全国免费热线:400 650 3656

您身边的细胞培养专家!

忘记密码

个人邮箱:
验证码: captcha

账号激活

个人邮箱:
×
当前位置:首页 >> 产品中心 >> 辅助试剂 >> 细胞因子 >> Mouse

产品中心Cell Resources

联系我们CONTACT US

  • Procell-IL-33, Mouse, Recombinant

IL-33, Mouse, Recombinant

货号:PCK259

价格:¥1380¥3680¥17480¥25680

规格:
10µg
  • 10µg
  • 50µg
  • 500µg
  • 1mg
数量: - +
产品概述

产品信息

别名 Interleukin 33; IL-33; IL33; C9orf26; NKHEV; Interleukin-1 family member 11; DVS27; NF-HEV and IL- 1F11
物种 Mouse
表达宿主 E.coli
序列信息 Ser109-Ile266
检索号 Q8BVZ5
分子量 17.6 kDa
表观分子量 18 kDa
生物活性 Measured by its ability to bind Mouse IL-1 R4 in functional ELISA. Immobilized recombinant Mouse IL33 at 5 μg/ mL can bind Mouse IL1RL1with a linear range of 0.625-5ug/ ml.

产品特性

纯度 >95% as determined by reducing SDS-PAGE.
内毒素 < 1.0 EU per µg as determined by LAL test.
保存 Lyophilized Protein should be stored at < -20℃, though stable at room temperature for 3 weeks. Reconstituted Protein solution can be stored at 4-7℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
运输 The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below.
制剂 Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,pH7.4.
复融 Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in distilled water Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

背景介绍

Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory Cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family Cytokines. It is up-regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL-1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 Cytokines and acts through the Receptor IL1RL-1. BindingIL-33 to this Receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce Cytokines. In vivo, IL-33 induces the expression of IL-4, IL-5, IL-13 and also leads to severe pathological changes in mucosal organs.
朱莎莉

朱莎莉

【 湖北、河南 】

刘本佳

刘本佳

【 江苏、上海、安徽 】

章臣雄

章臣雄

【 广东、广西、贵州、云南 】

閤春喜

閤春喜

【 四川、重庆、陕西、甘肃、西藏 】

石文平

石文平

【 北京、黑龙江、吉林、辽宁 】

任施博

任施博

【 江西、福建、新疆、海南 】

李荣枫

李荣枫

【 天津、河北、内蒙古、山西 】

陈雨兰

陈雨兰

【 湖南、山东、宁夏、青海 】

田庆如

田庆如

【浙江】

黄龄

黄玲

【 华中、华西 】

李欢欢

李欢欢

【 华东、华南 】

尤会杰

尤会杰

【 华北、西南、西北 】