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  • Procell-TGFβR2/ TGFBR2, Human, Recombinant

TGFβR2/ TGFBR2, Human, Recombinant

货号:PCK094

价格:¥1780¥4980¥24080¥35580

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 TGF-beta Receptor type-2; TGF-beta type II Receptor; TGFBR2; Transforming Growth Factor-beta Receptor type II
物种 Human
表达宿主 Human Cells
序列信息 Thr23-Asp159
检索号 P37173
分子量 42.6 kDa
表观分子量 59 kDa
标签 C-Fc
生物活性 Measured by its ability to inhibit TGF-beta1 activity on Mv-1-lu mink lung epithelial cells. The ED50 for this effect is typically 0.2-3.0 μg/ ml in the presence of 1 ng/ mL of recombinant human TGF-beta1.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.2.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

TGFBR2 is a single-pass type I membrane Protein and contains one Protein kinase domain. TGFBR2 exsits as a heterodimeric complex with another Receptor Protein and binds TGF-beta. Signals triggered through the TGF-beta Receptor complex prompt various responses by the cell. One such response is to inhibit cell growth and division. Based on this action, the TGF-beta Receptor type 2 is sometimes called a tumor suppressor. Defects in TGFBR2 have been associated with Marfan syndrome, Loeys-Deitz aortic aneurysm syndrome, Osler-Weber-Rendu syndrome and the development of various types of tumors.
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