2 T-Type calcium channels downregulation attenuates bone cancer pain induced by inhibiting IGF-1/HIF-1α signaling pathway in the rat spinal cord(2023/08/01)
作者：Qingying Liu, Zhongyuan Lu, Huan Ren
期刊：Journal of Bone Oncology
影响因子 ：3.400
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NQO1 regulates expression and alternative splicing of apoptotic genes associated with Alzheimers disease in PC12 cells(2023/03/31)
作者：Yingshi Du, Gejing Liu, Dong Chen
期刊：Brain and Behavior
影响因子 ：3.100
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Liquiritin Alleviates Depression-Like Behavior in CUMS Mice by Inhibiting Oxidative Stress and NLRP3 Inflammasome in Hippocampus(2022/01/11)
作者：Chang Liu, Dai Yuan, Chi Zhang
期刊：Evidence-based Complementary and Alternative Medicine
影响因子 ：2.650
引用产品：CL-0481
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LncRNA SOX2OT Knockdown Alleviates Lipopolysaccharide-Induced Damage of PC12 Cells by Regulating miR-331-3p/Neurod1 Axis(2020/12/16)
作者：Ronggang Li, Xiaofeng Li, Yong Huang
期刊：World Neurosurgery
DOI：10.1016/j.wneu.2020.12.049
影响因子 ：2.000
![LLC-WRC 256 [Walker 256] (大鼠腹水癌细胞) (种属鉴定正确）](/Public/upfile/pic/xbx/CL-0377-1.jpg)
