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产品概述
RPMI-1640是Moore等人于1967年在美国纽约州法罗市的罗斯韦尔公园纪念研究所（Roswell Park Memorial Institute, RPMI）开发出来的，RPMI是该研究所开发的一类细胞培养基，1640是培养基代号。RPMI-1640是改进型的McCoy 's 5A培养基，使用碳酸氢盐缓冲系统，与大多数哺乳动物细胞培养基不同的是其典型的PH8的配方。RPMI-1640培养基最初是为淋巴细胞培养专门设计的，现在已广泛应用于各种正常细胞和癌细胞的培养，尤其是悬浮细胞的培养，是使用最为广泛的培养基之一。
本产品含有多类细胞培养所需的氨基酸、维生素、无机盐等多种成分，但不含蛋白质、脂类或任何生长因子，故此产品需搭配血清或无血清添加物使用。
成分说明
形态 | 液体 |
浓度 | 1× |
规格 | 500mL |
PH | 7.2～7.4 |
L-谷氨酰胺 | 2mM |
NaHCO3 | 2000mg/L |
D-葡萄糖 | 2000mg/L |
HEPES缓冲剂 | 无 |
酚红指示剂 | 5mg/L |
储存条件 | 2℃～8℃，避光 |
运输条件 | 常温 |
有效期 | 12个月 |
注意事项
1、本产品经过滤除菌，使用时应注意无菌操作，避免污染；
2、为保持本产品的最佳使用效果，请勿进行冻融处理；
3、本产品仅用于科研或进一步研究使用，不用于诊断和治疗。
参考文献
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Sustained Antitumor Immunity Based on Persistent Luminescence Nanoparticles for Cancer Immunotherapy(2021/09/27)
作者：Ruoping Wang, Junpeng Shi, Liang Song
期刊：Advanced Functional Materials
影响因子 ：19.9240
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Circ-MBOAT2 knockdown represses tumor progression and glutamine catabolism by miR-433-3p/GOT1 axis in pancreatic cancer(2021/04/08)
作者：Zhou Xiaoxiao, Liu Kun, Cui Jing
期刊：Journal of Experimental & Clinical Cancer Research
DOI：10.1186/s13046-021-01894-x
影响因子 ：12.658
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DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation(2021/09/21)
作者：Tanjing Song, Qingli Zou, Yingying Yan
期刊：Cell Reports
DOI：10.1016/j.celrep.2021.109739
影响因子 ：9.995
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Nitric oxide-releasing micelles with intelligent targeting for enhanced anti-tumor effect of cisplatin in hypoxia(2021/08/16)
作者：Yan Chen, Lei Fang, Weixin Zhou
期刊：Journal of Nanobiotechnology
DOI：10.1186/s12951-021-00989-z
影响因子 ：9.429
引用产品：PM150110
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Isothiocyanate Iberin inhibits cell proliferation and induces cell apoptosis in the progression of ovarian cancer by mediating ROS accumulation and GPX1 expression(2021/06/17)
作者：Tingting Gong, Qian Guo, Xiao Li
期刊：Biomedicine & Pharmacotherapy
DOI：10.1016/j.biopha.2021.111533
影响因子 ：7.419
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Curcumin suppresses the malignancy of non-small cell lung cancer by modulating the circ-PRKCA/miR-384/ITGB1 pathway(2021/03/06)
作者：Xiaoqing Xu, Xinyue Zhang, Yang Zhang
期刊：Biomedicine & Pharmacotherapy
DOI：10.1016/j.biopha.2021.111439
影响因子 ：7.419
引用产品：164210 164210-50 CL-0005 CL-0016 CL-0165 CL-0166 CL-0249 CL-0299 PB180120 PM150110
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Development of an autophagy-related signature in pancreatic adenocarcinoma(2020/03/20)
作者：Peipei Yue, Chen Zhu, Yaxian Gao
期刊：Biomedicine & Pharmacotherapy
DOI：10.1016/j.biopha.2020.110080
影响因子 ：7.419
引用产品：PM150110
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H2S exposure induces cell death in the broiler thymus via the ROS-initiated JNK/MST1/FOXO1 pathway(2021/07/01)
作者：Qianru Chi, Xueyuan Hu, Zhaoyi Liu
期刊：Ecotoxicology and Environmental Safety
DOI：10.1016/j.ecoenv.2021.112488
影响因子 ：7.129
引用产品：PM150110
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TPGS-Modified Long-Circulating LiposomesLoading Ziyuglycoside I for Enhanced Therapy ofMyelosuppression(2021/09/14)
作者：Tingting Song, Hong Wang, Yue Liu
期刊：International Journal of Nanomedicine
影响因子 ：7.0330
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Transcription factor POU4F2 promotes colorectal cancer cell migration and invasion through hedgehog‐mediated epithelial‐mesenchymal transition(2021/08/10)
作者：Kaibo Guo, Peipei Wang, Leyin Zhang
期刊：Cancer Science
影响因子 ：6.7160
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FOXO3a‑SIRT6 axis suppresses aerobic glycolysis in melanoma(2020/01/17)
作者：Zhen Dong, Jie Yang, Lin Li
期刊：International Journal of Oncology
影响因子 ：5.884
引用产品：PM150110
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Circ_0027599 elevates RUNX1 expression via sponging miR-21-5p on gastric cancer progression(2021/05/25)
作者：Jinzhu Han, Zixin Yang, Shan Zhao
期刊：Eur J Clin Invest
影响因子 ：5.722
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Downregulation of microRNA-182 inhibits cell viability, invasion and angiogenesis in retinoblastoma through inhibition of the PI3K/AKT pathway and CADM2 upregulation(2018/10/9)
作者：Yanxia Huang, Xingang Nie, Guangda Li
期刊：International Journal of Oncology
影响因子 ：5.6500
引用产品：PM150110
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Downregulation of CKS1B restrains the proliferation, migration, invasion and angiogenesis of retinoblastoma cells through the MEK/ERK signaling pathway(2019/05/08)
作者：Zhou Zeng, Zhaolin Gao, Zhipei Zhang
期刊：International Journal of Molecular Medicine
影响因子 ：5.314
引用产品：PM150110
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Downregulation of CKS1B restrains the proliferation, migration, invasion and angiogenesis of retinoblastoma cells through the MEK/ERK signaling pathway(2019/5/8)
作者：Zhou Zeng, Zhaolin Gao, Zhipei Zhang
期刊：International Journal Of Molecular Medicine
影响因子 ：5.3140
引用产品：PM150110
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Long noncoding RNA MEG3 prevents vascular endothelial cell senescence by impairing miR-128-dependent Girdin downregulation(2019/05/29)
作者：Yong Lan, Yongjun Li, Dajun Li
期刊：AM J PHYSIOL-CELL PH
DOI：10.1152/ajpcell.00262.2018
影响因子 ：5.2820
引用产品：PM150110
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MicroRNA-598 inhibits the growth and maintenance of gastric cancer stem-like cells by down-regulating RRS1(2019/8/23)
作者：Yanling Ma, Fei Yan, Wujie Wei
期刊：Cell Cycle
DOI：10.1080/15384101.2019.1657338
影响因子 ：5.173
引用产品：PM150110
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Circ_0006988 promotes the proliferation, metastasis and angiogenesis of non-small cell lung cancer cells by modulating miR-491-5p/MAP3K3 axis(2021/06/30)
作者：Chao Yang, Jiang Shi, Jie Wang
期刊：Cell Cycle
DOI：10.1080/15384101.2021.1941612
影响因子 ：5.173
引用产品：164210 164210-50 CL-0165 CL-0496 CL-0519 PB180120 PM150110
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miR-937 serves as an inflammatory inhibitor in cigarette smoke extract-induced human bronchial epithelial cells by targeting IL1B and regulating TNF-α/IL-17 signaling pathway(2021/06/25)
作者：Teng Liu
期刊：Tobacco Induced Diseases
影响因子 ：5.1630
引用产品：PM150110
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Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis | Molecular and Cellular Biology(2021/9/24)
作者：Yihong Huang, Shuo Zheng, Ying Lin, Liming Kea
期刊：Molecular And Cellular Biology
影响因子 ：5.0690
引用产品：164210 CL-0041 CL-0150A CL-0152A CL-0290A CL-0525 PB180120 PM150110 PM151010
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E3 Ubiquitin Ligase HRD1 Promotes Lung Tumorigenesis by Promoting Sirtuin 2 Ubiquitination and Degradation | Molecular and Cellular Biology(2020/3/16)
作者：Liu Liu, Le Yu, Cheng Zeng
期刊：Molecular And Cellular Biology
影响因子 ：5.0690
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Systems Chemical Genetics-Based Drug Discovery: Prioritizing Agents Targeting Multiple/Reliable Disease-Associated Genes as Drug Candidates(2019/05/29)
作者：Yuanluo Quan, Hui Zhi, Qingyong Yang
期刊：Frontiers in Genetics
影响因子 ：4.772
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Silencing of long noncoding RNA SBF2-AS1 inhibits proliferation, migration and invasion and contributes to apoptosis in osteosarcoma cells by upregulating microRNA-30a to suppress FOXA1 expression(2019/8/21)
作者：Jianghua Dai, Wenzhou Huang, Chen Li
期刊： Cell Cycle
DOI：10.1080/15384101.2019.1656478
影响因子 ：4.5340
引用产品：PM150110
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LncRNA CCAT1 functions as apoptosis inhibitor in podocytes via autophagy inhibition(2019/08/29)
作者：Yanyan Su, Shuwen Yao, Shili Zhao
期刊：Journal Of Cellular Biochemistry
影响因子 ：4.480
引用产品：PM150110
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Glutamine protects against oxidative stress injury through inhibiting the activation of PI3K/Akt signaling pathway in parkinsonian cell model(2019/01/05)
作者：Yingqian Zhao, Qiang Wang, Yuan Wang
期刊：Environmental Health and Preventive Medicine
影响因子 ：4.395
引用产品：PM150110
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Up-regulation of microRNA-496 suppresses proliferation, invasion, migration and in vivo tumorigenicity of human osteosarcoma cells by targeting eIF4E(2019/4/16)
作者：Ninan Qi, Shuo Tian, Xin Li
期刊：Biochimie
DOI：10.1016/j.biochi.2019.04.017
影响因子 ：4.3720
引用产品：PM150110
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Long non‑coding RNA CASC15 facilitates esophageal squamous cell carcinoma tumorigenesis via decreasing SIM2 stability via FTO‑mediated demethylation(2020/11/30)
作者：Bo Qin, Meng Dong, Zhengyang Wang
期刊：Oncol Rep
影响因子 ：4.1360
引用产品：PM150110
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Potential efficacy and prognosis of silencing the CRLF2‑mediated AKT/mTOR pathway in pediatric acute B‑cell lymphoblastic leukemia(2018/12/7)
作者：Min Jiang, Xueqin Zou, Lingyun Lu
期刊：Oncol Rep
影响因子 ：4.1360
引用产品：PM150110
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Clinical roles of miR-136-5p and its target metadherin in thyroid carcinoma(2019/11/15)
作者：Ruizhi Gao, Qiao Que, Peng Lin
期刊：American Journal of Translational Research
DOI：PMID:31814886
影响因子 ：4.0600
引用产品：PM150110
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Synergistic effects of Rho kinase inhibitor Y-27632 and Noggin overexpression on the proliferation and neuron‐like cell differentiation of stem cells derived from human exfoliated deciduous teeth(2019/12/30)
作者：Si Yang, Cuijuan Xin, Bo Zhang
期刊：Iubmb Life
DOI：10.1002/iub.2208
影响因子 ：3.8850
引用产品：PM150110
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Linc-KIAA1737–2 promoted LPS-induced HK-2 cell apoptosis by regulating miR-27a-3p/TLR4/NF-κB axis(2021/6/2)
作者：Ming Hu, Jing Wei, Liu Yang
期刊：Journal Of Bioenergetics And Biomembranes
DOI：10.1007/s10863-021-09897-1
影响因子 ：3.8530
引用产品：PM150110
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Discovery of indolyl-containing peptides as novel antibacterial agents targeting tryptophanyl-tRNA synthetase(2020/04/21)
作者：Shuo Zhang, Xiaodan Qiu, Ran Wang
期刊：FUTURE MEDICINAL CHEMISTRY
影响因子 ：3.8080
引用产品：PM150110
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Circular RNA Circ_0006282 Promotes Cell Proliferation and Metastasis in Gastric Cancer by Regulating MicroRNA-144-5p/Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein β Axis(2021/1/27)
作者：Yunqi Hua, Hailong Wang, Haizhen Wang
期刊：Cancer Management and Research
影响因子 ：3.6020
引用产品：164210 164210-50 CL-0022 CL-0107 CL-0563 PB180120 PM150110
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Circ_0032821 Facilitates Gastric Cancer Cell Proliferation, Migration, Invasion and Glycolysis by Regulating MiR-1236-3p/HMGB1 Axis(2020/10/12)
作者：Lei Chen, Kun Chi, Huaguo Xiang
期刊：Cancer Management and Research
影响因子 ：3.6020
引用产品：164210 164210-50 CL-0022 CL-0107 CL-0169 CL-0292 CL-0563 PB180120 PM150110
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Triptolide reduces proliferation and enhances apoptosis of human non-small cell lung cancer cells through PTEN by targeting miR-21(2016/02/02)
作者：Xiaofang Li, Aimin Zang, Youchao Jia
期刊：Molecular Medicine Reports
影响因子 ：3.4230
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Runx3 expression in rectal cancer cells and its effect on cell invasion and proliferation(2019/7/23)
作者：Ye Feng, Shuohui Gao, Yongjian Gao
期刊：Oncology Letters
影响因子 ：3.1110
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A novel circular RNA, hsa-circ-0000211, promotes lung adenocarcinoma migration and invasion through sponging of hsa-miR-622 and modulating HIF1-α expression(2019/10/25)
作者：Dongjie Feng, Youtao Xu, Jingwen Hu
期刊：Biochemical And Biophysical Research Communications
DOI：10.1016/j.bbrc.2019.10.134
影响因子 ：2.9850
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Chondroitin polymerizing factor promotes breast carcinoma cell proliferation, invasion and migration and affects expression of epithelial-mesenchymal transition-related markers(2021/01/07)
作者：Yang Li, Hui Gong, Lei Feng
期刊：FEBS Open Bio
影响因子 ：2.7920
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Electroacupuncture Attenuates Immune-Inflammatory Response in Hippocampus of Rats with Vascular Dementia by Inhibiting TLR4/MyD88 Signaling Pathway(2021/12/15)
作者：Yu Bu, Wenshuang Li, Ji Lin
期刊：Chinese Journal of Integrative Medicine
影响因子 ：2.6260
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Transmembrane protein 92 performs a tumor-promoting function in breast carcinoma by contributing to the cell growth, invasion, migration and epithelial-mesenchymal transition(2020/07/23)
作者：Mingzhen Lin, Lili Teng, Xianglian Sun
期刊：Tissue & Cell
DOI：10.1016/j.tice.2020.101415
影响因子 ：2.5860
引用产品：PM150110
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Hsa-let-7c exerts an anti-tumor function by negatively regulating ANP32E in lung adenocarcinoma(2020/05/07)
作者：Lei Wang, Jun Li, Yan Li
期刊：Tissue & Cell
DOI：10.1016/j.tice.2020.101372
影响因子 ：2.5860
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Aloperine inhibits colorectal cancer cell proliferation and metastasis progress via regulating miR-296-5p/STAT3 axis(2021/12/02)
作者：Wei Han, Desong Kong, Qin Lu
期刊：Tissue & Cell
DOI：10.1016/j.tice.2021.101706
影响因子 ：2.5860
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LncRNA SOX2OT Knockdown Alleviates Lipopolysaccharide-Induced Damage of PC12 Cells by Regulating miR-331-3p/Neurod1 Axis(2020/12/16)
作者：Ronggang Li, Xiaofeng Li, Yong Huang
期刊：World Neurosurgery
DOI：10.1016/j.wneu.2020.12.049
影响因子 ：2.2100
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B3GNT3 acts as a carcinogenic factor in endometrial cancer via facilitating cell growth, invasion and migration through regulating RhoA/RAC1 pathway-associated markers(2021/03/08)
作者：Ji-Shui Wang, Fang Ruan, Lizhu Guo
期刊：Genes & Genomics
DOI：10.1007/s13258-021-01072-5
影响因子 ：2.1640
引用产品：PM150110
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Functional implications of PABPC1 in the development of ovarian cancer(2021/5/14)
作者：Cong Feng, Yanhua Han, Na Qi
期刊：Open Medicine
影响因子 ：2.1230
引用产品：PM150110
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BarH-like homeobox 1 induces the progression of cell malignant phenotype in endometrial carcinoma through the regulation of ERK/MEK signaling pathway(2021/3/27)
作者：Yuanyuan Lu, Hongyan Lu, Xin Yang
期刊：Reproductive Biology
DOI：10.1016/j.repbio.2021.100502
影响因子 ：2.0890
引用产品：PM150110
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Comparison of immunoadjuvant activities of four bursal peptides combined with H9N2 avian influenza virus vaccine(2018/11/28)
作者：Cong Zhang, Jiangfei Zhou, Zhixin Liu
期刊：Journal of Veterinary Science
影响因子 ：1.6030
引用产品：PM150110
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Teglicar Induces Apoptosis in HeLa Cervical Cancer Cells via Endoplasmic Reticulum Stress-Mediated Pathway(2020/07/23)
作者：Rui Zhang, Dunli Nie, Yan Chen
期刊：Iranian Journal of Science and Technology Transaction A-Science
DOI：10.1007/s40995-020-00940-1
影响因子 ：1.553
引用产品：PM150110
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Baicalein inhibits cell development in papillary thyroid cancer by regulating miR-206/RAP1B pathway(2020/11/16)
作者：Peng Wang, Liang Guo, Zhong Liang
期刊：Tropical Journal of Pharmaceutical Research
影响因子 ：0.5230
引用产品：PM150110
