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产品概述
名称 | KGN (人卵巢颗粒细胞) (STR鉴定正确) |
种属 | 人 |
生长特性 | 贴壁细胞 |
细胞形态 | 成纤维细胞样 |
冻存条件 | 冻存液:55% 基础培养基+40%FBS+5%DMSO 温度:液氮 |
培养方案A(默认) |
培养条件:
气相:空气,95%;CO2,5%, 温度:37℃
|
推荐传代比例 | 1:2-1:4 |
推荐换液频率 | 2-3次/周 |
背景描述 | Granulosa cell tumor. Possible to produce progesterone after HCG addition. Cell growth is slow. |
年龄(性别) | 女性;69岁 |
组织来源 | 卵巢,腹膜 |
细胞类型 | 肿瘤细胞 |
肿瘤类型 | 卵巢癌细胞 |
生物安全等级 | BSL-1 |
倍增时间 | ~46 hours |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 10,12 D2S1338 25 D3S1358 15,17 D5S818 13 D7S820 11 D8S1179 13,14 D13S317 9 D16S539 10,12 D18S51 12,14 D19S433 13,15.2 D21S11 30,32.2 FGA 25,26 PentaD 10,13 PentaE 12,21 TH01 9 TPOX 8,9 vWA 17 D6S1043 13,20 D12S391 19,21 D2S441 10,12 -
STR鉴定图
参考文献
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Perfluorooctane sulfonate (PFOS) induces apoptosis and autophagy by inhibition of PI3K/AKT/mTOR pathway in human granulosa cell line KGN(2024/01/09)
作者:Min Gao, Haofei Shen, Qiuyuan Li
期刊:ENVIRONMENTAL POLLUTION
DOI:10.1016/j.envpol.2024.123333
影响因子 :8.900
引用产品:CL-0603
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SMAD4-induced knockdown of the antisense long noncoding RNA BRE-AS contributes to granulosa cell apoptosis(2021/05/14)
作者:Wang Yao, Xing Du, Jinbi Zhang
期刊:Molecular Therapy-Nucleic Acids
DOI:10.1016/j.omtn.2021.05.006
影响因子 :8.800
引用产品:CL-0603
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The Release of Peripheral Immune Inflammatory Cytokines Promote an Inflammatory Cascade in PCOS Patients via Altering the Follicular Microenvironment(2021/05/17)
作者:Yishan Liu, Hao Liu, Zitao Li
期刊:Frontiers in Immunology
影响因子 :7.300
引用产品:CL-0603
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Proteomic analysis reveals that cigarette smoke exposure diminishes ovarian reserve in mice by disrupting the CREB1-mediated ovarian granulosa cell proliferation-apoptosis balance(2024/01/19)
作者:Mengting Xu, Fang Li, XiaoYan Xu
期刊:ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI:10.1016/j.ecoenv.2024.115989
影响因子 :6.800
引用产品:CL-0603
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Activation of the p62-Keap1-Nrf2 pathway protects against oxidative stress and excessive autophagy in ovarian granulosa cells to attenuate DEHP-induced ovarian impairment in mice(2023/09/28)
作者:Bo Xu, Tiantian He, Hong Yang
期刊:ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI:10.1016/j.ecoenv.2023.115534
影响因子 :6.800
引用产品:CL-0603
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Single-nucleus RNA Sequencing reveals the mechanism of cigarette smoke exposure on diminished ovarian reserve in mice(2022/09/16)
作者:Fang Li, Ying Wang, Mengting Xu
期刊:ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI:10.1016/j.ecoenv.2022.114093
影响因子 :6.800
引用产品:CL-0603
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FGF2 Rescued Cisplatin-Injured Granulosa Cells through the NRF2-Autophagy Pathway(2023/09/18)
作者:Lihui Wang, Feiyan Cheng, Rumeng Pan
期刊:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
影响因子 :5.600
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Circadian Clock Genes REV-ERBs Inhibits Granulosa Cells Apoptosis by Regulating Mitochondrial Biogenesis and Autophagy in Polycystic Ovary Syndrome(2021/08/05)
作者:Lihua Sun, Hui Tian, Songguo Xue
期刊:Frontiers in Cell and Developmental Biology
影响因子 :5.500
引用产品:CL-0603
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Inhibition of cisplatin-induced Acsl4-mediated ferroptosis alleviated ovarian injury(2023/12/05)
作者:Siyuan Wang, Xuqing Li, Jun Li
期刊:CHEMICO-BIOLOGICAL INTERACTIONS
影响因子 :5.100
引用产品:CL-0603
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MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1(2021/10/21)
作者:Yan Li, Nianling Yao, Yan Gao
期刊:Bioengineered
DOI:10.1080/21655979.2021.1987125
影响因子 :4.900
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Kurarinone attenuates hydrogen peroxide-induced oxidative stress and apoptosis through activating the PI3K/Akt signaling by upregulating IGF1 expression in human ovarian granulosa cells(2022/09/17)
作者:Weiwei Li, Xiurong Yin, Yani Yan
期刊:ENVIRONMENTAL TOXICOLOGY
影响因子 :4.500
引用产品:CL-0603
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25(OH)D3 improves granulosa cell proliferation and IVF pregnancy outcomes in patients with endometriosis by increasing G2M+S phase cells(2023/12/05)
作者:Rui Hu, Leilei Li, Lanlan Liang
期刊:Reproductive Biology and Endocrinology
DOI:10.1186/s12958-023-01165-8
影响因子 :4.400
引用产品:CL-0603
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BMP4 participates in the pathogenesis of PCOS by regulating glucose metabolism and autophagy in granulosa cells under hyperandrogenic environment(2023/10/18)
作者:Ran Gu, Fangfang Dai, Chunrong Xiang
期刊:JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
DOI:10.1016/j.jsbmb.2023.106410
影响因子 :4.100
引用产品:CL-0603
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DNA Methylation Profiles of Ovarian Granular Cells from Fluorosis Female Patients Suffering Reproductive Dysfunctions(2021/10/22)
作者:Biqi He, Siyuan Dong, Qun Chen
期刊:Biological Trace Element Research
DOI:10.1007/s12011-021-02954-1
影响因子 :4.081
引用产品:CL-0603
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Roles of follicle stimulating hormone and sphingosine 1-phosphate co-administered in the process in mouse ovarian vitrification and transplantation(2023/08/24)
作者:Fei Wang, Yuan Tian, Liwen Huang
期刊:Journal of Ovarian Research
DOI:10.1186/s13048-023-01206-1
影响因子 :4.000
引用产品:CL-0603
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GIMAP7 induces oxidative stress and apoptosis of ovarian granulosa cells in polycystic ovary syndrome by inhibiting sonic hedgehog signalling pathway(2022/12/30)
作者:Anran Xu, Yuanyuan Fan, Song Liu
期刊:Journal of Ovarian Research
DOI:10.1186/s13048-022-01092-z
影响因子 :4.000
引用产品:CL-0603
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Exosomes derived from bone marrow mesenchymal stem cells attenuate NLRP3 related pyroptosis in autoimmune premature ovarian insufficiency via NF-κB pathway(2024/01/09)
作者:Jiaxin Xie, Yutao Yang, Aiping Zhuo
期刊:REPRODUCTIVE BIOMEDICINE ONLINE
DOI:10.1016/j.rbmo.2024.103814
影响因子 :4.000
引用产品:CL-0603
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miR-21-loaded BMSC-derived Exosomes repair ovarian function of autoimmune premature ovarian insufficiency by targeting MSX1(2024/01/09)
作者:Yutao Yang, Lichao Tang, Yuanling Xiao
期刊:REPRODUCTIVE BIOMEDICINE ONLINE
DOI:10.1016/j.rbmo.2024.103815
影响因子 :4.000
引用产品:CL-0603
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miR-378d is Involved in the Regulation of Apoptosis and Autophagy of and E 2 Secretion from Cultured Ovarian Granular Cells Treated by Sodium Fluoride(2021/01/06)
作者:Qun Chen, Zhen Li, Zhao Xu
期刊:BIOLOGICAL TRACE ELEMENT RESEARCH
DOI:10.1007/s12011-020-02524-x
影响因子 :3.900
引用产品:CL-0603
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Pterostilbene ameliorates oxidative damage and ferroptosis in human ovarian granulosa cells by regulating the Nrf2/HO-1 pathway(2023/03/09)
作者:Xin Chen, Qian Lin Song, Ze Hong Li
期刊:Archives Of Biochemistry And Biophysics
影响因子 :3.900
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Baicalin suppress the development of polycystic ovary syndrome via regulating the miR-874-3p/FOXO3 and miR-144/FOXO1 axis(2023/06/05)
作者:Xiaoyuan Xu, Xiaohua Xu, Xiaoshuang Wang
期刊:PHARMACEUTICAL BIOLOGY
DOI:10.1080/13880209.2023.2208636
影响因子 :3.800
引用产品:CL-0603
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PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA-induced granulosa cell apoptosis in vitro(2023/01/09)
作者:Xiaowei Ji, Yao Ye, Lin Wang
期刊:DRUG DEVELOPMENT RESEARCH
影响因子 :3.800
引用产品:CL-0603
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Whole exome sequencing reveals novel variants associated with diminished ovarian reserve in young women(2023/03/29)
作者:Na Li, Wanxue Xu, Huimin Liu
期刊:Frontiers in Genetics
DOI:10.3389/fgene.2023.1154067
影响因子 :3.700
引用产品:CL-0603
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The cytokine profiles in follicular fluid and reproductive outcomes in women with endometriosis(2022/10/26)
作者:Mutian Han, Wei Cheng, Rui Zhu
期刊:AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
影响因子 :3.600
引用产品:CL-0603
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Identification of nonfunctional PABPC1L causing oocyte maturation abnormalities and early embryonic arrest in female primary infertility(2023/09/18)
作者:Xiang Wang, Ruixi Zhou, Xiaowei Lu
期刊:CLINICAL GENETICS
影响因子 :3.500
引用产品:CL-0603
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Kisspeptin regulates the proliferation and apoptosis of ovary granulosa cells in polycystic ovary syndrome by modulating the PI3K/AKT/ERK signalling pathway(2023/01/11)
作者:Pingping Sun, Yuemin Zhang, Lilan Sun
期刊:BMC Womens Health
DOI:10.1186/s12905-022-02154-6
影响因子 :2.500
引用产品:CL-0603
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CircRNA circ_0043533 facilitates cell growth in polycystic ovary syndrome by targeting miR-1179(2022/03/25)
作者:Aixue Chen, Ruiying Jin, Weimei Zho
期刊:Reproductive Biology
DOI:10.1016/j.repbio.2022.100637
影响因子 :2.100
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KLF4 overexpression facilitates proliferation and represses apoptosis of granulosa cells in polycystic ovary syndrome(2023/06/27)
作者:Hui Miao, Congxiu Miao, Na Li
期刊:Molecular & Cellular Toxicology
DOI:10.1007/s13273-023-00354-1
影响因子 :1.700
引用产品:CL-0603
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The E3 Ubiquitin Ligase SYVN1 Plays an Antiapoptotic Role in Polycystic Ovary Syndrome by Regulating Mitochondrial Fission(2022/09/19)
作者:Lihua Sun, Hongjuan Ye, Hui Tian
期刊:Oxidative Medicine and Cellular Longevity
影响因子 :0.000
引用产品:CL-0603