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  • Procell-IL-21R/ CD360, Human, Recombinant

IL-21R/ CD360, Human, Recombinant

货号:PCK182

价格:¥680¥1380¥7880¥9980

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Interleukin-21 Receptor; IL-21 Receptor; IL-21R; CD360.
物种 Human
表达宿主 Human Cells
序列信息 Cys20-Pro236
检索号 Q9HBE5-1
分子量 26.0 kDa
表观分子量 46 kDa
标签 C-6His
生物活性 Measured by its ability to bind human IL-21 in a functional ELISA. Measured by its ability to inhibit IL21-induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 1-5 ng/ ml in the presence of 10 ng/ ml of recombinant human IL23. Measured by its ability to inhibit IL21-induced Interferon gamma secretion by human natural killer lymphoma NK-92 cells. The ED50 for this effect is typically 50-200 pg/ mL in the presence of 1 ng/ ml of recombinant human IL21.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH 7.4.
复融 Please refer to it for detailed information.

背景介绍

Interleukin-21 Receptor is also known as IL-21 Receptor, IL-21R, CD360. In humans, it is encoded by the IL21R gene. It belongs to the type I Cytokine Receptor family. Type 4 subfamily contains 2 fibronectin type-III domains. Interleukin-21 Receptor is selectively expressed in lymphoid tissues and highly expressed in thymus and spleen. IL-21 is produced by CD4+ T cells in response to antigenic stimulation. Its action enhances antigen-specific responses of immune cells. The biological effects of IL-21 include induction of differentiation of T-cells-stimulated B-cells into plasma cells and memory B-cells. It also promotes the anti-tumor activity of CD8+ T-cells and NK cells.
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