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产品概述
| 名称 | BV2 (小鼠小胶质细胞) (种属鉴定正确) |
| 别称 | BV-2 |
| 背景描述 | BV-2细胞是由E·Blasi建立于1990年；BV-2细胞由小鼠小神经胶质细胞经逆转录病毒介导转染v-raf/v-myc获永生化。BV-2细胞保留有小神经胶质细胞多种形态、表征和功能特征；免疫组化结果显示，BV-2细胞为MAC1、MAC2阳性；而MAC3、胶质细胞原纤维酸性蛋白、半乳糖脑苷脂为阴性。 |
| 组织来源 | 脑；胶质瘤 |
| 生长特性 | 半贴半悬 |
| 细胞形态 | 上皮细胞样 |
| 细胞类型 | 转化细胞系 |
| 生长培养基 | MEM（含NEAA）＋10% FBS＋1% P/S |
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2~3次/周 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
STR鉴定
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STR位点信息
18-3 16,17 6-7 15 5-5 17 X-1 27 1-2 19 7-1 26.2 8-1 16 1-1 16,17 19-2 13 15-3 22.3,23.3,24.3 12-1 17 6-4 18 4-2 20.3 3-2 14 2-1 16 13-1 17.1 11-2 16 17-2 15 -
STR鉴定图
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参考文献
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NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma(2020/04/15)
作者：Hui Chen, Yang Deng, Xiaoliang Gan
期刊：Molecular Neurodegeneration
DOI：10.1186/s13024-020-00372-w
影响因子 ：18.879
引用产品：CL-0493
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ROS-responsive 18β-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation(2022/04/01)
作者：Lulu Jin, Zhixin Zhu, Liangjie Hong
期刊：Bioactive Materials
DOI：10.1016/j.bioactmat.2022.03.040
影响因子 ：16.8740
引用产品：CL-0493
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Tracking autophagy process with a through bond energy transfer-based ratiometric two-photon viscosity probe(2022/06/15)
作者：Shuyang Zhai, Wei Hu, Weibo Wang
期刊：BIOSENSORS & BIOELECTRONICS
DOI：10.1016/j.bios.2022.114484
影响因子 ：12.5450
引用产品：CL-0493
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Immunomodulation of MiRNA-223-based nanoplatform for targeted therapy in retinopathy of prematurity(2022/09/12)
作者：Keke Huang, Zhiqing Lin, Yuanyuan Ge
期刊：JOURNAL OF CONTROLLED RELEASE
DOI：10.1016/j.jconrel.2022.08.006
影响因子 ：11.4670
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Olfactory bulb microglia activation mediated neuronal death in real-ambient particulate matter exposure mice with depression-like behaviors(2022/01/29)
作者：Xiaoya Ji, Rui Liu, Jiajun Guo
期刊：Science Of The Total Environment
DOI：10.1016/j.scitotenv.2022.153456
影响因子 ：10.7530
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Decellularized extracellular matrix and mesenchymal stem cells promote recovery in traumatic brain injury by synergistically enhancing neurogenesis and attenuating neuroinflammation(2022/10/01)
作者：Xuewei Zhang, Bixue Wang, Hua Hong
期刊：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
DOI：10.1016/j.jmst.2022.08.028
影响因子 ：10.3190
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Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice(2022/02/10)
作者：Libin Ni, Jian Xiao, Di Zhang
期刊：Cell Death & Disease
DOI：10.1038/s41419-022-04592-4
影响因子 ：9.685
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Erbin protects against sepsis-associated encephalopathy by attenuating microglia pyroptosis via IRE1α/Xbp1s-Ca2+ axis(2022/09/28)
作者：Guoqing Jing, Jing Zuo, Qing Fang
期刊：Journal of Neuroinflammation
DOI：10.1186/s12974-022-02598-5
影响因子 ：9.5870
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Gold nanocluster & indocyanine green based triple-effective therapy for MRSA infected central nervous system(2022/04/04)
作者：Yi Zhuo, Yi Zhang, Bing Wang
期刊：Applied Materials Today
DOI：10.1016/j.apmt.2022.101453
影响因子 ：8.6630
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Study on the antidepressant effect of panaxynol through the IκB-α/NF-κB signaling pathway to inhibit the excessive activation of BV-2 microglia(2021/03/13)
作者：Yan Zhao, Xialin Sun, Tingwen Zhang
期刊：Biomedicine & Pharmacotherapy
DOI：10.1016/j.biopha.2021.111387
影响因子 ：7.419
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Design and synthesis of 3-(4-pyridyl)-5-(4-sulfamido-phenyl)-1,2,4-oxadiazole derivatives as novel GSK-3β inhibitors and evaluation of their potential as multifunctional anti-Alzheimer agents(2020/09/28)
作者：Min Wang, Tongtong Liu, Shiming Chen
期刊：European Journal Of Medicinal Chemistry
DOI：10.1016/j.ejmech.2020.112874
影响因子 ：7.088
引用产品：CL-0493
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Neuropeptide Y in the amygdala contributes to neuropathic pain-like behaviors in rats via the neuropeptide Y receptor type 2/mitogen-activated protein kinase axis(2022/03/21)
作者：Wenhui Yan, Wuchao Liu, Junlu Wu
期刊：Bioengineered
DOI：10.1080/21655979.2022.2051783
影响因子 ：6.8320
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Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinsons disease(2019/3/4)
作者：Runxiao Lv, Lili Du, Xueyong Liu
期刊：Life Sci
影响因子 ：6.7800
引用产品：CL-0493
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The protective effect of 5-O-methylvisammioside on LPS-induced depression in mice by inhibiting the over activation of BV-2 microglia through Nf-κB/IκB-α pathway(2020/09/19)
作者：Xialin Sun, Tingwen Zhang, Yan Zhao
期刊：Phytomedicine
DOI：10.1016/j.phymed.2020.153348
影响因子 ：6.656
引用产品：CL-0493
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Aurantiamide promotes M2 polarization of microglial cells to improve the cognitive ability of mice with Alzheimers disease(2022/09/05)
作者：Heping Shen, Zhongmei He, Hongyan Pei
期刊：PHYTOTHERAPY RESEARCH
DOI：10.1002/ptr.7597
影响因子 ：6.3880
引用产品：CL-0493
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Asiatic Acid Attenuates Inflammation Induced by Salmonella via Upregulating LncRNA TVX1 in Microglia(2022/09/19)
作者：Wenshu Zou, Jingyan Zhang, Kai Zhang
期刊：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 ：6.2080
引用产品：CL-0493
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Serum Extracellular Vesicle–Derived miR-124-3p as a Diagnostic and Predictive Marker for Early-Stage Acute Ischemic Stroke(2021/07/01)
作者：Zheng Qi, Yingying Zhao, Yu Su
期刊：Frontiers in Molecular Biosciences
影响因子 ：6.113
引用产品：CL-0493
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The Regulatory NOD-Like Receptor NLRC5 Promotes Ganglion Cell Death in Ischemic Retinopathy by Inducing Microglial Pyroptosis(2021/05/20)
作者：Yang Deng, Yunzhao Fu, Longxiang Sheng
期刊：Frontiers in Cell and Developmental Biology
影响因子 ：6.081
引用产品：CL-0493
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DOK3 is involved in microglial cell activation in neuropathic pain by interacting with GPR84(2020/12/03)
作者：Wenshuang Gao, Yujuan Qu, Juan Huai
期刊：Aging-US
影响因子 ：5.9550
引用产品：CL-0493
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Rosmarinic acid attenuates inflammatory responses through inhibiting HMGB1/TLR4/NF-κB signaling pathway in a mouse model of Parkinsons disease(2019/03/14)
作者：Runxiao Lv, Lili Du, Xueyong Liu
期刊：Life Sciences
影响因子 ：5.738
引用产品：CL-0493
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High-density lipoprotein reduces microglia activation and protects against experimental autoimmune encephalomyelitis in mice(2022/01/29)
作者：Shan Hong, Min Niu, Dongmei Meng
期刊：International Immunopharmacology
DOI：10.1016/j.intimp.2022.108566
影响因子 ：5.7140
引用产品：CL-0493
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Mafenide derivatives inhibit neuroinflammation in Alzheimers disease by regulating pyroptosis(2021/10/10)
作者：Chenyang Han, Qiaohong Hu, Anqi Yu
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.295
引用产品：CL-0493
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Stress-induced phosphoprotein 1 restrains spinal cord ischaemia-reperfusion injury by modulating NF-κB signalling(2021/11/3)
作者：Hongdou Jin, Xin Ge, Zhirong Huan
期刊：Journal Of Cellular And Molecular Medicine
影响因子 ：5.2950
引用产品：CL-0493
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Activation of TREM2 attenuates neuroinflammation via PI3K/Akt signaling pathway to improve postoperative cognitive dysfunction in mice(2022/08/27)
作者：Xue Han, Xiaolei Cheng, Jiyan Xu
期刊：NEUROPHARMACOLOGY
DOI：10.1016/j.neuropharm.2022.109231
影响因子 ：5.2730
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Investigation on the mechanism of mafenide in inhibiting pyroptosis and the release of inflammatory factors(2020/04/30)
作者：Chenyang Han, Yi Yang, Anqi Yu
期刊：European Journal of Pharmaceutical Sciences
DOI：10.1016/j.ejps.2020.105303
影响因子 ：5.112
引用产品：CL-0493
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Investigation on the mechanism of mafenide in inhibiting pyroptosis and the release of inflammatory factors(2020/03/12)
作者：Chenyang Han, Yi Yang, Anqi Yu
期刊：European Journal Of Pharmaceutical Sciences
DOI：10.1016/j.ejps.2020.105303
影响因子 ：5.112
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Covalent Organic Framework (COF): A Drug and Carrier to Attenuate Retinal Ganglion Cells Death in an Acute Glaucoma Mouse Model(2022/08/10)
作者：Ke Yao, Xin Liang, Guiyang Zhang
期刊：Polymers
影响因子 ：4.9670
引用产品：CL-0493
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Isolation of Phenolic Compounds from Raspberry Based on Molecular Imprinting Techniques and Investigation of Their Anti-Alzheimer’s Disease Properties(2022/10/14)
作者：Qian Wu, Abid Naeem, Jiamei Zou
期刊：MOLECULES
影响因子 ：4.9270
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Long Noncoding RNA SNHG14 Promotes Ischemic Brain Injury via Regulating miR-199b/AQP4 Axis(2021/2/20)
作者：Guanglin Zhang, Tianxiao Li, Xiaozan Chang
期刊：Neurochemical Research
DOI：10.1007/s11064-021-03265-6.
影响因子 ：4.4140
引用产品：CL-0493
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Gelsemine Exerts Neuroprotective Effects on Neonatal Mice with Hypoxic-Ischemic Brain Injury by Suppressing Inflammation and Oxidative Stress via Nrf2/HO-1 Pathway(2022/11/30)
作者：Cheng, Shen, Chen, Chen, Wang, Liling
期刊：NEUROCHEMICAL RESEARCH
DOI：10.1007/s11064-022-03815-6
影响因子 ：4.4140
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Curcumin-Primed Umbilical Cord Mesenchymal Stem Cells-Derived Extracellular Vesicles Improve Motor Functional Recovery of Mice with Complete Spinal Cord Injury by Reducing Inflammation and Enhancing Axonal Regeneration(2022/11/30)
作者：Xiong, Wei, Tian, Haiqing, Li, Zhigang, Peng, Zhibin, Wang, Yansong
期刊：NEUROCHEMICAL RESEARCH
DOI：10.1007/s11064-022-03832-5
影响因子 ：4.4140
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Small Extracellular Vesicles of M1-BV2 Microglia Induce Neuronal PC12 Cells Apoptosis via the Competing Endogenous Mechanism of CircRNAs(2022/09/08)
作者：Sheng Gao, Luyue Bai, Shu Jia
期刊：Genes
影响因子 ：4.1410
引用产品：CL-0493
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Dihydromyricetin attenuates neuropathic pain via enhancing the transition from M1 to M2 phenotype polarization by potentially elevating ALDH2 activity in vitro and vivo(2020/9/11)
作者：Wei Zhang, Lingxiao Yang, Longyun Li
期刊：Annals of Translational Medicine
影响因子 ：3.9320
引用产品：CL-0493
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Chuanzhitongluo regulates microglia polarization and inflammatory response in acute ischemic stroke(2022/09/21)
作者：Qingqing Wang, Bin Han, Xu Man
期刊：BRAIN RESEARCH BULLETIN
DOI：10.1016/j.brainresbull.2022.09.015
影响因子 ：3.7150
引用产品：CL-0493
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SOCS-1 suppresses neuroinflammation in intracranial hemorrhage by downregulating the c-Fos/KLF4/IL-17A axis(2022/01/30)
作者：Xiaoliu Dong, Xiuqing Zhang, Shijun Xu
期刊：EUROPEAN JOURNAL OF NEUROSCIENCE
影响因子 ：3.6980
引用产品：CL-0493
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Comprehensive analysis of the differential expression profile of microRNAs in rats with spinal cord injury treated by electroacupuncture(2020/5/20)
作者：Zhidong Zhou, Hejian Li, Hongchun Li
期刊：Molecular Medicine Reports
影响因子 ：3.4230
引用产品：CL-0493
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MiR-145 enriched exosomes derived from bone marrow-derived mesenchymal stem cells protects against cerebral ischemia-reperfusion injury through downregulation of FOXO1(2022/09/27)
作者：Hai Zhou, Jing Zhou, Hongwei Teng
期刊：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
DOI：10.1016/j.bbrc.2022.09.089
影响因子 ：3.3220
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Lidocaine relieves spinal cord ischemia-reperfusion injury via long non-coding RNA MIAT-mediated Notch1 downregulation(2022/01/03)
作者：Junkai Hou, Huixin Li, Changjiang Xue
期刊：Journal of Biochemistry
影响因子 ：3.2410
引用产品：CL-0493
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Downregulation of MMP1 functions in preventing perineural invasion of pancreatic cancer through blocking the NT-3/TrkC signaling pathway(2022/09/30)
作者：Xiaoqing Xu, Xiaomin Lu, Liping Chen
期刊：JOURNAL OF CLINICAL LABORATORY ANALYSIS
影响因子 ：3.1240
引用产品：CL-0493
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Sesamin suppresses high glucose-induced microglial inflammation in the retina in vitro and in vivo(2022/01/12)
作者：Jie Zhang, Linlin Li, Fangwei Xiu
期刊：Journal of Neurophysiology
影响因子 ：2.9740
引用产品：CL-0493
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A Causal Relationship in Spinal Cord Injury Rat Model Between Microglia Activation and EGFR/MAPK Detected by Overexpression of MicroRNA-325-3p(2019/3/25)
作者：Penghui Yan, Xuejian Wu, Xiaokang Liu
期刊：J Mol Neurosci
DOI：10.1007/s12031-019-01297-w
影响因子 ：2.8660
引用产品：CL-0493
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A Causal Relationship in Spinal Cord Injury Rat Model Between Microglia Activation and EGFR/MAPK Detected by Overexpression of MicroRNA-325-3p(2019/03/25)
作者：Penghui Yan, Xuejian Wu, Xiaokang Liu
期刊：Journal of Molecular Neuroscience
DOI：10.1007/s12031-019-01297-w
影响因子 ：2.866
引用产品：CL-0493
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LncRNA H19 Regulates Lipopolysaccharide (LPS)-Induced Apoptosis and Inflammation of BV2 Microglia Cells Through Targeting miR-325-3p/NEUROD4 Axis(2020/11/17)
作者：Enyi Gu, Weikun Pan, Kangyao Chen
期刊：Journal of Molecular Neuroscience
DOI：10.1007/s12031-020-01751-0
影响因子 ：2.8660
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Ascorbic acid 6-palmitate modulates microglia M1/M2 polarization in lipopolysaccharide-stimulated BV-2 cells via PERK/elF2α mediated endoplasmic reticulum stress(2022/11/18)
作者：Li Qian, Wu Yao, Chen Xue-shen, Zeng Tao, Liu Lin-ling, Feng Zi-qi, Liu Dan-yang, Zhu Ling, Wan Li-hong
期刊：BMC Complementary Medicine and Therapies
DOI：10.1186/s12906-022-03780-1
影响因子 ：2.8380
引用产品：CL-0493
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Apelin-13 attenuates early brain injury through inhibiting inflammation and apoptosis in rats after experimental subarachnoid hemorrhage(2022/01/09)
作者：Xiaoyan Shen, Guiqiang Yuan, Bing Li
期刊：Molecular Biology Reports
DOI：10.1007/s11033-021-07028-y
影响因子 ：2.7420
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miR‐29c‐3p inhibits microglial NLRP3 inflammasome activation by targeting NFAT5 in Parkinsons disease(2020/03/30)
作者：Ruili Wang, Qing Li, Ya He
期刊：Genes To Cells
影响因子 ：2.3000
引用产品：CL-0493
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Salvianic Acid A Sodium Promotes the Recovery of Motor Function After Spinal Cord Injury in Rats by Reducing Microglia Inflammation through Regulating MIP2/Vdac1/Ndufa12 Signaling Axis(2020/10/20)
作者：Liping Li, Yuanyuan Liu, Xia Zhao
期刊：ORTHOPAEDIC SURGERY
DOI：10.1111/os.12808
影响因子 ：2.2790
引用产品：CL-0493
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Long noncoding RNA XIST knockdown relieves the injury of microglia cells after spinal cord injury by sponging miR-219-5p(2021/8/3)
作者：Xueren Zhong, Yongzheng Bao, Qiang Wu
期刊：Open Medicine
影响因子 ：2.1230
引用产品：CL-0493
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Inhibition of microRNA-19a-3p alleviates the neuropathic pain (NP) in rats after chronic constriction injury (CCI) via targeting KLF7(2022/11/02)
作者：Xiaopeng Wang, Jun Pang, Jian Cui, Aifen Liu, Hui Wang
期刊：TRANSPLANT IMMUNOLOGY
DOI：10.1016/j.trim.2022.101735
影响因子 ：2.0320
引用产品：CL-0493
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C19-Diterpenoid alkaloids from Aconitum richardsonianum(2022/08/27)
作者：Feng Xing, Jiang Xie, Yanyan Luo
期刊：Phytochemistry Letters
DOI：10.1016/j.phytol.2022.08.003
影响因子 ：1.8730
引用产品：CL-0493
