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  • Procell-TNFRSF17/ BCMA/ CD269 (C-6His), Human, Recombinant

TNFRSF17/ BCMA/ CD269 (C-6His), Human, Recombinant

货号:PCK222

价格:¥980¥2080¥9680¥14080

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Tumor necrosis factor Receptor superfamily member 17; B-cell maturation Protein; CD269; TNFRSF17; BCM; BCMA
物种 Human
表达宿主 Yeast
序列信息 Met1-Ala54
检索号 Q02223
分子量 6.9 kDa
表观分子量 15-25 kDa
生物活性 Testing in progress

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

B cell maturation antigen (BCMA) is a member of the TNF Receptor superfamily. It has been designated TNFRSF17. Human BCMA is a 184 amino acid (aa) Protein consisting of a 54aa extracellular domain, a 23aa transmembrane domain, and a 107aa intracellular domain. BCMA is a type III membrane Protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF Ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development, function and regulation.
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