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产品概述
| 名称 | SK-N-SH (人神经母细胞瘤细胞) (STR鉴定正确) |
| 别称 | SK N SH; SKN-SH; SK-NSH; SKNSH; NSH |
| 背景描述 | SK-N-SH细胞是由J·L·Bieder建系，它与SK-N-MC细胞所不同的是倍增时间较长，且多巴胺-β-羟基酶水平较高。SK-N-SH细胞在细胞介导的细胞毒性试验中用作靶细胞系。 |
| 种属 | 人 |
| 年龄（性别） | 女；4岁 |
| 组织来源 | 脑神经母细胞瘤，转移部位骨髓 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 神经母细胞瘤细胞 |
| 生物安全等级 | 1 |
| 生长培养基 | MEM（含NEAA）＋10% FBS＋1% P/S |
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2~3次/周 |
| 倍增时间 | ~44 hours |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
| 抗原表达情况 | Blood Type A; Rh+ |
| 基因表达情况 | plasminogen activator, shows increased expression of M-CSF after treatment with amyloid-beta peptide. |
| 保藏机构 | ATCC; HTB-11 ECACC; 86012802 |
STR鉴定
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STR位点信息
Amelogenin X CSF1PO 11 D2S1338 17,19 D3S1358 15,16 D5S818 12 D7S820 7,10 D8S1179 15 D13S317 11 D16S539 8,13 D18S51 13,16 D19S433 13,14 D21S11 31,31.2 FGA 23.2,24 PentaD 10,12 PentaE 7,11 TH01 7,10 TPOX 8,11 vWA 14,18 D6S1043 12,18 D12S391 18,22 D2S441 11,11.3 -
STR鉴定图
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参考文献
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Sevoflurane induced neurotoxicity in neonatal mice links to a GSK3β/Drp1-dependent mitochondrial fission and apoptosis(2022/02/02)
作者：Jinsheng Liu, Li Li, Ping Xie
期刊：Free Radical Biology And Medicine
DOI：10.1016/j.freeradbiomed.2022.01.031
影响因子 ：8.101
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Silencing of long chain noncoding RNA paternally expressed gene (PEG10) inhibits the progression of neuroblastoma by regulating microRNA-449a (miR-449a)/ribosomal protein S2 (RPS2) axis(2022/02/25)
作者：Jian Zhang, Wei Liu, Ping Ji
期刊：Bioengineered
DOI：10.1080/21655979.2022.2042999
影响因子 ：6.8320
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C-terminal truncation modulates α-Synuclein’s cytotoxicity and aggregation by promoting the interactions with membrane and chaperone(2022/08/09)
作者：Cai Zhang, Yunshan Pei, Zeting Zhang
期刊：Communications Biology
DOI：10.1038/s42003-022-03768-0
影响因子 ：6.5480
引用产品：CL-0214
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HMGB3 is Associated With an Unfavorable Prognosis of Neuroblastoma and Promotes Tumor Progression by Mediating TPX2(2021/12/20)
作者：Xiaodan Zhong, Songling Zhang
期刊：Frontiers in Cell and Developmental Biology
影响因子 ：6.0810
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CDC27-ODC1 Axis Promotes Metastasis, Accelerates Ferroptosis and Predicts Poor Prognosis in Neuroblastoma(2022/02/15)
作者：Lin Qiu, Rui Zhou, Ziyan Luo
期刊：Frontiers in Oncology
影响因子 ：5.738
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Circ_0000647 promotes cell injury by modulating miR-126-5p/TRAF3 axis in oxygen-glucose deprivation and reperfusion-induced SK-N-SH cell model(2022/01/10)
作者：Yuanqiang Dai, Ying Sheng, Yu Deng
期刊：International Immunopharmacology
DOI：10.1016/j.intimp.2021.108464
影响因子 ：5.7140
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LncRNA NEAT1 Regulates the Development of Parkinson’s Disease by Targeting AXIN1 Via Sponging miR-212-3p(2020/11/26)
作者：Tao Liu, Yang Zhang, Weihong Liu
期刊：Neurochemical Research
DOI：10.1007/s11064-020-03157-1. Epub 2020 Nov 26.
影响因子 ：4.4140
引用产品：CL-0214
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CircAXL Knockdown Alleviates Aβ1-42-Induced Neurotoxicity in Alzheimer’s Disease via Repressing PDE4A by Releasing miR-1306-5p(2022/03/01)
作者：Shengxi Meng, Bing Wang, Wentao Li
期刊：Neurochemical Research
DOI：10.1007/s11064-022-03563-7
影响因子 ：4.4140
引用产品：CL-0214
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Silencing of long non-coding RNA DLX6-AS1 weakens neuroblastoma progression by the miR‐513c‐5p/PLK4 axis(2020/10/8)
作者：Peisheng Jia, Erhu Wei, Huiqiong Liu
期刊：Iubmb Life
DOI：10.1002/iub.2392
影响因子 ：3.8850
引用产品：CL-0214
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LINC00839 Regulates Proliferation, Migration, Invasion, Apoptosis and Glycolysis in Neuroblastoma Cells Through miR-338-3p/GLUT1 Axis(2021/6/21)
作者：Lixia Yang, Liangyan Pei, Jilong Yi
期刊：Neuropsychiatric Disease and Treatment
影响因子 ：2.9890
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Long Noncoding RNA SNHG1 Knockdown Ameliorates Apoptosis, Oxidative Stress and Inflammation in Models of Parkinson’s Disease by Inhibiting the miR-125b-5p/MAPK1 Axis(2021/4/22)
作者：Xiao Xiao, Zhiwen Tan, Min Jia
期刊：Neuropsychiatric Disease and Treatment
影响因子 ：2.9890
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miR-338-3p inhibits cell growth, invasion, and EMT process in neuroblastoma through targeting MMP-2(2021/1/1)
作者：Haibin Yuan, Fengli Liu, Tongsheng Ma
期刊：Open Life Sciences
影响因子 ：1.3110
引用产品：CL-0214
