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| 名称 | PC-12(Undifferentiated) (大鼠肾上腺嗜铬细胞瘤细胞(未分化)) (种属鉴定正确) |
| 种属 | 大鼠 |
| 生长特性 | 疏松贴壁 |
| 细胞形态 | 圆形 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养方案A（默认） |
培养条件:
气相：空气，95%；CO2，5%, 温度：37℃
|
| 推荐传代比例 | 1:2-1:4 |
| 推荐换液频率 | 2-3次/周 |
| 注意事项 | 1.PC-12(Undifferentiated)细胞正常生长状态为悬浮聚团，若需要用NGF诱导时，需要使用多聚-L-赖氨酸溶液（货号 PB180523）包被培养瓶后促使细胞贴壁。2.Undifferentiated、Low differentiation和High differentiation的区别：Undifferentiated的PC-12从形态上看是圆形的，聚团生长的漂浮细胞；Low differentiation的成多角形，有较短的突起；High differentiation的细胞有多个突起，突起数目不等，突触较长，类似神经元轴突。3.Low differentiation和High differentiation是在Undifferentiated的PC-12基础上诱导产生的，Low differentiation和High differentiation指的与神经细胞表型的相似程度，High differentiation更接近神经细胞表型。 |
| 背景描述 | PC-12(Undifferentiated)细胞是来自能移植的雄性大鼠肾上腺嗜铬细胞瘤。PC-12(Undifferentiated)细胞表达神经生长因子(NGF)受体，NGF可诱导产生神经表型。PC-12(Undifferentiated)细胞不合成肾上腺素。 |
| 年龄（性别） | 雄性 |
| 组织来源 | 肾上腺嗜铬细胞瘤 |
| 细胞类型 | 肿瘤细胞 |
| 肿瘤类型 | 嗜铬细胞瘤细胞 |
种属鉴定
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种属鉴定图
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参考文献
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A value-added application of eugenol as acaricidal agent: The mechanism of action and the safety evaluation(2020/12/28)
作者：Xiaofei Shang, Lixia Dai, Chenjie Yang
期刊：Journal of Advanced Research
DOI：10.1016/j.jare.2020.12.010
影响因子 ：10.700
引用产品：CL-0412
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Low-glucose-sensitive TRPC6 dysfunction drives hypoglycemia-induced cognitive impairment in diabetes(2020/10/18)
作者：Chengkang He, Peng Gao, Yuanting Cui
期刊：Clinical and Translational Medicine
DOI：10.1002/ctm2.205
影响因子 ：10.600
引用产品：CL-0412
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Macroscopic Supramolecular Assembly Strategy to Construct 3D Biocompatible Microenvironments with Site-Selective Cell Adhesion(2021/06/11)
作者：Changyu Wang, Cuiling Lin, Rui Ming
期刊：ACS Applied Materials & Interfaces
影响因子 ：9.500
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Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice(2022/02/10)
作者：Libin Ni, Jian Xiao, Di Zhang
期刊：Cell Death & Disease
DOI：10.1038/s41419-022-04592-4
影响因子 ：9.000
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Protective effect of plastrum testudinis extract on dopaminergic neurons in a Parkinsons disease model through DNMT1 nuclear translocation and SNCAs methylation(2021/06/18)
作者：Sen Ye, Jun Zhong, Jiapei Huang
期刊：Biomedicine & Pharmacotherapy
DOI：10.1016/j.biopha.2021.111832
影响因子 ：7.500
引用产品：CL-0412
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An electrical microenvironment constructed based on electromagnetic induction stimulates neural differentiation(2023/03/13)
作者：Fangwei Qi, Ruobing Liao, Ping Wu
期刊：Materials Chemistry Frontiers
影响因子 ：7.000
引用产品：CL-0412
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Low beauvericin concentrations promote PC-12 cell survival under oxidative stress by regulating lipid metabolism and PI3K/AKT/mTOR signaling(2023/12/07)
作者：Liming Hu, Xintong Sui, Xin Dong
期刊：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
DOI：10.1016/j.ecoenv.2023.115786
影响因子 ：6.800
引用产品：CL-0412
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Neuroprotective Function of a Novel Hexapeptide QMDDQ from Shrimp via Activation of the PKA/CREB/BNDF Signaling Pathway and Its Structure–Activity Relationship(2020/06/02)
作者：Dan Wu, Shuyu Zhang, Na Sun
期刊：Journal Of Agricultural And Food Chemistry
影响因子 ：6.100
引用产品：CL-0412
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Neuroprotective effects of NDEELNK from sea cucumber ovum against scopolamine-induced PC12 cell damage through enhancing energy metabolism and upregulation of the PKA/BDNF/NGF signaling pathway(2021/06/22)
作者：Yue Zhao, Yifei Dong, Qi Ge
期刊：Food & Function
影响因子 ：6.100
引用产品：CL-0412
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Evaluation and structure–activity relationship analysis of antioxidant shrimp peptides(2019/08/16)
作者：Dan Wu, Na Sun, Jie Ding
期刊：Food & Function
影响因子 ：6.100
引用产品：CL-0412
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IL-11 ameliorates oxidative stress damage in neurons after spinal cord injury by activating the JAK/STAT signaling pathway(2023/12/30)
作者：Yang Sun, Xue Song, Zhijun Geng
期刊：INTERNATIONAL IMMUNOPHARMACOLOGY
DOI：10.1016/j.intimp.2023.111367
影响因子 ：5.600
引用产品：CL-0412
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Egg yolk phosphatidylcholine: Extraction, purification and its potential neuroprotective effect on PC12 cells(2019/03/28)
作者：Jin Chen, Songyi Lin, Na Sun
期刊：Journal of Functional Foods
影响因子 ：5.600
引用产品：CL-0412
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Optimal route of gold nanoclusters administration in mice targeting Parkinson’s disease(2020/02/21)
作者：Jinqi Hu, Guanbin Gao, Meng He
期刊：Nanomedicine
影响因子 ：5.500
引用产品：CL-0412
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A novel nonapeptide SSDAFFPFR from Antarctic krill exerts a protective effect on PC12 cells through the BCL-XL/Bax/Caspase-3/p53 signaling pathway(2021/8/31)
作者：Jingru Zheng, Mengqi Li, Chuanzhi Wang
期刊：Food Bioscience
DOI：10.1016/j.fbio.2021.101345
影响因子 ：5.200
引用产品：CL-0412
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Bioinformatics and experimental analyses of glutamate receptor and its targets genes in myocardial and cerebral ischemia(2023/06/02)
作者：Wei Liao, Chunming He, Shaochun Yang
期刊：BMC GENOMICS
DOI：10.1186/s12864-023-09408-z
影响因子 ：4.400
引用产品：CL-0412
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Adipose Mesenchymal Stem Cell-Derived Exosomes Enhance PC12 Cell Function through the Activation of the PI3K/AKT Pathway(2021/10/15)
作者：Yong Xie, Yangping Chen, Yuyuan Zhu
期刊：Stem Cells International
影响因子 ：4.300
引用产品：CL-0412
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Glutamine Improves Oxidative Stress through the Wnt3a/ β-Catenin Signaling Pathway in Alzheimers Disease In Vitro and In Vivo(2019/4/16)
作者：Yuan Wang, Qiang Wang, Jie Li
期刊：Biomed Research International
影响因子 ：3.246
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Acupuncture Ameliorates Neuronal Cell Death, Inflammation, and Ferroptosis and Downregulated miR-23a-3p After Intracerebral Hemorrhage in Rats(2021/01/05)
作者：Ying Kong, Shulin Li, Miao Zhang
期刊：Journal of Molecular Neuroscience
DOI：10.1007/s12031-020-01770-x
影响因子 ：3.100
引用产品：CL-0412
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miR‑222-3p Reduces Neuronal Cell Apoptosis and Alleviates Spinal Cord Injury by Inhibiting Bbc3 and Bim(2022/10/31)
作者：Qiangqiang Zhang, Gang Li, Jundong Kong
期刊：NEUROSCIENCE RESEARCH
DOI：10.1016/j.neures.2022.10.008
影响因子 ：2.900
引用产品：CL-0412
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Atractylenolide III induces apoptosis by regulating the Bax/Bcl-2 signaling pathway in human colorectal cancer HCT-116 Cells in vitro and in vivo(2022/01/01)
作者：Dan Zhang, Xiaofang Li, Daqiang Song
期刊：Anti-Cancer Drugs
DOI：10.1097/CAD.0000000000001136
影响因子 ：2.300
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Four new resorcinol derivatives with neuroprotective activities from Xylaria nigripes(2021/03/10)
作者：Lanqing Li, Jing Li, Hongping Long
期刊：Natural Product Research
DOI：10.1080/14786419.2021.1897591
影响因子 ：2.200
引用产品：CL-0412
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Inhibition of TERC inhibits neural apoptosis and inflammation in spinal cord injury through Akt activation and p-38 inhibition via the miR-34a-5p/XBP-1 axis(2023/01/01)
作者：Weiguo Ding, Weixing Xu, Di Lu
期刊：Open Medicine
影响因子 ：2.100
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Leonurine promotes neurite outgrowth and neurotrophic activity by modulating the GR/SGK1 signaling pathway in cultured PC12 cells(2019/2/22)
作者：Pan Meng, Qing Zhu, Hui Yang
期刊：Neuroreport
DOI：10.1097/WNR.0000000000001180
影响因子 ：1.700
引用产品：CL-0412
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microRNA-184 enhances the sensitivity of pheochromocytoma-12 cells to doxorubicin by targeting ADAM22(2021/2/4)
作者：Nairui Zhao, Na Su, Guangya Wang
期刊：Molecular & Cellular Toxicology
DOI：10.1007/s13273-021-00116-x
影响因子 ：1.700
引用产品：CL-0412
![LLC-WRC 256 [Walker 256] (大鼠腹水癌细胞) (种属鉴定正确）](/Public/upfile/pic/xbx/CL-0377-1.jpg)
